Rupturewort + Linagliptin, Metformin Hydrochloride
Linagliptin, Metformin Hydrochloride brand name: Jentadueto XR.
We found no known interaction between Rupturewort and Linagliptin, Metformin Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Linagliptin, Metformin Hydrochloride states a food rule worth keeping to.
Rupturewort and Linagliptin, Metformin Hydrochloride
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Linagliptin, Metformin Hydrochloride and Rupturewort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Rupturewort safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Linagliptin, Metformin Hydrochloride
Interactions in our licensed database are recorded against drug classes, not just single drug names. Linagliptin, Metformin Hydrochloride is filed under 6 classifications — including organic cation transporter 2 (oct2) substrates, antidiabetes drugs, cytochrome p450 3a4 (cyp3a4) inhibitors. Rupturewort has documented interactions with 1 drug class — the most serious being lithium (moderate) — and none of Linagliptin, Metformin Hydrochloride’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Rupturewort Does Interact With Other Medications
Rupturewort has 1 moderate known drug interaction in our database — Linagliptin, Metformin Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Rupturewort
We haven’t checked that one against Rupturewort yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Rupturewort. Pick one to open its full report.
Some Linagliptin, Metformin Hydrochloride Products Have a Food Rule — Rupturewort Should Not Break It
At least one FDA label for a product containing Linagliptin, Metformin Hydrochloride says to take it with food. If you take Rupturewort on an empty stomach out of habit, keep them separate — and take Linagliptin, Metformin Hydrochloride with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Linagliptin, Metformin Hydrochloride products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
2 DOSAGE AND ADMINISTRATION Individualize the starting dosage of JENTADUETO XR based on the patient's current regimen ( 2.1 ) The maximum recommended dosage is 5 mg linagliptin/2,000 mg metformin HCl once daily ( 2.1 ) Take orally once daily with a meal, with gradual dose escalation to reduce the gastrointestinal effects due to metformin ( 2.1 ) Swallow whole; do not split, crush, dissolve, or che
From the Dosage and Administration section of the FDA label we read for Linagliptin, Metformin Hydrochloride — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Linagliptin, Metformin Hydrochloride
This page covers Rupturewort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Linagliptin, Metformin Hydrochloride page lists 285 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), St. John's Wort (major), Acai (moderate) and Adrafinil (moderate).
By severity: 3 major · 242 moderate · 40 minor.
From our pharmacist’s overview on the Linagliptin, Metformin Hydrochloride page
“Someone taking Jentadueto XR (linagliptin and metformin) for type 2 diabetes is often the same person eyeing fenugreek, bitter melon, or gymnema, and that overlap is why this page deserves real caution. Of its 285 ingredients, 239 can lower blood sugar on their own, so stacking them on a drug already doing that job risks pushing glucos…”
Reviewed by 2 · Jul 18, 2026
Open the Linagliptin, Metformin Hydrochloride interaction page
Taking Rupturewort as Part of a Dietary Supplement Product? Check It for Interactions
We hold 19 real supplement products containing Rupturewort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rupturewort. Even though Rupturewort itself has no known interaction with Linagliptin, Metformin Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Rupturewort and Linagliptin, Metformin Hydrochloride Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#791 of 1,452 supplements looked up here in the last 7 days
#1,103 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rupturewort reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Rupturewort and Linagliptin, Metformin Hydrochloride records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Rupturewort
What is Rupturewort?
- Urinary tract complaints
- Mild fluid retention (as a diuretic)
- Kidney and bladder support
- Wound healing and inflammation (topical, traditional)
- Spasms or cramping (traditional)
Rupturewort is a traditional European herb mainly used as a mild diuretic and for urinary complaints. Solid human research is very limited, so its true benefits and long-term safety are not well established. Talk to a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
Herniaria glabra · Caryophyllaceae · Aerial parts (the above-ground flowering herb) · Tea, dried herb, tincture, capsules
An interaction check asks whether these two react with each other — it does not ask whether Rupturewort is a good idea for someone in your situation. Here is what our Rupturewort record says about it on its own.
Rupturewort: dosing
There is no well-established or standardized dose for rupturewort. Traditional use involves brewing the dried herb as a tea, but reliable dosing guidance from clinical research does not exist.If you choose to use a product, follow the directions on the label and do not exceed them.
From our Rupturewort monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Rupturewort
Browse every other medication we’ve checked against Rupturewort — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1 interaction
No interaction 2,828 drugs checked — show the list
We also checked Rupturewort against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Rivaroxaban ›
- Aspirin ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Abemaciclib ›
- Clopidogrel ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Tirzepatide ›
- Valacyclovir ›
- Ibuprofen ›
- Hydroxyurea ›
- Methamphetamine ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Amitriptyline ›
- Bendamustine ›
- Methotrexate ›
- Acyclovir ›
- Doxycycline ›
- Amphetamine ›
- Isotretinoin ›
- Fluoxetine ›
- Lamotrigine ›
- Pregabalin ›
- Azithromycin ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amlodipine Besylate ›
- Dextroamphetamine ›
- Clonazepam ›
- Methylene Blue ›
- Quetiapine ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Rupturewort list.
Rupturewort References
The 1 references that drive our Rupturewort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Hakim EM, Sivak KV, Kaukhova IE. Evaluation of the diuretic effect of crude ethanol and saponin-rich extracts of Herniaria glabra L. in rats. J Ethnopharmacol. 2021 Jun 12;273:113942. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Linagliptin, Metformin Hydrochloride Is Linked to Lower Levels of 4 Nutrients
Natural Medicines records Linagliptin, Metformin Hydrochloride as a medicine that can lower these. This is not an interaction with Rupturewort — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Linagliptin, Metformin Hydrochloride nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Rupturewort and Linagliptin, Metformin Hydrochloride Together: Common Questions
Is it safe to take Rupturewort with Linagliptin, Metformin Hydrochloride?
Should I take Rupturewort and Linagliptin, Metformin Hydrochloride at the same time of day?
How was the Rupturewort and Linagliptin, Metformin Hydrochloride combination checked?
Does Rupturewort interact with any other medications?
Does Linagliptin, Metformin Hydrochloride interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.