Drug & supplement interaction

Tyramine + Sorafenib

Sorafenib brand name: Nexavar.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Tyramine and Sorafenib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sorafenib states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Tyramine and Sorafenib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sorafenib and Tyramine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tyramine safety at a glance

Tyramine overall Use caution Tyramine in normal foods is fine for most people, but it can be harmful for those who are sensitive or taking certain drugs.
Pregnancy Use caution Tyramine from ordinary food is generally fine, but concentrated supplemental use is not recommended and not well studied.
Breastfeeding Use caution Tyramine from a normal diet is generally fine, but deliberately taking it in supplement form is not advised due to a lack of safety data.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sorafenib and Tyramine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sorafenib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sorafenib is filed under 4 classifications — including anticoagulant/antiplatelet drugs, glucuronidated drugs, cytochrome p450 3a4 (cyp3a4) substrates. Tyramine has documented interactions with 4 drug classes — the most serious being antihypertensive drugs (major), monoamine oxidase inhibitors (maois) (major) and alcohol (moderate) — and none of Sorafenib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Tyramine Does Interact With Other Medications

Tyramine has 181 major, 1 moderate, 171 minor known drug interactions in our database — Sorafenib isn’t one of them. If you take anything else, check it against the full list below.

Major 181 Moderate 1 Minor 171 No known interaction 2,477 (incl. Sorafenib)
Taking anything else?

Check Another of Your Medications Against Tyramine

Covers the 2,830 medications we’ve checked against Tyramine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Tyramine and Sorafenib May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    Tyramine

    “Orally and intravenously, unspecified doses of tyramine have increased systolic, but not diastolic, blood pressure. Intravenous tyramine is not used clinically but is commonly used to examine safety and interaction outcomes. A single dose of oral tyramine 400 mg has been reported to cause heart palpitations and elevations in systolic blood pressure in healthy volunteers.”

    Tyramine · Natural Medicines adverse-effect record, reported in angina.

    6 sources cited
    1. 100189. VanDenBerg CM, Blob LF, Kemper EM, Azzaro AJ. Tyramine pharmacokinetics and reduced bioavailability with food. J Clin Pharmacol. 2003;43(6):604-9. DOI
    2. 100190. Meck JV, Martin DS, D'Aunno DS, Waters WW. Pressor response to intravenous tyramine is a marker of cardiac, but not vascular, adrenergic function. J Cardiovasc Pharmacol. 2003;41(1):126-31. PubMed
    3. 101013. Colombo F, Porro T, del Rosso G, Bertalero P, Orlandi L, Libretti A. Cardiovascular responses to physical exercise and tyramine infusion in hypertensive and normotensive subjects. J Hum Hypertens. 1989;3(4):245-9.
    4. 101014. Pace DG, Reele SB, Rozik LM, Rogers-Phillips CA, Dabice JA, Givens SV. Evaluation of methods of administering tyramine to raise systolic blood pressure. Clin Pharmacol Ther. 1988;44(2):137-44. PubMed
    5. 105519. Rafehi M, Faltraco F, Matthaei J, et al. Highly variable pharmacokinetics of tyramine in humans and polymorphisms in OCT1, CYP2D6, and MAO-A. Front Pharmacol. 2019 Oct 30;10:1297. PubMed
    6. 101018. Caston JC, Eaton CL, Gheorghiu BP, Ware LL. Tyramine induced hypertensive episodes and panic attacks in hereditary deficient monoamine oxidase patients: case reports. J S C Med Assoc. 2002;98(4):187-92.

    Sorafenib

    Listed in the ADVERSE REACTIONS section of the FDA label for Sorafenib. Read the label on DailyMed ›

Reported for Tyramine but not commonly for Sorafenib: a heart attack, a fast or pounding heartbeat, blurred vision and anxiety or restlessness.

Effects for Sorafenib come from the ADVERSE REACTIONS section of its FDA label; effects for Tyramine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 20,576 voluntary FDA FAERS reports for Sorafenib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Sorafenib Products Have a Food Rule — Tyramine Should Not Break It

At least one FDA label for a product containing Sorafenib says to take it on an empty stomach. Most supplements — Tyramine included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Sorafenib on its own and move Tyramine to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sorafenib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION The recommended dosage is 400 mg orally twice daily without food.

