Drug & supplement interaction

Vanadium + Sevelamer

Sevelamer brand name: Renagel.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Vanadium and Sevelamer in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sevelamer states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Vanadium and Sevelamer

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sevelamer and Vanadium in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Vanadium safety at a glance

Vanadium overall Use caution Small dietary amounts are fine, but supplement doses can cause side effects and may be toxic at high levels.
Pregnancy Likely Safe When used orally in amounts found in foods. Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts found in foods. There is insufficient reliable information available about the safety of vanadium when used in amounts greater than... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sevelamer and Vanadium? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sevelamer

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sevelamer is filed under 2 classifications — including oral drugs. Vanadium has documented interactions with 2 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate) and antidiabetes drugs (moderate) — and none of Sevelamer’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Vanadium Does Interact With Other Medications

Vanadium has 208 moderate known drug interactions in our database — Sevelamer isn’t one of them. If you take anything else, check it against the full list below.

Moderate 208 No known interaction 2,622 (incl. Sevelamer)
Taking anything else?

Check Another of Your Medications Against Vanadium

Covers the 2,830 medications we’ve checked against Vanadium. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Vanadium and Sevelamer May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Vanadium

    “Allergic reactions to vanadium metal have been reported. A 68-year-old female developed an itchy, erythematous rash, ocular pruritus, and a positive skin test to vanadium after implantation of a vanadium-containing knee prosthesis. Contact dermatitis, presenting as pruritic eczema of the hand, and a positive skin patch test to vanadium was reported in a 39-year-old male who worked with vanadium-containing tools.”

    Vanadium · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 99051. Peat F, Coomber R, Rana A, Vince A. Vanadium allergy following total knee arthroplasty. BMJ Case Rep 2018;2018. pii: bcr-2017-222092. doi: 10.1136/bcr-2017-222092. PubMed
    2. 102095. Garcia-Nunez I, Algaba-Marmol MA, Suarez-Vergara M, et al. Vanadium contact dermatitis: case report and studies performed. Contact Dermatitis 2019;80(2):127-8. PubMed

    Sevelamer

    Listed in the ADVERSE REACTIONS section of the FDA label for Sevelamer. Read the label on DailyMed ›

  • Bloating or gas / Stomach upset / Diarrhea / Nausea Additional detail

    Vanadium

    “Orally, vanadium most commonly causes mild gastrointestinal upset. There is concern that taking doses exceeding the tolerable upper intake level (UL) of 1.8 mg per day can increase the risk of gastrointestinal side effects and possibly lead to more severe toxicity. At higher doses, vanadium frequently causes gastrointestinal effects including abdominal discomfort, diarrhea, nausea, and flatulence.”

    Vanadium · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 7135. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
    2. 3012. Harland BF, Harden-Williams BA. Is vanadium of human nutritional importance yet? J Am Diet Assoc 1994;94:891-4. PubMed
    3. 3055. Halberstam M, Cohen N, Shlimovich P, et al. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes 1996;45:659-66. PubMed
    4. 3056. Cohen N, Halberstam M, Shlimovich P, et al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1995;95:2501-9. PubMed
    5. 3057. Boden G, Chen X, Ruiz J, et al. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism 1996;45:1130-5.
    6. 12557. Goldfine AB, Simonson DC, Folli F, et al. Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. J Clin Endocrinol Metab 1995;80:3311-20. PubMed

    Sevelamer

    Listed in the ADVERSE REACTIONS section of the FDA label for Sevelamer. Read the label on DailyMed ›

  • Itching Additional detail

    Vanadium

    “Allergic reactions to vanadium metal have been reported. A 68-year-old female developed an itchy, erythematous rash, ocular pruritus, and a positive skin test to vanadium after implantation of a vanadium-containing knee prosthesis.”

    Vanadium · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 99051. Peat F, Coomber R, Rana A, Vince A. Vanadium allergy following total knee arthroplasty. BMJ Case Rep 2018;2018. pii: bcr-2017-222092. doi: 10.1136/bcr-2017-222092. PubMed
    2. 102095. Garcia-Nunez I, Algaba-Marmol MA, Suarez-Vergara M, et al. Vanadium contact dermatitis: case report and studies performed. Contact Dermatitis 2019;80(2):127-8. PubMed
    3. 107924. Zhang W, Chen H, Zeng Q, Xu S, Xia W, Li Y. Prenatal and postnatal exposure to vanadium and the immune function of children. J Trace Elem Med Biol 2021;67:126787. PubMed

    Sevelamer

    Listed in the ADVERSE REACTIONS section of the FDA label for Sevelamer. Read the label on DailyMed ›

  • A skin rash Additional detail

    Vanadium

    Recorded for Vanadium in the same Natural Medicines adverse-effect record shown under An allergic reaction above.

