Vanadium + Allopurinol
Allopurinol brand names: Zyloprim, Caplenal, Cosuric, Rimapurinol, Zyloric.
We found no known interaction between Vanadium and Allopurinol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Vanadium and Allopurinol
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Allopurinol and Vanadium in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Vanadium safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Allopurinol
Interactions in our licensed database are recorded against drug classes, not just single drug names. Allopurinol is filed under 5 classifications — including antigout drugs, nephrotoxic drugs, hepatotoxic drugs. Vanadium has documented interactions with 2 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate) and antidiabetes drugs (moderate) — and none of Allopurinol’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Vanadium Does Interact With Other Medications
Vanadium has 208 moderate known drug interactions in our database — Allopurinol isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Vanadium
We haven’t checked that one against Vanadium yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Vanadium. Pick one to open its full report.
Vanadium in Pregnancy & Breastfeeding
When used orally in amounts found in foods.
When used orally in medicinal amounts. Epidemiological research has found that increased urinary levels of vanadium are associated with an increased risk of both term and preterm premature rupture of membranes (PROM). When comparing tertiles of urinary vanadium levels, patients in the middle tertile had 1.66 times the risk of term PROM when compared with the lowest tertile, and those in the highest tertile had 3.75 times the risk. For preterm PROM (rupture prior to 37 weeks' gestation), those in the highest tertile had an 8.14 times increased risk when compared with those in the lowest tertile. Epidemiological research has also found that higher prenatal serum levels of vanadium are associated with impaired fetal growth, particularly in male newborns. The risk appears greatest with vanadium exposure in the second trimester.
When used orally in amounts found in foods. There is insufficient reliable information available about the safety of vanadium when used in amounts greater than those typically found in foods; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Allopurinol Is Prescribed For, and What Vanadium Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Allopurinol is a prescription medicine with approved uses on its FDA label. Vanadium is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Allopurinol is prescribed for: Allopurinol tablets (including Zyloprim) are used in adults to treat the signs and symptoms of gout — including gout attacks, tophi (uric acid deposits), joint damage, and kidney problems caused by uric acid. Allopurinol tablets are also used in adults to reduce recurrent calcium oxalate kidney stones when uric acid in the urine is too high, even after lifestyle changes. For adults and children with leukemia, lymphoma, or solid tumor cancers, allopurinol is used to control uric acid levels that rise during cancer treatment. The injectable forms — Allopurinol sodium for injection and Aloprim — are specifically for patients who cannot take medicine by mouth and are given intravenously (through a vein) in a hospital or clinical setting.
Read the rest of what Allopurinol is prescribed for
Note: allopurinol tablets are not recommended for people who have high uric acid levels but no symptoms.
Vanadium has been studied for:
-
Cancer studied, not established Vanadium has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Vanadium for cancer
Although there has been interest in using oral vanadium for cancer, there is insufficient reliable information about the clinical effects of vanadium for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Allopurinol on your own; if you are taking Vanadium for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Allopurinol
This page covers Vanadium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Allopurinol page lists 60 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).
By severity: 5 major · 45 moderate · 10 minor.
From our pharmacist’s overview on the Allopurinol page
“Allopurinol (Zyloprim) prevents gout attacks by lowering uric acid, and I would give this list real weight, because 5 of the 60 supplements and herbs on file carry a major rating. The largest cluster, 38 ingredients, is products that can stress the liver on their own, and regular beer or wine sits in that major group, since alcohol on…”
Reviewed by 2 · Jul 18, 2026
Taking Vanadium as Part of a Dietary Supplement Product? Check It for Interactions
We hold 4,701 real supplement products containing Vanadium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Vanadium. Even though Vanadium itself has no known interaction with Allopurinol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Vanadium and Allopurinol Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#51 of 1,452 supplements looked up here in the last 7 days
#481 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Vanadium reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Vanadium and Allopurinol records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Vanadium
What is Vanadium?
- Blood sugar and diabetes support
- Athletic performance and muscle building
- Lowering cholesterol
- General trace-mineral supplementation
Vanadium is a trace mineral found in tiny amounts in food, and people get plenty from a normal diet. Supplement claims for diabetes, weight, and athletic performance are not well proven, and higher doses can be toxic. Most people do not need to supplement it, and you should check with your doctor or pharmacist before using it.
Trace mineral (not a plant); supplements use vanadium salts such as vanadyl sulfate or sodium metavanadate · Capsules, tablets, often as vanadyl sulfate; sometimes in multivitamin or sports supplements
An interaction check asks whether these two react with each other — it does not ask whether Vanadium is a good idea for someone in your situation. Here is what our Vanadium record says about it on its own.
Vanadium: dosing
There is no established standard supplement dose for vanadium, and there is no recognized daily requirement for it as a separate supplement because the diet provides what the body needs. Studies in diabetes used high doses that are not considered safe for general use.If you choose to take a product, follow the directions on the label and do not exceed them.
From our Vanadium monograph — the full record covers uses, side effects and every documented interaction.
About Allopurinol
What Is Allopurinol Used For?
Brand names: Zyloprim, Caplenal, Cosuric, Rimapurinol, Zyloric
Allopurinol tablets (including Zyloprim) are used in adults to treat the signs and symptoms of gout — including gout attacks, tophi (uric acid deposits), joint damage, and kidney problems caused by uric acid. Allopurinol tablets are also used in adults to reduce recurrent calcium oxalate kidney stones when uric acid in the urine is too high, even after lifestyle changes.
