Drug & supplement interaction

Sorrel + Allopurinol

Allopurinol brand names: Zyloprim, Caplenal, Cosuric, Rimapurinol, Zyloric.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Sorrel and Allopurinol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Sorrel and Allopurinol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Allopurinol and Sorrel in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sorrel safety at a glance

Sorrel overall Use caution Generally safe as a food in normal amounts, but high oxalate content can be a concern with large or concentrated doses.
Pregnancy Possibly Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of sorrel used in medicinal amounts d... Read the full pregnancy detail
Breastfeeding Possibly Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of sorrel used in medicinal amounts d... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Pharmacist analysis

Sorrel has few documented, clinically significant, drug interactions. Preliminary research in animals indicates it may interact with antiplatelet drugs and drugs that are a substrate for transporter proteins known as OATPs (Organic Anion Transporting Polypeptides).

It is unlikely sorrel has clinically significant drug interactions, and there is no known drug interaction between the drug in this monograph and sorrel. As always however, be sure to let your doctor know about all the medications you are taking so you can be appropriately monitored.

—

Still wondering about combining Allopurinol and Sorrel? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Allopurinol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Allopurinol is filed under 5 classifications — including antigout drugs, nephrotoxic drugs, hepatotoxic drugs. Sorrel has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), fexofenadine (allegra) (moderate) and organic anion-transporting polypeptide substrates (oatp) (moderate) — and none of Allopurinol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Sorrel Does Interact With Other Medications

Sorrel has 169 moderate known drug interactions in our database — Allopurinol isn’t one of them. If you take anything else, check it against the full list below.

Moderate 169 No known interaction 2,661 (incl. Allopurinol)
Taking anything else?

Check Another of Your Medications Against Sorrel

Covers the 2,830 medications we’ve checked against Sorrel. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Sorrel and Allopurinol May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on Additional detail

    Sorrel

    “Environmental exposure to sorrel pollen may trigger allergic rhinitis or bronchial asthma in hypersensitive individuals, and allergic cross-sensitivity may occur in up to 19% of people who are allergic to weed pollen.”

    Sorrel · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    1 source cited
    1. 75141. Gniazdowska, B., Doroszewska, G., and Doroszewski, W. [Hypersensitivity to weed pollen allergens in the region of Bygdoszcz]. Pneumonol.Alergol.Pol. 1993;61(7-8):367-372.

    Allopurinol

    Listed in the ADVERSE REACTIONS section of the FDA label for Allopurinol. Read the label on DailyMed ›

  • Kidney problems Worth acting on Additional detail

    Sorrel

    “Sorrel contains oxalates; irolithiasis and nephrosis may be caused by the systemic absorption of oxalates and may result in kidney damage. A case of acute tubulointerstitial nephritis (TIN) has been reported in a 12-year-old who consumed an unknown amount of wild sorrel. The patient presented with polyuria, hypophosphatemia, proteinuria, glucosuria, and hyperoxaluria.”

    Sorrel · Natural Medicines adverse-effect record, reported in hypophosphatemia.

    2 sources cited
    1. 71314. Sanz, P. and Reig, R. Clinical and pathological findings in fatal plant oxalosis. A review. Am J Forensic Med Pathol. 1992;13(4):342-345. PubMed
    2. 94019. Selçuk SN, Gülhan B, Düzova A, Teksam Ö. Acute tubulointerstitial nephritis due to large amount of sorrel (Rumex acetosa) intake. Clin Toxicol (Phila) 2015;53(5):497. PubMed

    Allopurinol

    Listed in the ADVERSE REACTIONS section of the FDA label for Allopurinol. Read the label on DailyMed ›

  • A stuffy or runny nose Additional detail

    Sorrel

    Recorded for Sorrel in the same Natural Medicines adverse-effect record shown under Wheezing above.

    Allopurinol

    Listed in the ADVERSE REACTIONS section of the FDA label for Allopurinol. Read the label on DailyMed ›

  • Nausea Additional detail

    Sorrel

    “Orally, sorrel, when used in combination with other herbs, has been reported to cause gastrointestinal side effects including nausea and an unpleasant aftertaste.”

    Sorrel · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    3 sources cited
    1. 374. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
    2. 379. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
    3. 37419. Zick, S. M., Sen, A., Feng, Y., Green, J., Olatunde, S., and Boon, H. Trial of Essiac to ascertain its effect in women with breast cancer (TEA-BC). J Altern Complement Med 2006;12(10):971-980. PubMed

    Allopurinol

    Listed in the ADVERSE REACTIONS section of the FDA label for Allopurinol. Read the label on DailyMed ›

Reported for Sorrel but not commonly for Allopurinol: passing urine more often.

Effects for Allopurinol come from the ADVERSE REACTIONS section of its FDA label; effects for Sorrel come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Sorrel in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of sorrel used in medicinal amounts during pregnancy and lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Sorrel or Allopurinol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Sorrel or Allopurinol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Allopurinol

This page covers Sorrel only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Allopurinol page lists 60 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 45 moderate · 10 minor.

