Dragon's Blood + Sacubitril, Valsartan
Sacubitril, Valsartan brand name: Entresto.
We found no known interaction between Dragon's Blood and Sacubitril, Valsartan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Dragon's Blood and Sacubitril, Valsartan
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Sacubitril, Valsartan and Dragon's Blood in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Dragon's Blood at all — not against Sacubitril, Valsartan, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Dragon's Blood safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Sacubitril, Valsartan
This page covers Dragon's Blood only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sacubitril, Valsartan page lists 249 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Lithium (major) and Oleander (major).
By severity: 7 major · 206 moderate · 36 minor.
From our pharmacist’s overview on the Sacubitril, Valsartan page
“Entresto (sacubitril and valsartan) is a heart failure medicine, and heart failure patients tend to be heavy supplement users, reaching for fish oil, potassium, and herbal blood-pressure remedies. That instinct carries real risk here.”
Reviewed by 2 · Jul 18, 2026
Taking Dragon's Blood as Part of a Dietary Supplement Product? Check It for Interactions
We hold 21 real supplement products containing Dragon's Blood, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dragon's Blood. Even though Dragon's Blood itself has no known interaction with Sacubitril, Valsartan, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Dragon's Blood and Sacubitril, Valsartan Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,300 of 1,452 supplements looked up here in the last 7 days
#185 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Dragon's Blood is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dragon's Blood reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Dragon's Blood and Sacubitril, Valsartan records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Dragon's Blood
What is Dragon's Blood?
- Wound healing and skin care
- Digestive upset and diarrhea
- Minor cuts and insect bites
- Sore throat and mouth sores
- Anti-inflammatory skincare
Dragon's Blood is a red plant resin used in traditional medicine for wound healing, skin problems, and digestive complaints. Some early research on certain types (especially Croton lechleri "Sangre de Drago") is promising for the gut and skin, but high-quality human evidence is limited. Talk with your pharmacist or doctor before using it, especially while pregnant or breastfeeding.
Red resin (sap) from the bark, stem, or fruit, depending on the source plant · Resin powder, capsules, tinctures, topical liquids, creams, and skincare products
An interaction check asks whether these two react with each other — it does not ask whether Dragon's Blood is a good idea for someone in your situation. Here is what our Dragon's Blood record says about it on its own.
Dragon's Blood: dosing
There is no established standard dose for Dragon's Blood. The right amount depends on the specific plant source, the product type (resin, tincture, capsule, or cream), and how it is being used.If you choose to use a Dragon's Blood product, follow the directions on the label and do not exceed the suggested amount.
From our Dragon's Blood monograph — the full record covers uses, side effects and every documented interaction.
About Valsartan and Sacubitril
What Is Valsartan and Sacubitril Used For?
Brand name: Entresto
Sacubitril and valsartan is used to reduce the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure. The benefit is most clearly seen in patients whose heart pumps with a lower-than-normal ejection fraction (the percentage of blood the heart pushes out with each beat).
It is also approved to treat symptomatic heart failure with reduced left ventricular function in children aged 1 year and older. In pediatric patients, it lowers a blood marker of heart stress (NT-proBNP) and is expected to improve heart outcomes.
Other Drugs & Dragon's Blood
Browse every other medication we’ve checked against Dragon's Blood — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Dragon's Blood against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Ivermectin ›
- Abemaciclib ›
- Testosterone ›
- Losartan Potassium ›
- Sertraline ›
- Acetaminophen ›
- Rosuvastatin ›
- Aspirin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Ibuprofen ›
- Warfarin Sodium ›
- Amlodipine Besylate ›
- Levothyroxine, Liothyronine ›
- Docusate ›
- Methamphetamine ›
- Prednisone ›
- Metformin ›
- Amitriptyline ›
- Tadalafil ›
- Semaglutide ›
- Lisdexamfetamine ›
- Hydroxyurea ›
- Valacyclovir ›
- Amphetamine ›
- Sumatriptan ›
- Propranolol ›
- Methotrexate ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Pregabalin ›
- Doxycycline ›
- Gabapentin ›
- Acetaminophen, Aspirin, Caffeine ›
- Dextroamphetamine ›
- Naproxen ›
- Lamotrigine ›
- Bendamustine ›
- Quetiapine ›
- Clonazepam ›
- Acyclovir ›
- Buspirone ›
- Duloxetine ›
- Omeprazole ›
- Letrozole ›
- Citalopram ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Dragon's Blood list.
Dragon's Blood References
The 2 sources that drive our Dragon's Blood monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Dragon's Blood is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Sacubitril, Valsartan Is Linked to Lower Levels of 7 Nutrients
Natural Medicines records Sacubitril, Valsartan as a medicine that can lower these. This is not an interaction with Dragon's Blood — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Sacubitril, Valsartan nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Dragon's Blood and Sacubitril, Valsartan Together: Common Questions
Is it safe to take Dragon's Blood with Sacubitril, Valsartan?
Does Sacubitril, Valsartan interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.