From the Dosage and Administration section of the FDA label we read for Sorafenib — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Tyramine or Sorafenib

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Tyramine or Sorafenib, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Sorafenib

This page covers Tyramine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sorafenib page lists 285 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Grapefruit (major), Piracetam (major) and St. John's Wort (major).

By severity: 5 major · 241 moderate · 39 minor.

From our pharmacist’s overview on the Sorafenib page

“If you're on sorafenib (Nexavar) for cancer, be genuinely careful here, and learn the five major-rated entries first. Most of the 285 ingredients listed either have blood-thinning effects that stack onto sorafenib's bleeding risk (more than 200 do) or affect CYP3A4, the liver enzyme that clears the drug, pushing its level too high or t…”

Reviewed by 2 · Jul 18, 2026

Open the Sorafenib interaction page

One more smart check

Taking Tyramine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 20 real supplement products containing Tyramine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tyramine. Even though Tyramine itself has no known interaction with Sorafenib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Tyramine and Sorafenib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tyramine
Top half

#577 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sorafenib
Steady interest

#2,003 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tyramine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Tyramine and Sorafenib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tyramine

What is Tyramine?

  • Studied for effects on blood pressure
  • Discussed in relation to migraine and headache triggers
  • Of interest in food and diet science
  • Subject of research on the nervous system

Tyramine is a natural compound formed when certain proteins break down, and it is found in aged cheeses, cured meats, fermented foods, and some other items. It is not a typical health supplement and is best known for the problems it can cause—such as dangerous spikes in blood pressure—in people taking certain medications or in those who are sensitive to it. If you have been told to follow a low-tyramine diet, talk with your pharmacist or doctor before making changes.

Not a plant part; tyramine is a naturally occurring compound found in many foods · Naturally present in aged and fermented foods; not commonly sold as a stand-alone supplement

An interaction check asks whether these two react with each other — it does not ask whether Tyramine is a good idea for someone in your situation. Here is what our Tyramine record says about it on its own.

Tyramine: dosing

There is no recommended supplement dose for tyramine, because it is not meant to be taken as a health product. Instead, the main guidance is about how much tyramine to allow in the diet for people who are sensitive to it.If you have been placed on a low-tyramine diet, the goal is usually to limit aged, fermented, cured, or spoiled foods rather than to count exact milligrams. Your pharmacist or doctor can give you a food list suited to your situation.Do not try to take tyramine on purpose.

From our Tyramine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tyramine monograph & all interactions
Medication

About Sorafenib

What Is Sorafenib Used For?

Brand name: Nexavar

Sorafenib tablets are approved to treat three types of cancer. The first is unresectable hepatocellular carcinoma (HCC) — liver cancer that cannot be removed with surgery. The second is advanced renal cell carcinoma (RCC) — kidney cancer that has spread or progressed. Both the brand Nexavar and generic sorafenib tablets are approved for these two uses.

The third use is for locally recurrent or metastatic, progressive differentiated thyroid carcinoma (DTC) — thyroid cancer that has spread or worsened and no longer responds to radioactive iodine treatment. Nexavar and sorafenib tablets are both approved for this use as well.

See full Sorafenib drug information
Keep checking

Other Drugs & Tyramine

Browse every other medication we’ve checked against Tyramine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

181Major
1Moderate
171Minor
2,476No known interaction
181 Major 1 Moderate 171 Minor 2,476 No interaction
Major

181 interactions

Showing 60 of 181 major interactions — see all 181 on the Tyramine page.

Moderate

1 interaction

Minor

171 interactions

Showing 60 of 171 minor interactions — see all 171 on the Tyramine page.

No interaction 2,476 drugs checked — show the list

We also checked Tyramine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,476 medications checked with no known interaction — see the full Tyramine list.

