Medication interaction hub

What Supplements Interact with Linagliptin, Metformin Hydrochloride?

Linagliptin, Metformin Hydrochloride brand name: Jentadueto XR. Every interaction below applies to the brands too.

285 Interactions 3 Major 242 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Linagliptin, Metformin Hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Linagliptin, Metformin Hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Someone taking Jentadueto XR (linagliptin and metformin) for type 2 diabetes is often the same person eyeing fenugreek, bitter melon, or gymnema, and that overlap is why this page deserves real caution. Of its 285 ingredients, 239 can lower blood sugar on their own, so stacking them on a drug already doing that job risks pushing glucose dangerously low. Three rate major, led by Siberian cocklebur, which has caused severe drops in blood sugar soon after people ate it.

The other two majors act differently. St. John's wort speeds linagliptin out of the body by revving up a transport protein, and activated charcoal can bind the medication in the gut before it absorbs. Behind them sit 242 moderate and 40 minor entries, many everyday items like flaxseed and even beer, which can unsettle glucose control. If you try one, learn the low-sugar signs, shakiness, sweating, confusion, and check your glucose more often at first.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 242 Minor 40 No known interaction 1,167

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Linagliptin, Metformin Hydrochloride: Top Interactions at a Glance

The Linagliptin, Metformin Hydrochloride supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 285 interacting ingredients — plus 1,167 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Linagliptin, Metformin Hydrochloride Combinations Today

The Linagliptin, Metformin Hydrochloride + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Vitamin B12 + Linagliptin, Metformin Hydrochloridei

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.

Read the full interaction Moderate Likelihood Possible Blond Psyllium + Linagliptin, Metformin Hydrochloridei

Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.

Read the full interaction Moderate Likelihood Possible Black Seed + Linagliptin, Metformin Hydrochloridei

Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Probable Ribose + Linagliptin, Metformin Hydrochloridei

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Tragacanth + Linagliptin, Metformin Hydrochloridei

Theoretically, tragacanth might alter absorption of oral drugs.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Linagliptin, Metformin Hydrochloridei

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.

Read the full interaction
The complete list

Every Supplement Checked Against Linagliptin, Metformin Hydrochloride

All 1,452 ingredients in our database, ranked by severity — 285 with a Linagliptin, Metformin Hydrochloride interaction on file and 1,167 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Linagliptin, Metformin Hydrochloride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin B12 with Linagliptin, Metformin Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.

Full Vitamin B12 + Linagliptin, Metformin Hydrochloride answer

Can you take Blond Psyllium with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.

Full Blond Psyllium + Linagliptin, Metformin Hydrochloride answer

Can you take Black Seed with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.

Full Black Seed + Linagliptin, Metformin Hydrochloride answer

Can you take Ribose with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.

Full Ribose + Linagliptin, Metformin Hydrochloride answer

Can you take Tragacanth with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Linagliptin, Metformin Hydrochloride answer

Can you take Ambrette with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of ambrette with antidiabetes drugs might increase the risk of hypoglycemia.

Full Ambrette + Linagliptin, Metformin Hydrochloride answer

Can you take Anise with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, anise seed might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Anise + Linagliptin, Metformin Hydrochloride answer

Can you take Annatto with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal studies suggest that certain annatto extracts may have hypoglycemic or hyperglycemic effects.

Full Annatto + Linagliptin, Metformin Hydrochloride answer

Can you take Apple with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.

Full Apple + Linagliptin, Metformin Hydrochloride answer

Can you take Arabinoxylan with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from human research suggests that an arabinoxylan-rich fiber can reduce postprandial glucose levels.

Full Arabinoxylan + Linagliptin, Metformin Hydrochloride answer

Can you take Artemisia Herba-alba with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with antidiabetes drugs might increase the risk of hypoglycemia.

Full Artemisia Herba-alba + Linagliptin, Metformin Hydrochloride answer

Can you take Artichoke with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Artichoke + Linagliptin, Metformin Hydrochloride answer

Can you take Ash with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.

Full Ash + Linagliptin, Metformin Hydrochloride answer

Can you take Ashwagandha with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.

Full Ashwagandha + Linagliptin, Metformin Hydrochloride answer

Can you take Avocado Sugar Extract with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, avocado sugar extract might increase blood glucose levels, and decrease the effects of antidiabetic agents.

Full Avocado Sugar Extract + Linagliptin, Metformin Hydrochloride answer

Can you take Ba Ji Tian with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that taking ba ji tian extracts might increase or decrease blood glucose levels.

Full Ba Ji Tian + Linagliptin, Metformin Hydrochloride answer

Can you take Bael with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that extracts of bael seed and leaf can reduce blood glucose levels.

Full Bael + Linagliptin, Metformin Hydrochloride answer

Can you take Baikal Skullcap with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Baikal skullcap with antidiabetes drugs might enhance blood glucose lowering effects.

Full Baikal Skullcap + Linagliptin, Metformin Hydrochloride answer

Can you take Bay Leaf with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of bay leaf with antidiabetes drugs might increase the risk of hypoglycemia.

Full Bay Leaf + Linagliptin, Metformin Hydrochloride answer

Can you take Berberine with Linagliptin, Metformin Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine may increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Berberine + Linagliptin, Metformin Hydrochloride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Linagliptin, Metformin Hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Linagliptin, Metformin Hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Linagliptin, Metformin Hydrochloride sits in 6 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Linagliptin, Metformin Hydrochloride through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Linagliptin, Metformin Hydrochloride through this category.

Metformin (Glucophage) 18 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

18 of the supplement ingredients on this page reach Linagliptin, Metformin Hydrochloride through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Linagliptin, Metformin Hydrochloride through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Linagliptin, Metformin Hydrochloride through this category.

Organic Cation Transporter 2 (Oct2) Substrates 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Linagliptin, Metformin Hydrochloride through this category.

Related: does Linagliptin, Metformin Hydrochloride deplete any nutrients?

Linagliptin, Metformin Hydrochloride has 4 reported nutrient associations in the research literature — see the Linagliptin, Metformin Hydrochloride nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Linagliptin, Metformin Hydrochloride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Linagliptin, Metformin Hydrochloride.

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Pharmacist Counseling Corner

Linagliptin, Metformin Hydrochloride & Supplements: Common Questions

What supplements interact with Linagliptin, Metformin Hydrochloride?
More than you might expect — 285 in total, though they are far from equal: 3 are rated major, 242 moderate, and 40 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, St. John's Wort.
Which Linagliptin, Metformin Hydrochloride supplement interactions are the most serious?
The 3 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Linagliptin, Metformin Hydrochloride?
Usually yes — most people on Linagliptin, Metformin Hydrochloride can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Jentadueto XR have the same supplement interactions as Linagliptin, Metformin Hydrochloride?
Yes — Jentadueto XR all contain Linagliptin, Metformin Hydrochloride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Linagliptin, Metformin Hydrochloride deplete any vitamins or nutrients?
It might — Linagliptin, Metformin Hydrochloride has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Linagliptin, Metformin Hydrochloride nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Linagliptin, Metformin Hydrochloride and my other medications?
This page covers Linagliptin, Metformin Hydrochloride against supplements and herbal ingredients. Checking Linagliptin, Metformin Hydrochloride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.