Tyramine - Hydralazine, Hydrochlorothiazide, Reserpine Interaction

Interaction Details

Hydralazine, Hydrochlorothiazide, Reserpine is classified as belonging to the following category: Antihypertensive Drugs

Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.
In humans, oral and intravenous tyramine increases systolic blood pressure.

Interaction Rating

Likelihood of Occurrence

Well-controlled human studies have demonstrated the likely existence of this interaction

References

• Gilliam LK, Palmer JP, Taborsky GJ Jr. Tyramine-mediated activation of sympathetic nerves inhibits insulin secretion in humans. J Clin Endocrinol Metab. 2007;92(10):4035-8.
• VanDenBerg CM, Blob LF, Kemper EM, Azzaro AJ. Tyramine pharmacokinetics and reduced bioavailability with food. J Clin Pharmacol. 2003;43(6):604-9.
• Meck JV, Martin DS, D'Aunno DS, Waters WW. Pressor response to intravenous tyramine is a marker of cardiac, but not vascular, adrenergic function. J Cardiovasc Pharmacol. 2003;41(1):126-31.
• Colombo F, Porro T, del Rosso G, Bertalero P, Orlandi L, Libretti A. Cardiovascular responses to physical exercise and tyramine infusion in hypertensive and normotensive subjects. J Hum Hypertens. 1989;3(4):245-9.
• Pace DG, Reele SB, Rozik LM, Rogers-Phillips CA, Dabice JA, Givens SV. Evaluation of methods of administering tyramine to raise systolic blood pressure. Clin Pharmacol Ther. 1988;44(2):137-44.

Tyramine - More Interactions

Tyramine interacts with 349 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.