See the full Tyramine interactions page
See every supplement checked against Sorafenib, ranked by severity
Evidence & sources

Tyramine References

The 15 references that drive our Tyramine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pawar RS, Grundel E. Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs). Drug Test Anal 2017;9:500-517. PubMed
  2. Smedema JP, Müller GJ. Coronary spasm and thrombosis in a bodybuilder using a nutritional supplement containing synephrine, octopamine, tyramine and caffeine. S Afr Med J. 2008;98(5):372-3.
  3. Gilliam LK, Palmer JP, Taborsky GJ Jr. Tyramine-mediated activation of sympathetic nerves inhibits insulin secretion in humans. J Clin Endocrinol Metab. 2007;92(10):4035-8. PubMed
  4. VanDenBerg CM, Blob LF, Kemper EM, Azzaro AJ. Tyramine pharmacokinetics and reduced bioavailability with food. J Clin Pharmacol. 2003;43(6):604-9. DOI
  5. Meck JV, Martin DS, D'Aunno DS, Waters WW. Pressor response to intravenous tyramine is a marker of cardiac, but not vascular, adrenergic function. J Cardiovasc Pharmacol. 2003;41(1):126-31. PubMed
  6. Peet M, Yates RA, Carroll JA, Middlemiss DN. The interaction of tyramine with a single dose of tranylcypromine in healthy volunteers. Br J Clin Pharmacol. 1981;11(2):212-4. PubMed
  7. Del Rio B, Redruello B, Linares DM, et al. The dietary biogenic amines tyramine and histamine show synergistic toxicity towards intestinal cells in culture. Food Chem. 2017;218:249-255. PubMed
  8. Linares DM, del Rio B, Redruello B, et al. Comparative analysis of the in vitro cytotoxicity of the dietary biogenic amines tyramine and histamine. Food Chem. 2016;197(Pt A):658-63. PubMed
  9. National Institutes of Health. Dietary Supplement Label Database. http://www.dsld.nlm.nih.gov/dsld/rptQSearch.jsp?item=tyramine&db=adsld. Accessed October 23, 2019.
  10. Rapaport MH. Dietary restrictions and drug interactions with monoamine oxidase inhibitors: the state of the art. J Clin Psychiatry. 2007;68 Suppl 8:42-6.
  11. Colombo F, Porro T, del Rosso G, Bertalero P, Orlandi L, Libretti A. Cardiovascular responses to physical exercise and tyramine infusion in hypertensive and normotensive subjects. J Hum Hypertens. 1989;3(4):245-9.
  12. Pace DG, Reele SB, Rozik LM, Rogers-Phillips CA, Dabice JA, Givens SV. Evaluation of methods of administering tyramine to raise systolic blood pressure. Clin Pharmacol Ther. 1988;44(2):137-44. PubMed
  13. Caston JC, Eaton CL, Gheorghiu BP, Ware LL. Tyramine induced hypertensive episodes and panic attacks in hereditary deficient monoamine oxidase patients: case reports. J S C Med Assoc. 2002;98(4):187-92.
  14. European Food Safety Authority. Scientific opinion on risk based control of biogenic amine formation in fermented foods. EFSA Journal. 2011;9(10):2393. DOI
  15. Rafehi M, Faltraco F, Matthaei J, et al. Highly variable pharmacokinetics of tyramine in humans and polymorphisms in OCT1, CYP2D6, and MAO-A. Front Pharmacol. 2019 Oct 30;10:1297. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tyramine and Sorafenib Together: Common Questions

Is it safe to take Tyramine with Sorafenib?
We do not list a known interaction between Tyramine and Sorafenib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tyramine and Sorafenib have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Tyramine and Sorafenib at the same time of day?
At least one FDA label for a product containing Sorafenib says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Sorafenib on its own and move Tyramine to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Tyramine and Sorafenib combination checked?
Interactions in our licensed database are recorded against drug classes. Sorafenib is filed under 4 classifications, and Tyramine has documented interactions with 4 drug classes — none of Sorafenib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Tyramine interact with any other medications?
Yes. Tyramine has 353 documented drug interactions in our database — Sorafenib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sorafenib interact with any supplements?
Yes. Sorafenib has documented interactions with 285 supplements in our database — Tyramine is not one of them. The Sorafenib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tyramine monograph Uses, safety profile, and every drug interaction in one place Sorafenib drug information The full plain-English guide to this medication Sorafenib supplement interactions Every supplement checked against Sorafenib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 15 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sorafenib and Tyramine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.