Drug & supplement interaction

Sorrel + Diclofenac epolamine

Diclofenac epolamine brand names: Flector, Licart.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Sorrel has a moderate interaction with Diclofenac epolamine. Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Sorrel and Diclofenac epolamine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Diclofenac epolamine

Diclofenac epolamine falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Sorrel interacts with.

Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
In vitro, sorrel has been shown to inhibit platelet aggregation. However, this effect has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the situation with Flector or Licart (diclofenac epolamine). This is a topical NSAID patch you stick on a sore spot. Like other NSAIDs, diclofenac can make platelets a little less sticky, which slightly raises bleeding risk. The worry is that sorrel might do the same thing, so stacking them could, in theory, add up and lead to easier bruising or bleeding.

That said, I want to keep this in perspective. The platelet effect of sorrel has only shown up in test-tube studies, not in real people, so the evidence here is weak. Using sorrel as a food is very unlikely to matter. If you take concentrated sorrel supplements, or you notice unusual bruising or bleeding, just check in with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Jeong D, Irfan M, Lee DH, Hong SB, Oh JW, Rhee MH. Rumex acetosa modulates platelet function and inhibits thrombus formation in rats. BMC Complement Med Ther. 2020;20(1):98. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Sorrel Also Interacts With Other Medications

Sorrel has 168 moderate known drug interactions in our database — the Diclofenac epolamine one above is one of them. If you take anything else, check it against the full list below.

Moderate 168 No known interaction 2,662 (incl. Diclofenac epolamine)
Taking anything else?

Check Another of Your Medications Against Sorrel

Covers the 2,830 medications we’ve checked against Sorrel. Pick one to open its full report.

From our Q&A

Questions About Sorrel or Diclofenac epolamine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Sorrel or Diclofenac epolamine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Diclofenac epolamine

This page covers Sorrel only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diclofenac epolamine page lists 292 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Asarabacca (major), Beer (major), Danshen (major), Piracetam (major) and Siberian Cocklebur (major).

By severity: 6 major · 259 moderate · 27 minor.

From our pharmacist’s overview on the Diclofenac epolamine page

“Even as a patch, diclofenac epolamine (Flector, Licart) is still an NSAID that reaches the bloodstream, and its 292 supplement interactions call for genuine care, six of them rated major. The bulk of the list, 202 ingredients, thins the blood or slows clotting, which stacks onto an NSAID's built-in bleeding risk.”

Reviewed by 2 · Jul 18, 2026

Open the Diclofenac epolamine interaction page

One more smart check

Taking Sorrel as Part of a Dietary Supplement Product? Check It for Interactions

We hold 224 real supplement products containing Sorrel, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sorrel. Your product may carry other ingredients that interact with Diclofenac epolamine too, on top of Sorrel — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sorrel and Diclofenac epolamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sorrel
Top 25%

#356 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diclofenac epolamine
Top half

#1,334 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Sorrel

What is Sorrel?

Sorrel
  • Sinus and respiratory congestion
  • Digestive upset
  • Fever
  • Skin conditions and inflammation
  • Antioxidant support

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for any health benefit is limited, and its high oxalate content means it should be used in moderation, especially by people prone to kidney stones.

Read the full Sorrel monograph & all interactions
Keep checking

Other Drugs & Sorrel

Browse every other medication we’ve checked against Sorrel — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
168Moderate
0Minor
2,661No known interaction
168 Moderate 2,661 No interaction
Moderate

168 interactions

Showing 60 of 168 moderate interactions — see all 168 on the Sorrel page.

No interaction 2,661 drugs checked — show the list

We also checked Sorrel against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,661 medications checked with no known interaction — see the full Sorrel list.

See the full Sorrel interactions page
See every supplement checked against Diclofenac epolamine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Sorrel monograph › Uses, safety, and every drug interaction in one place Diclofenac epolamine supplement interactions › Every supplement checked against Diclofenac epolamine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Sorrel and Diclofenac epolamine Together: Common Questions

Can you take Sorrel with Diclofenac epolamine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Sorrel and Diclofenac epolamine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Diclofenac epolamine and Sorrel?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.