Drug & supplement interaction

Euphorbia Hirta + Azilsartan

Azilsartan brand name: Edarbi.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Euphorbia Hirta and Azilsartan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Euphorbia Hirta and Azilsartan

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Azilsartan and Euphorbia Hirta in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Euphorbia Hirta at all — not against Azilsartan, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Euphorbia Hirta safety at a glance

Euphorbia Hirta overall Use caution Human safety data are very limited, so use carefully and under professional guidance.
Pregnancy Possibly Unsafe When used orally; avoid using. Euphorbia hirta is reported to cause smooth muscle contraction and relaxation. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally; avoid using. Euphorbia hirta is reported to cause smooth muscle contraction and relaxation. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Azilsartan and Euphorbia Hirta? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Euphorbia Hirta and Azilsartan May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Euphorbia Hirta

    “There is currently a limited amount of information available about the adverse effects of Euphorbia hirta. Orally, Euphorbia hirta may cause nausea and vomiting (12). Topically, skin contact with fresh Euphorbia hirta can cause irritation or contact dermatitis (19).”

    Euphorbia Hirta · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

    “Topically, skin contact with fresh Euphorbia hirta can cause irritation or contact dermatitis (19).”

    Euphorbia Hirta · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

    Azilsartan

    Listed in the ADVERSE REACTIONS section of the FDA label for Azilsartan. Read the label on DailyMed ›

  • Nausea reported in 4.5% of FDA reports for Azilsartan Additional detail

    Euphorbia Hirta

    “Orally, Euphorbia hirta may cause nausea and vomiting (12).”

    Euphorbia Hirta · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

    Azilsartan

    Listed in the ADVERSE REACTIONS section of the FDA label for Azilsartan, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Euphorbia Hirta but not commonly for Azilsartan: vomiting.

Effects for Azilsartan come from the ADVERSE REACTIONS section of its FDA label; effects for Euphorbia Hirta come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 4,183 voluntary FDA FAERS reports for Azilsartan that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Euphorbia Hirta in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally; avoid using. Euphorbia hirta is reported to cause smooth muscle contraction and relaxation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Euphorbia Hirta or Azilsartan

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Euphorbia Hirta or Azilsartan, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Azilsartan

This page covers Euphorbia Hirta only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Azilsartan page lists 182 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Tyramine (major) and Adrafinil (moderate).

By severity: 4 major · 145 moderate · 33 minor.

From our pharmacist’s overview on the Azilsartan page

“Edarbi (azilsartan) lowers blood pressure, and its users are often the same shoppers browsing supplements sold for heart health, which makes this list of 182 ingredients one to treat with real care. Start with the four rated major: activated charcoal can soak up an oral dose before it absorbs, tyramine can push pressure up and blunt th…”

Reviewed by 2 · Jul 18, 2026

Open the Azilsartan interaction page

How much people look this up

Where Euphorbia Hirta and Azilsartan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Euphorbia Hirta
Steady interest

#1,067 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Azilsartan
Steady interest

#1,534 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Euphorbia Hirta reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Euphorbia Hirta and Azilsartan records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Euphorbia Hirta

What is Euphorbia Hirta?

  • Respiratory complaints like asthma and cough
  • Diarrhea and digestive upset
  • Skin wounds and warts
  • Worms and other parasites
  • General antimicrobial use

Euphorbia hirta is a small tropical weed used in traditional medicine for breathing problems, diarrhea, and skin issues. Most of its supposed benefits come from laboratory or animal studies rather than solid human trials, so its true effectiveness in people is unclear. Because its safety is not well studied, talk to a pharmacist or doctor before using it.

Euphorbia hirta · Euphorbiaceae · Whole plant (leaves, stems, flowers, and latex) · Dried herb, tea/decoction, tincture, capsules, and topical extracts

An interaction check asks whether these two react with each other — it does not ask whether Euphorbia Hirta is a good idea for someone in your situation. Here is what our Euphorbia Hirta record says about it on its own.

Euphorbia Hirta: dosing

There is no standardized or well-established dose for Euphorbia hirta. Traditional preparations vary widely depending on the form (tea, juice, tincture, or capsule) and the region.Because product strength and purity can differ a lot between brands, follow the directions on the product label and do not exceed them.

From our Euphorbia Hirta monograph — the full record covers uses, side effects and every documented interaction.

Read the full Euphorbia Hirta monograph & all interactions
Medication

About Azilsartan

What Is Azilsartan Used For?

Brand name: Edarbi

Azilsartan medoxomil tablets — sold as both the generic Azilsartan Medoxomil and the brand Edarbi — are approved to treat high blood pressure (hypertension) in adults. Bringing blood pressure down lowers the risk of serious cardiovascular events, especially stroke and heart attack.

The medication can be used on its own or alongside other blood pressure medicines. It is not a cure for high blood pressure, and managing the condition fully often involves lifestyle steps like limiting sodium, exercising, and quitting smoking.

Most-Reported Side Effects for Azilsartan

From FAERS, the FDA’s public side-effect reporting system (4,183 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dizziness 231 reports
Diarrhea 226 reports
Hypertension 215 reports
Nausea 187 reports
Fatigue 182 reports
See full Azilsartan drug information
Keep checking

Other Drugs & Euphorbia Hirta

Browse every other medication we’ve checked against Euphorbia Hirta — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Euphorbia Hirta against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Euphorbia Hirta list.

See the full Euphorbia Hirta interactions page
See every supplement checked against Azilsartan, ranked by severity
Evidence & sources

Euphorbia Hirta References

The 3 references that drive our Euphorbia Hirta monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Euphorbia Hirta and Azilsartan Together: Common Questions

Is it safe to take Euphorbia Hirta with Azilsartan?
We do not list a known interaction between Euphorbia Hirta and Azilsartan. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Euphorbia Hirta and Azilsartan have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Azilsartan interact with any supplements?
Yes. Azilsartan has documented interactions with 182 supplements in our database — Euphorbia Hirta is not one of them. The Azilsartan interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Euphorbia Hirta monograph Uses, safety profile, and every drug interaction in one place Azilsartan drug information The full plain-English guide to this medication Azilsartan supplement interactions Every supplement checked against Azilsartan, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Azilsartan and Euphorbia Hirta?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.