    Sevelamer

    Listed in the ADVERSE REACTIONS section of the FDA label for Sevelamer. Read the label on DailyMed ›

Reported for Vanadium but not commonly for Sevelamer: raised blood pressure, high blood sugar, kidney problems and kidney stones.

Effects for Sevelamer come from the ADVERSE REACTIONS section of its FDA label; effects for Vanadium come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Vanadium in Pregnancy & Breastfeeding

Pregnancy Likely Safe

When used orally in amounts found in foods.

Pregnancy Possibly Unsafe

When used orally in medicinal amounts. Epidemiological research has found that increased urinary levels of vanadium are associated with an increased risk of both term and preterm premature rupture of membranes (PROM). When comparing tertiles of urinary vanadium levels, patients in the middle tertile had 1.66 times the risk of term PROM when compared with the lowest tertile, and those in the highest tertile had 3.75 times the risk. For preterm PROM (rupture prior to 37 weeks' gestation), those in the highest tertile had an 8.14 times increased risk when compared with those in the lowest tertile. Epidemiological research has also found that higher prenatal serum levels of vanadium are associated with impaired fetal growth, particularly in male newborns. The risk appears greatest with vanadium exposure in the second trimester.

Lactation Likely Safe

When used orally in amounts found in foods. There is insufficient reliable information available about the safety of vanadium when used in amounts greater than those typically found in foods; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Sevelamer Products Have a Food Rule — Vanadium Should Not Break It

At least one FDA label for a product containing Sevelamer says to take it with food. If you take Vanadium on an empty stomach out of habit, keep them separate — and take Sevelamer with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sevelamer products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Starting dose of Renvela is 0.8 or 1.6 grams administered orally three times per day with meals based on serum phosphorus levels for adult patients and based on body surface area (BSA) category for pediatric patients.

From the Dosage and Administration section of the FDA label we read for Sevelamer — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Sevelamer

This page covers Vanadium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sevelamer page lists 18 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 10 minor.

From our pharmacist’s overview on the Sevelamer page

“Kidney patients who take sevelamer (Renagel) to control phosphorus have a real reason to pause over this page, and activated charcoal is why. It carries the only major rating here because it can trap medicines in the gut and sharply cut the amount the body actually gets.”

Reviewed by 2 · Jul 18, 2026

Open the Sevelamer interaction page

One more smart check

Taking Vanadium as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,701 real supplement products containing Vanadium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Vanadium. Even though Vanadium itself has no known interaction with Sevelamer, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Vanadium and Sevelamer Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Vanadium
Top 5%

#51 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sevelamer
Steady interest

#2,676 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Vanadium reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Vanadium and Sevelamer records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Vanadium

What is Vanadium?

Vanadium
  • Blood sugar and diabetes support
  • Athletic performance and muscle building
  • Lowering cholesterol
  • General trace-mineral supplementation

Vanadium is a trace mineral found in tiny amounts in food, and people get plenty from a normal diet. Supplement claims for diabetes, weight, and athletic performance are not well proven, and higher doses can be toxic. Most people do not need to supplement it, and you should check with your doctor or pharmacist before using it.

Trace mineral (not a plant); supplements use vanadium salts such as vanadyl sulfate or sodium metavanadate · Capsules, tablets, often as vanadyl sulfate; sometimes in multivitamin or sports supplements

An interaction check asks whether these two react with each other — it does not ask whether Vanadium is a good idea for someone in your situation. Here is what our Vanadium record says about it on its own.

Vanadium: dosing

There is no established standard supplement dose for vanadium, and there is no recognized daily requirement for it as a separate supplement because the diet provides what the body needs. Studies in diabetes used high doses that are not considered safe for general use.If you choose to take a product, follow the directions on the label and do not exceed them.

From our Vanadium monograph — the full record covers uses, side effects and every documented interaction.

Read the full Vanadium monograph & all interactions
Medication

About Sevelamer

What Is Sevelamer Used For?

Brand name: Renagel

Sevelamer is used to control serum phosphorus (the level of phosphorus in your blood) in people with chronic kidney disease (CKD) who are on dialysis. High phosphorus is a serious problem for dialysis patients and needs to be managed with medication and diet.

