Hyland's Restless Legs - Entresto (Sacubitril, Valsartan) Interaction
Herbal: Hyland's Restless Legs
Drug: Sacubitril, Valsartan
Brand names:
Entresto
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 22, 2025
Interaction Details
There were no interactions found between Sacubitril, Valsartan and Hyland's Restless Legs. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Pharmacist Analysis
In most situations, clinically significant interactions between homeopathic products and prescription or over-the-counter medications are extremely unlikely.
Homeopathic medications, which utilize the principle of 'like cures like', are often highly diluted substances. These dilutions are typically so high that the final remedy contains only a tiny amount of the original active ingredient, if any at all.
In theory, because the concentration of the active ingredient is so low, homeopathic preparations are unlikely to interact with other medications in the body.
This is certainly the case with Hyland's Restful Legs, with all the ingredients diluted at potencies of 6X or 12X. A potency of 6X means that the original substance has been diluted by a factor of 10^6, or one part in a million (i.e., for every million parts of the solution, there is one part of the original substance).
It is important to note that not all homeopathic remedies are free of potential drug interactions as some use very low dilutions (which is often the case with zinc-containing products).
Nevertheless, there are no known drug interactions between Hyland's Restful Legs and other medications. It is also thought to be safe to take along with medications to help sleep, like Benadryl, melatonin, and NyQuil, which are commonly used with the product to help sleep.
- Dr. Brian Staiger, PharmDHyland's Restless Legs Overview
Hyland's Restless Legs (the actual product name is Hyland's Restful Legs but it is more commonly known as 'restless legs') is a homeopathic product that is marketed to 'calm agitated legs so you can rest.' As a homeopathic product, Restul Legs is based on the principle of "like cures like" or 'law of similars', meaning that a substance that causes symptoms in a healthy person can be used in a diluted form to treat similar symptoms (such as an onion preparation being used to treat watery eyes and a runny nose). A good example of this is that Restful Legs contain Arsenicum Album 12X, a highly diluted form of arsenic. There is both a daytime version of Hyland's Restless Legs and a nighttime version (PM).
Sacubitril, Valsartan Overview
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The combination of valsartan and sacubitril is usually used in combination with other medications to lower the risk of death and hospitalization in adults with certain types of heart failure. The combination of valsartan and sacubitril is also used to treat certain types of heart failure in children 1 year of age and older. Valsartan is in a class of medications called angiotensin II receptor antagonists. It works by blocking the action of certain natural substances that tighten the blood vessels, allowing the blood to flow more smoothly and the heart to pump more efficiently. Sacubitril is in a class of medications called neprilysin inhibitors. It works to help control blood volume.
Hyland's Restless Legs - More Interactions
Hyland's Restless Legs interacts with 0 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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