From our pharmacist’s overview on the Allopurinol page

“Allopurinol (Zyloprim) prevents gout attacks by lowering uric acid, and I would give this list real weight, because 5 of the 60 supplements and herbs on file carry a major rating. The largest cluster, 38 ingredients, is products that can stress the liver on their own, and regular beer or wine sits in that major group, since alcohol on…”

Reviewed by 2 · Jul 18, 2026

Open the Allopurinol interaction page

One more smart check

Taking Sorrel as Part of a Dietary Supplement Product? Check It for Interactions

We hold 224 real supplement products containing Sorrel, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sorrel. Even though Sorrel itself has no known interaction with Allopurinol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sorrel and Allopurinol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sorrel
Top 25%

#337 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Allopurinol
Top 25%

#415 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sorrel reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Sorrel and Allopurinol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sorrel

What is Sorrel?

Sorrel
  • Sinus and respiratory congestion
  • Digestive upset
  • Fever
  • Skin conditions and inflammation
  • Antioxidant support

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for any health benefit is limited, and its high oxalate content means it should be used in moderation, especially by people prone to kidney stones.

Rumex acetosa · Polygonaceae · Leaves (and sometimes whole aerial parts) · Fresh leaves in cooking, tea, dried herb, tincture, and as an ingredient in some herbal combination products

An interaction check asks whether these two react with each other — it does not ask whether Sorrel is a good idea for someone in your situation. Here is what our Sorrel record says about it on its own.

Sorrel: dosing

There is no well-established standardized medicinal dose for sorrel. As a food, it is used in normal culinary amounts.When sorrel appears in herbal supplement products, the amount varies by brand. Follow the directions on the product label and do not exceed the recommended dose. Because of the oxalate concern, it is wise to avoid taking large amounts over long periods.

From our Sorrel monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sorrel monograph & all interactions
Medication

About Allopurinol

What Is Allopurinol Used For?

Brand names: Zyloprim, Caplenal, Cosuric, Rimapurinol, Zyloric

Allopurinol tablets (including Zyloprim) are used in adults to treat the signs and symptoms of gout — including gout attacks, tophi (uric acid deposits), joint damage, and kidney problems caused by uric acid. Allopurinol tablets are also used in adults to reduce recurrent calcium oxalate kidney stones when uric acid in the urine is too high, even after lifestyle changes.

For adults and children with leukemia, lymphoma, or solid tumor cancers, allopurinol is used to control uric acid levels that rise during cancer treatment. The injectable forms — Allopurinol sodium for injection and Aloprim — are specifically for patients who cannot take medicine by mouth and are given intravenously (through a vein) in a hospital or clinical setting. Note: allopurinol tablets are not recommended for people who have high uric acid levels but no symptoms.

Most-Reported Side Effects for Allopurinol

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 8,726 reports
Fatigue 8,284 reports
Dyspnea 7,956 reports
Nausea 7,333 reports
Acute kidney injury 6,761 reports
See full Allopurinol drug information
Keep checking

Other Drugs & Sorrel

Browse every other medication we’ve checked against Sorrel — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
169Moderate
0Minor
2,660No known interaction
169 Moderate 2,660 No interaction
Moderate

169 interactions

Showing 60 of 169 moderate interactions — see all 169 on the Sorrel page.

No interaction 2,660 drugs checked — show the list

We also checked Sorrel against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,660 medications checked with no known interaction — see the full Sorrel list.

See the full Sorrel interactions page
See every supplement checked against Allopurinol, ranked by severity
Evidence & sources

Sorrel References

The 8 references that drive our Sorrel monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Zick, S. M., Sen, A., Feng, Y., Green, J., Olatunde, S., and Boon, H. Trial of Essiac to ascertain its effect in women with breast cancer (TEA-BC). J Altern Complement Med 2006;12(10):971-980. PubMed
  4. Sanz, P. and Reig, R. Clinical and pathological findings in fatal plant oxalosis. A review. Am J Forensic Med Pathol. 1992;13(4):342-345. PubMed
  5. Gniazdowska, B., Doroszewska, G., and Doroszewski, W. [Hypersensitivity to weed pollen allergens in the region of Bygdoszcz]. Pneumonol.Alergol.Pol. 1993;61(7-8):367-372.
  6. Selçuk SN, Gülhan B, Düzova A, Teksam Ö. Acute tubulointerstitial nephritis due to large amount of sorrel (Rumex acetosa) intake. Clin Toxicol (Phila) 2015;53(5):497. PubMed
  7. Ahn JH, Kim J, Rehman NU, Kim HJ, Ahn MJ, Chung HJ. Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine. Pharmaceutics. 2020;12(6):E547. PubMed
  8. Jeong D, Irfan M, Lee DH, Hong SB, Oh JW, Rhee MH. Rumex acetosa modulates platelet function and inhibits thrombus formation in rats. BMC Complement Med Ther. 2020;20(1):98. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sorrel and Allopurinol Together: Common Questions

Is it safe to take Sorrel with Allopurinol?
We do not list a known interaction between Sorrel and Allopurinol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Sorrel and Allopurinol have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Sorrel and Allopurinol combination checked?
Interactions in our licensed database are recorded against drug classes. Allopurinol is filed under 5 classifications, and Sorrel has documented interactions with 3 drug classes — none of Allopurinol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Sorrel interact with any other medications?
Yes. Sorrel has 169 documented drug interactions in our database — Allopurinol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Allopurinol interact with any supplements?
Yes. Allopurinol has documented interactions with 60 supplements in our database — Sorrel is not one of them. The Allopurinol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sorrel monograph Uses, safety profile, and every drug interaction in one place Allopurinol drug information The full plain-English guide to this medication Allopurinol supplement interactions Every supplement checked against Allopurinol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Allopurinol and Sorrel?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.