Herb & supplement monograph

Macrobiotic Diet Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Macrobiotic Diet

0 medications have a known interaction with Macrobiotic Diet, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Macrobiotic Diet. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Macrobiotic Diet combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Macrobiotic Diet: Uses, Safety & Side Effects

The bottom line

The macrobiotic diet is a plant-based eating pattern centered on whole grains, vegetables, and beans, with limited animal products and processed foods. Some versions can be healthy, but strict versions risk nutrient shortfalls, and there is no strong proof it treats or cures diseases like cancer. Talk to your doctor or a dietitian before starting, especially if you have a health condition.

Common forms
Whole-food eating plan based on whole grains, vegetables, and legumes
People commonly use it for
  • General wellness and longevity
  • Cancer prevention and support (popular belief)
  • Heart health
  • Weight management
  • Digestive health

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Balanced versions can be healthy, but strict versions may cause nutrient deficiencies.

PregnancyUse caution

Strict versions may not provide enough protein, calories, or key nutrients; medical supervision is advised.

BreastfeedingUse caution

Nursing parents need adequate calories and nutrients, so strict versions should be supervised by a clinician.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

The macrobiotic diet is an eating pattern, not a single herb or supplement. It grew out of ideas about balance and food, and it became popular in Japan and later in Western countries. The diet focuses on whole, natural, and locally grown foods.

A typical macrobiotic plan is built mostly around whole grains (like brown rice), along with vegetables, beans, sea vegetables (seaweed), and fermented soy foods such as miso. It limits or avoids meat, dairy, eggs, refined sugar, and heavily processed foods. Some people include small amounts of fish, while stricter followers eat almost only grains.

People often choose this diet for general health, to eat more plant foods, or in the hope of preventing or fighting disease. The diet also comes with a philosophy about lifestyle and the balance of foods, sometimes described using the ideas of yin and yang.

How it works

Any benefits likely come from general healthy-eating principles rather than a single magic ingredient. A diet high in fiber, vegetables, and plant proteins, and low in red meat, added sugar, and processed food, may support a healthy weight, steady blood sugar, and better cholesterol levels.

The diet also provides plant compounds like antioxidants and phytochemicals found in vegetables, beans, and whole grains. These have been studied in lab and population research for general health, but eating them as part of this specific diet has not been proven to prevent or treat disease.

The traditional yin-yang balancing ideas behind the diet are based on philosophy, not on modern nutritional science.

Effectiveness

Does Macrobiotic Diet work?

Evidence overview · 8 uses evaluated
8 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Macrobiotic Diet, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 8 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Biliary disorders
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using the macrobiotic diet for gallstones, there is insufficient reliable information about the clinical effects of the macrobiotic diet for this purpose.

Insufficient Reliable Evidence To Rate Cancer
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using the macrobiotic diet for various cancers, including colon cancer, there is insufficient reliable information about the clinical effects of the macrobiotic diet for these conditions.

Insufficient Reliable Evidence To Rate Cardiovascular disease (CVD)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using the macrobiotic diet for CVD, including coronary heart disease, hyperlipidemia, and hypertension, there is insufficient reliable information about the clinical effects of the macrobiotic diet for these conditions.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

It is unclear if the macrobiotic diet is beneficial in patients with diabetes.

Insufficient Reliable Evidence To Rate Endometriosis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using the macrobiotic diet for endometriosis, there is insufficient reliable information about the clinical effects of the macrobiotic diet for this purpose.

Insufficient Reliable Evidence To Rate Hyperlipidemia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if the macrobiotic diet is beneficial in patients with hyperlipidemia.

Insufficient Reliable Evidence To Rate Menopausal symptoms
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using the macrobiotic diet for menopausal symptoms, there is insufficient reliable information about the clinical effects of the macrobiotic diet for this purpose.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using the macrobiotic diet for obesity, including metabolic disorders, there is insufficient reliable information about the clinical effects of the macrobiotic diet for these conditions.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

A balanced, less strict macrobiotic diet with a variety of grains, vegetables, beans, and some fish can be reasonably healthy for many adults. The main concern is with strict versions that cut out most food groups.

Strict macrobiotic diets may not supply enough protein, calories, vitamin B12, vitamin D, calcium, iron, and zinc. Over time this can lead to deficiencies, weakness, anemia, or bone problems. People at higher risk include children, older adults, and anyone with a serious illness who needs strong nutrition.

For pregnancy and breastfeeding, use caution. The body needs extra calories and nutrients during these times, and strict versions of the diet may fall short. If you are pregnant or nursing and want to follow this diet, work closely with your doctor and a registered dietitian. Anyone with cancer or another serious medical condition should not use this diet in place of recommended medical care.

