Medication interaction hub

What Supplements Interact with Azilsartan?

Azilsartan brand name: Edarbi. Every interaction below applies to the brands too.

182 Interactions 4 Major 145 Moderate 33 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Azilsartan? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Azilsartan against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Edarbi (azilsartan) lowers blood pressure, and its users are often the same shoppers browsing supplements sold for heart health, which makes this list of 182 ingredients one to treat with real care. Start with the four rated major: activated charcoal can soak up an oral dose before it absorbs, tyramine can push pressure up and blunt the drug, and two toxic botanicals carry documented heart risks of their own.

Past the majors, the big pattern is additive pressure lowering. Most of the 145 moderate and 33 minor entries can deepen azilsartan's effect or sometimes fight it, and 17, led by charcoal, can blunt absorption and belong spaced apart from each dose. A cluster of 64 can change how the liver clears the drug through CYP2C9, the enzyme that breaks it down. Potassium matters too, since ARBs already hold potassium in the body and a supplement on top can push blood levels too high.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 145 Minor 33 No known interaction 1,270

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Azilsartan: Top Interactions at a Glance

The Azilsartan supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 182 interacting ingredients — plus 1,270 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Azilsartan Combinations Today

The Azilsartan + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Sodium + Azilsartani

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Read the full interaction Moderate Likelihood Probable Fish Oil + Azilsartani

Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Minor Likelihood Possible Coenzyme Q10 + Azilsartani

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Read the full interaction Minor Likelihood Unlikely Grape + Azilsartani

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.

Read the full interaction Minor Likelihood Unlikely Cranberry + Azilsartani

Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.

Read the full interaction Moderate Likelihood Likely Potassium + Azilsartani

Using ARBs with high doses of potassium increases the risk of hyperkalemia.

Read the full interaction
The complete list

Every Supplement Checked Against Azilsartan

All 1,452 ingredients in our database, ranked by severity — 182 with a Azilsartan interaction on file and 1,270 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Azilsartan?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Sodium with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Full Sodium + Azilsartan answer

Can you take Fish Oil with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Azilsartan answer

Can you take Coenzyme Q10 with Azilsartan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Full Coenzyme Q10 + Azilsartan answer

Can you take Grape with Azilsartan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.

Full Grape + Azilsartan answer

Can you take Cranberry with Azilsartan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.

Full Cranberry + Azilsartan answer

Can you take Coriander with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.

Full Coriander + Azilsartan answer

Can you take Corn Silk with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking corn silk extract with antihypertensive drugs might increase the risk of hypotension.

Full Corn Silk + Azilsartan answer

Can you take Corydalis Yanhusuo with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might have additive effects with antihypertensive drugs.

Full Corydalis Yanhusuo + Azilsartan answer

Can you take Danshen with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking danshen with antihypertensive drugs might increase the risk of hypotension.

Full Danshen + Azilsartan answer

Can you take Devil's Claw with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C9.

Full Devil's Claw + Azilsartan answer

Can you take Diosmin with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP2C9 substrates.

Full Diosmin + Azilsartan answer

Can you take Eleuthero with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.

Full Eleuthero + Azilsartan answer

Can you take Eucalyptus with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP2C9 substrates.

Full Eucalyptus + Azilsartan answer

Can you take European Barberry with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking European barberry with antihypertensive drugs might increase the risk of hypotension.

Full European Barberry + Azilsartan answer

Can you take European Mistletoe with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European mistletoe might increase the risk of hypotension when taken with antihypertensive drugs.

Full European Mistletoe + Azilsartan answer

Can you take Fermented Milk with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fermented milk might increase the risk of hypotension when taken with antihypertensive drugs.

Full Fermented Milk + Azilsartan answer

Can you take Feverfew with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.

Full Feverfew + Azilsartan answer

Can you take Flaxseed with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Full Flaxseed + Azilsartan answer

Can you take Flaxseed Oil with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.

Full Flaxseed Oil + Azilsartan answer

Can you take Fo-ti with Azilsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2C9.

Full Fo-ti + Azilsartan answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Azilsartan is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Azilsartan, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Azilsartan sits in 4 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Azilsartan through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Azilsartan through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Azilsartan through this category.

Angiotensin Receptor Blockers (Arbs) 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Azilsartan through this category.

About Azilsartan

Azilsartan is an angiotensin II receptor antagonist used to treat high blood pressure.

Generic name: Azilsartan  ·  Brand name: Edarbi.

See the full Azilsartan drug information

Related: does Azilsartan deplete any nutrients?

Azilsartan has 1 reported nutrient association in the research literature — see the Azilsartan nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Azilsartan

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Azilsartan.

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Products that contain Azilsartan-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Azilsartan.

TNT Thermanite by GEC Genetic Edge Compounds contains Tyramine Diablos ECA Fire Caps by Innovative Laboratories contains Tyramine Ultimate Burn by Schwartz Laboratories contains Tyramine Final Cutz by Infinite Labs contains Tyramine
Pharmacist Counseling Corner

Azilsartan & Supplements: Common Questions

What supplements interact with Azilsartan?
Our database currently documents 182 ingredients with a known Azilsartan interaction (4 major, 145 moderate, 33 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 182. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Azilsartan supplement interactions are the most serious?
The 4 major-rated combinations — led by American Hellebore, Tyramine, Activated Charcoal and American Mistletoe — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Azilsartan?
Plenty of supplements coexist fine with Azilsartan; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Edarbi have the same supplement interactions as Azilsartan?
Yes — Edarbi all contain Azilsartan, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Azilsartan deplete any vitamins or nutrients?
It might — Azilsartan has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Azilsartan nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Azilsartan and my other medications?
This page covers Azilsartan against supplements and herbal ingredients. Checking Azilsartan against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Azilsartan drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.