For adults and children with leukemia, lymphoma, or solid tumor cancers, allopurinol is used to control uric acid levels that rise during cancer treatment. The injectable forms — Allopurinol sodium for injection and Aloprim — are specifically for patients who cannot take medicine by mouth and are given intravenously (through a vein) in a hospital or clinical setting. Note: allopurinol tablets are not recommended for people who have high uric acid levels but no symptoms.
Most-Reported Side Effects for Allopurinol
From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Vanadium
Browse every other medication we’ve checked against Vanadium — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
208 interactions
- Diclofenac Sodium ›
- Ibuprofen ›
- Aspirin ›
- Insulin (rdna) ›
- Naproxen ›
- Minocycline ›
- Glyburide ›
- Insulin (pork) ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Insulin (human) ›
- Ketoprofen ›
- Acarbose ›
- Bivalirudin ›
- Insulin Glargine ›
- Semaglutide ›
- Warfarin Sodium ›
- Bromfenac Sodium ›
- Chlorpropamide ›
- Dabigatran ›
- Diclofenac Epolamine ›
- Exenatide ›
- Glipizide ›
- Glucagon ›
- Iloprost ›
- Insulin Lispro ›
- Metformin ›
- Piroxicam ›
- Repaglinide ›
- Sitagliptin ›
- Streptokinase ›
- Ticlopidine ›
- Tirzepatide ›
- Treprostinil (oral) ›
- Abciximab ›
- Abrocitinib ›
- Acenocoumarol ›
- Acetohexamide ›
- Acetylsalicylic Acid ›
- Albiglutide ›
- Alogliptin ›
- Anacaulase-bcdb ›
- Anagrelide ›
- Anisindione ›
- Antithrombin Iii ›
- Apixaban ›
- Argatroban ›
- Betrixaban ›
- Cablivi ›
- Canagliflozin ›
- Cangrelor ›
- Cilostazol ›
- Clopidogrel ›
- Dalteparin ›
- Danaparoid ›
- Dapagliflozin ›
- Dasiglucagon Hydrochloride ›
- Defibrotide Sodium ›
- Diclofenac ›
- Dicumarol ›
Showing 60 of 208 moderate interactions — see all 208 on the Vanadium page.
No interaction 2,621 drugs checked — show the list
We also checked Vanadium against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Abemaciclib ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Methamphetamine ›
- Hydroxyurea ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Amitriptyline ›
- Methotrexate ›
- Bendamustine ›
- Acyclovir ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Pregabalin ›
- Lamotrigine ›
- Azithromycin ›
- Acetaminophen, Codeine ›
- Isotretinoin ›
- Gabapentin ›
- Dextroamphetamine ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Diazepam ›
- Candesartan Cilexetil ›
- Dapsone ›
- Cephalexin ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Cyclopentolate ›
- Mannitol ›
- Roxithromycin ›
Showing the 60 most looked-up of 2,621 medications checked with no known interaction — see the full Vanadium list.
Vanadium References
The 15 references that drive our Vanadium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Harland BF, Harden-Williams BA. Is vanadium of human nutritional importance yet? J Am Diet Assoc 1994;94:891-4. PubMed
- Sitprija V, Tungsanga K, Tosukhowong P, et al. Metabolic problems in northeastern Thailand: possible role of vanadium. Mineral Electrolyte Metab 1998;19:51-6.
- Funakoshi T, Shimada H, Kojima S, et al. Anticoagulant action of vanadate. Chem Pharmaceut Bull 1992;40:174-6. PubMed
- Halberstam M, Cohen N, Shlimovich P, et al. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes 1996;45:659-66. PubMed
- Cohen N, Halberstam M, Shlimovich P, et al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1995;95:2501-9. PubMed
- Boden G, Chen X, Ruiz J, et al. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism 1996;45:1130-5.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Goldfine AB, Simonson DC, Folli F, et al. Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. J Clin Endocrinol Metab 1995;80:3311-20. PubMed
- Cusi K, Cukier S, DeFronzo RA, et al. Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes. J Clin Endocrinol Metab 2001;86:1410-7.
- Peat F, Coomber R, Rana A, Vince A. Vanadium allergy following total knee arthroplasty. BMJ Case Rep 2018;2018. pii: bcr-2017-222092. doi: 10.1136/bcr-2017-222092. PubMed
- Jin S, Xia W, Jiang Y, et al. Urinary vanadium concentration in relation to premature rupture of membranes: A birth cohort study. Chemosphere 2018;210:1035-41. doi: 10.1016/j.chemosphere.2018.07.110. PubMed
- Garcia-Nunez I, Algaba-Marmol MA, Suarez-Vergara M, et al. Vanadium contact dermatitis: case report and studies performed. Contact Dermatitis 2019;80(2):127-8. PubMed
- Zhou Y, Zhu Q, Ma W, et al. Prenatal vanadium exposure, cytokine expression, and fetal growth: a gender-specific analysis in Shanghai MCPC study. Sci Total Environ 2019;685:1152-9. PubMed
- Jiang S, Zhou S, Liu H, et al. Concentrations of vanadium in urine with hypertension prevalence and blood pressure levels. Ecotoxicol Environ Saf 2021;213:112028. PubMed
- Zhang W, Chen H, Zeng Q, Xu S, Xia W, Li Y. Prenatal and postnatal exposure to vanadium and the immune function of children. J Trace Elem Med Biol 2021;67:126787. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Vanadium and Allopurinol Together: Common Questions
Is it safe to take Vanadium with Allopurinol?
Do Vanadium and Allopurinol have any of the same side effects?
Are Vanadium and Allopurinol used for the same thing?
How was the Vanadium and Allopurinol combination checked?
Does Vanadium interact with any other medications?
Does Allopurinol interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.