Side effects

The diet itself does not usually cause immediate side effects. Problems are more likely from not getting enough nutrients over time, especially on strict versions.

These problems can include weight loss, fatigue, weakness, anemia, and weakened bones. In growing children, poor nutrition from a very strict diet can affect growth and development. A high-fiber diet may also cause bloating or gas at first.

If you feel unusually tired, lose weight without trying, or feel weak, see your healthcare provider and consider a check of your nutrient levels.

Macrobiotic Diet: Reported Adverse Effects

Documented safety reports on Macrobiotic Diet from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

The macrobiotic diet is generally well tolerated when used with adequate supplementation or dietary modifications to ensure that nutritional needs are met.

Most Common Adverse Effects:

Increased risk of rickets, osteoporosis, and deficiencies in calcium, iron, vitamin B2, vitamin B12, and vitamin D. In children, following a strict macrobiotic diet has been associated with reduced height for age and worsened cognitive function, likely due to the associated nutrient deficiencies.

Reports by condition
Bone loss Musculoskeletal

The macrobiotic diet has been associated with increased risk of rickets and osteoporosis, likely due to calcium and vitamin D deficiency. Following a strict macrobiotic diet that does not include additional intake of fish and fat has also been associated with reduced height for age in children less than 8-years-old.

  1. Dagnelie PC, Van Dusseldorp M, Van Staveren WA, Hautvast JG. Effects of macrobiotic diets on linear growth in infants and children until 10 years of age. Eur J Clin Nutr 1994;48 Suppl 1:S103-S111.
Cognitive function Neurologic/CNS

Following a strict macrobiotic diet has been associated with worsened cognitive function in children. Epidemiological research found that consuming a strict macrobiotic diet is associated with lower psychological and intelligence test scores compared to an omnivorous (normal) diet in children. Increased occurrence of vitamin B12 deficiency in children following the macrobiotic diet might be the reason for the worsened cognitive function. However, other epidemiologic evidence did not find that following a macrobiotic diet delays cognitive development in children. The discrepancy in results might be due to the nutritional variation within the different macrobiotic diets.

  1. Louwman MW, Van Dusseldorp M, van de Vijver FJ, et al. Signs of impaired cognitive function in adolescents with marginal cobalamin status. Am J Clin Nutr 2000;72(3):762-9.
  2. Van Staveren WA, Dagnelie PC. Food consumption, growth, and development of Dutch children fed on alternative diets. Am J Clin Nutr 1988;48(3 Suppl):819-21.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no standard dose for a diet. Instead, macrobiotic eating is about food choices and proportions, often with grains making up a large share of meals and vegetables and beans filling the rest.

If you want to try this way of eating, choose a balanced version, include a variety of foods, and avoid the most restrictive forms. Many people on plant-based diets need a vitamin B12 supplement, and possibly vitamin D, calcium, iron, or omega-3s. A registered dietitian can help you plan meals and decide which supplements you may need.

References & further reading

The 3 references that drive our Macrobiotic Diet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Van Staveren WA, Dagnelie PC. Food consumption, growth, and development of Dutch children fed on alternative diets. Am J Clin Nutr 1988;48(3 Suppl):819-21. PubMed
  2. Louwman MW, Van Dusseldorp M, van de Vijver FJ, et al. Signs of impaired cognitive function in adolescents with marginal cobalamin status. Am J Clin Nutr 2000;72(3):762-9. PubMed
  3. Dagnelie PC, Van Dusseldorp M, Van Staveren WA, Hautvast JG. Effects of macrobiotic diets on linear growth in infants and children until 10 years of age. Eur J Clin Nutr 1994;48 Suppl 1:S103-S111.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Macrobiotic Diet: Common Questions

What is Macrobiotic Diet used for, and does it work?
People use Macrobiotic Diet for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Macrobiotic Diet interact with prescription medications?
We do not currently list any known drug interactions for Macrobiotic Diet. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Macrobiotic Diet interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Macrobiotic Diet with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Macrobiotic Diet interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is the Macrobiotic Diet?
It is a mostly plant-based eating pattern built around whole grains, vegetables, beans, and sometimes fish, while limiting meat, dairy, sugar, and processed foods.
Can the Macrobiotic Diet cure cancer?
No. There is no reliable scientific evidence that it cures or treats cancer, and it should never replace treatment recommended by your cancer care team.
Is the Macrobiotic Diet safe?
A balanced version can be healthy for many adults, but strict versions can lead to nutrient shortfalls and are riskier for children, older adults, pregnant people, and those who are ill.
Do I need supplements on a Macrobiotic Diet?
Often yes. Many people on this diet need vitamin B12, and possibly vitamin D, calcium, iron, or omega-3s, so it is wise to check with a dietitian or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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