Sevelamer carbonate tablets and Renvela® (sevelamer carbonate) oral suspension are approved for adults and children 6 years of age and older. Sevelamer hydrochloride tablets are indicated for adults with CKD on dialysis; their safety and effectiveness in CKD patients not on dialysis have not been studied.

See full Sevelamer drug information
Keep checking

Other Drugs & Vanadium

Browse every other medication we’ve checked against Vanadium — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
208Moderate
0Minor
2,621No known interaction
208 Moderate 2,621 No interaction
Moderate

208 interactions

Showing 60 of 208 moderate interactions — see all 208 on the Vanadium page.

No interaction 2,621 drugs checked — show the list

We also checked Vanadium against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,621 medications checked with no known interaction — see the full Vanadium list.

See the full Vanadium interactions page
See every supplement checked against Sevelamer, ranked by severity
Evidence & sources

Vanadium References

The 15 references that drive our Vanadium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Harland BF, Harden-Williams BA. Is vanadium of human nutritional importance yet? J Am Diet Assoc 1994;94:891-4. PubMed
  2. Sitprija V, Tungsanga K, Tosukhowong P, et al. Metabolic problems in northeastern Thailand: possible role of vanadium. Mineral Electrolyte Metab 1998;19:51-6.
  3. Funakoshi T, Shimada H, Kojima S, et al. Anticoagulant action of vanadate. Chem Pharmaceut Bull 1992;40:174-6. PubMed
  4. Halberstam M, Cohen N, Shlimovich P, et al. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes 1996;45:659-66. PubMed
  5. Cohen N, Halberstam M, Shlimovich P, et al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1995;95:2501-9. PubMed
  6. Boden G, Chen X, Ruiz J, et al. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism 1996;45:1130-5.
  7. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  8. Goldfine AB, Simonson DC, Folli F, et al. Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. J Clin Endocrinol Metab 1995;80:3311-20. PubMed
  9. Cusi K, Cukier S, DeFronzo RA, et al. Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes. J Clin Endocrinol Metab 2001;86:1410-7.
  10. Peat F, Coomber R, Rana A, Vince A. Vanadium allergy following total knee arthroplasty. BMJ Case Rep 2018;2018. pii: bcr-2017-222092. doi: 10.1136/bcr-2017-222092. PubMed
  11. Jin S, Xia W, Jiang Y, et al. Urinary vanadium concentration in relation to premature rupture of membranes: A birth cohort study. Chemosphere 2018;210:1035-41. doi: 10.1016/j.chemosphere.2018.07.110. PubMed
  12. Garcia-Nunez I, Algaba-Marmol MA, Suarez-Vergara M, et al. Vanadium contact dermatitis: case report and studies performed. Contact Dermatitis 2019;80(2):127-8. PubMed
  13. Zhou Y, Zhu Q, Ma W, et al. Prenatal vanadium exposure, cytokine expression, and fetal growth: a gender-specific analysis in Shanghai MCPC study. Sci Total Environ 2019;685:1152-9. PubMed
  14. Jiang S, Zhou S, Liu H, et al. Concentrations of vanadium in urine with hypertension prevalence and blood pressure levels. Ecotoxicol Environ Saf 2021;213:112028. PubMed
  15. Zhang W, Chen H, Zeng Q, Xu S, Xia W, Li Y. Prenatal and postnatal exposure to vanadium and the immune function of children. J Trace Elem Med Biol 2021;67:126787. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Vanadium and Sevelamer Together: Common Questions

Is it safe to take Vanadium with Sevelamer?
We do not list a known interaction between Vanadium and Sevelamer. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Vanadium and Sevelamer have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Vanadium and Sevelamer at the same time of day?
At least one FDA label for a product containing Sevelamer says to take it with food. If you take Vanadium on an empty stomach out of habit, keep them separate and take Sevelamer with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Sevelamer products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Vanadium and Sevelamer combination checked?
Interactions in our licensed database are recorded against drug classes. Sevelamer is filed under 2 classifications, and Vanadium has documented interactions with 2 drug classes — none of Sevelamer's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Vanadium interact with any other medications?
Yes. Vanadium has 208 documented drug interactions in our database — Sevelamer is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sevelamer interact with any supplements?
Yes. Sevelamer has documented interactions with 18 supplements in our database — Vanadium is not one of them. The Sevelamer interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Vanadium monograph Uses, safety profile, and every drug interaction in one place Sevelamer drug information The full plain-English guide to this medication Sevelamer supplement interactions Every supplement checked against Sevelamer, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 15 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sevelamer and Vanadium?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.