Drug & supplement interaction

Coconut Water + Azilsartan

Azilsartan brand name: Edarbi.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Coconut Water has a moderate interaction with Azilsartan. Theoretically, taking coconut water with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Coconut Water and Azilsartan

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIHYPERTENSIVE DRUGS

Why this applies to Azilsartan

Azilsartan falls under ANTIHYPERTENSIVE DRUGS — the group Coconut Water interacts with.

Theoretically, taking coconut water with antihypertensive drugs might increase the risk of hypotension.
Preliminary clinical research shows that drinking coconut water might lower systolic and diastolic blood pressure in patients with hypertension.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the deal with azilsartan (Edarbi) and coconut water. Azilsartan already lowers your blood pressure by relaxing your blood vessels. Some early research hints that coconut water may nudge blood pressure down a little too, so drinking a lot of it could, in theory, add to that effect.

If your pressure dips too low, you might feel dizzy, lightheaded, tired, or a bit faint, especially when standing up quickly. To be honest, this is a theoretical concern based on how things work, not a strong, proven interaction. An occasional glass with your meal is unlikely to cause trouble. There's another angle too: coconut water is rich in potassium, and azilsartan can already raise potassium, so heavy intake deserves a quick word with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Alleyne T, Roache S, Thomas C, Shirley A. The control of hypertension by use of coconut water and mauby: two tropical food drinks. West Indian Med J 2005;54:3-8. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Coconut Water Also Interacts With Other Medications

Coconut Water has 192 moderate, 86 minor known drug interactions in our database — the Azilsartan one above is one of them. If you take anything else, check it against the full list below.

Moderate 192 Minor 86 No known interaction 2,552 (incl. Azilsartan)
Taking anything else?

Check Another of Your Medications Against Coconut Water

Covers the 2,830 medications we’ve checked against Coconut Water. Pick one to open its full report.

From our Q&A

Questions About Coconut Water or Azilsartan

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Coconut Water or Azilsartan, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Azilsartan

This page covers Coconut Water only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Azilsartan page lists 182 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Tyramine (major) and Adrafinil (moderate).

By severity: 4 major · 145 moderate · 33 minor.

From our pharmacist’s overview on the Azilsartan page

“Edarbi (azilsartan) lowers blood pressure, and its users are often the same shoppers browsing supplements sold for heart health, which makes this list of 182 ingredients one to treat with real care. Start with the four rated major: activated charcoal can soak up an oral dose before it absorbs, tyramine can push pressure up and blunt th…”

Reviewed by 2 · Jul 18, 2026

Open the Azilsartan interaction page

One more smart check

Taking Coconut Water as Part of a Dietary Supplement Product? Check It for Interactions

We hold 67 real supplement products containing Coconut Water, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Coconut Water. Your product may carry other ingredients that interact with Azilsartan too, on top of Coconut Water — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Coconut Water and Azilsartan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coconut Water
Top half

#410 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Azilsartan
Steady interest

#1,554 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Coconut Water

What is Coconut Water?

Coconut Water
  • Hydration
  • Rehydration after exercise
  • Electrolyte replacement
  • General wellness drink
  • Blood pressure support

Coconut water is a natural drink rich in potassium and other electrolytes that many people use for hydration, especially around exercise. For most healthy people it is a safe, tasty beverage, but it is not a proven medicine and should not replace medical electrolyte solutions for serious dehydration. People with kidney disease or those on potassium-affecting medicines should check with their pharmacist or doctor first.

Read the full Coconut Water monograph & all interactions
Medication

About Azilsartan

What Is Azilsartan Used For?

Brand name: Edarbi

Azilsartan medoxomil tablets — sold as both the generic Azilsartan Medoxomil and the brand Edarbi — are approved to treat high blood pressure (hypertension) in adults. Bringing blood pressure down lowers the risk of serious cardiovascular events, especially stroke and heart attack.

The medication can be used on its own or alongside other blood pressure medicines. It is not a cure for high blood pressure, and managing the condition fully often involves lifestyle steps like limiting sodium, exercising, and quitting smoking.

See full Azilsartan drug information
Keep checking

Other Drugs & Coconut Water

Browse every other medication we’ve checked against Coconut Water — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
192Moderate
86Minor
2,551No known interaction
192 Moderate 86 Minor 2,551 No interaction
Moderate

192 interactions

Showing 60 of 192 moderate interactions — see all 192 on the Coconut Water page.

Minor

86 interactions

Showing 60 of 86 minor interactions — see all 86 on the Coconut Water page.

No interaction 2,551 drugs checked — show the list

We also checked Coconut Water against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,551 medications checked with no known interaction — see the full Coconut Water list.

See the full Coconut Water interactions page
See every supplement checked against Azilsartan, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Coconut Water monograph › Uses, safety, and every drug interaction in one place Azilsartan supplement interactions › Every supplement checked against Azilsartan, ranked by severity Azilsartan drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Coconut Water and Azilsartan Together: Common Questions

Can you take Coconut Water with Azilsartan?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Coconut Water and Azilsartan interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Azilsartan and Coconut Water?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.