Kale + Linagliptin, Metformin Hydrochloride
Linagliptin, Metformin Hydrochloride brand name: Jentadueto XR.
We found no known interaction between Kale and Linagliptin, Metformin Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Linagliptin, Metformin Hydrochloride states a food rule worth keeping to.
Kale and Linagliptin, Metformin Hydrochloride
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Linagliptin, Metformin Hydrochloride and Kale in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Kale at all — not against Linagliptin, Metformin Hydrochloride, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Kale safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Kale in Pregnancy & Breastfeeding
When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of kale when used orally in medicinal amounts; avoid use.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Linagliptin, Metformin Hydrochloride Products Have a Food Rule — Kale Should Not Break It
At least one FDA label for a product containing Linagliptin, Metformin Hydrochloride says to take it with food. If you take Kale on an empty stomach out of habit, keep them separate — and take Linagliptin, Metformin Hydrochloride with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Linagliptin, Metformin Hydrochloride products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
2 DOSAGE AND ADMINISTRATION Individualize the starting dosage of JENTADUETO XR based on the patient's current regimen ( 2.1 ) The maximum recommended dosage is 5 mg linagliptin/2,000 mg metformin HCl once daily ( 2.1 ) Take orally once daily with a meal, with gradual dose escalation to reduce the gastrointestinal effects due to metformin ( 2.1 ) Swallow whole; do not split, crush, dissolve, or che
From the Dosage and Administration section of the FDA label we read for Linagliptin, Metformin Hydrochloride — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Linagliptin, Metformin Hydrochloride
This page covers Kale only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Linagliptin, Metformin Hydrochloride page lists 285 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), St. John's Wort (major), Acai (moderate) and Adrafinil (moderate).
By severity: 3 major · 242 moderate · 40 minor.
From our pharmacist’s overview on the Linagliptin, Metformin Hydrochloride page
“Someone taking Jentadueto XR (linagliptin and metformin) for type 2 diabetes is often the same person eyeing fenugreek, bitter melon, or gymnema, and that overlap is why this page deserves real caution. Of its 285 ingredients, 239 can lower blood sugar on their own, so stacking them on a drug already doing that job risks pushing glucos…”
Reviewed by 2 · Jul 18, 2026
Open the Linagliptin, Metformin Hydrochloride interaction page
Taking Kale as Part of a Dietary Supplement Product? Check It for Interactions
We hold 2,971 real supplement products containing Kale, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Kale. Even though Kale itself has no known interaction with Linagliptin, Metformin Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Kale and Linagliptin, Metformin Hydrochloride Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#103 of 1,452 supplements looked up here in the last 7 days
#672 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Kale is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Kale reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Kale and Linagliptin, Metformin Hydrochloride records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Kale
What is Kale?
- General nutrition and antioxidants
- Heart health support
- Eye health
- Bone health
- Digestive health and fiber
Kale is a nutrient-dense leafy green vegetable that is rich in vitamins, minerals, fiber, and antioxidants. Eaten as a normal food it is very healthy for most people, but it is a whole food rather than a proven treatment for any specific disease. People taking blood thinners or with thyroid concerns may need to be mindful of how much they eat.
Brassica oleracea var. acephala · Brassicaceae · Leaves · Fresh or cooked leaves, juice, powder, capsules, smoothies
An interaction check asks whether these two react with each other — it does not ask whether Kale is a good idea for someone in your situation. Here is what our Kale record says about it on its own.
Kale: dosing
There is no established 'dose' of kale because it is a food, not a standardized medicine. As a vegetable, it can be included as part of a balanced diet the way you would eat any leafy green.For kale powders, capsules, or juices, no proven therapeutic dose exists.
From our Kale monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Kale
Browse every other medication we’ve checked against Kale — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Kale against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Kale list.
Kale References
The 2 sources that drive our Kale monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Kale is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Vitamin K - Health Professional Fact Sheet — NIH Office of Dietary Supplements Source
- Lutein and Zeaxanthin — NIH Office of Dietary Supplements Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Linagliptin, Metformin Hydrochloride Is Linked to Lower Levels of 4 Nutrients
Natural Medicines records Linagliptin, Metformin Hydrochloride as a medicine that can lower these. This is not an interaction with Kale — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Linagliptin, Metformin Hydrochloride nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Kale and Linagliptin, Metformin Hydrochloride Together: Common Questions
Is it safe to take Kale with Linagliptin, Metformin Hydrochloride?
Should I take Kale and Linagliptin, Metformin Hydrochloride at the same time of day?
Does Linagliptin, Metformin Hydrochloride interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Linagliptin, Metformin Hydrochloride and Kale?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.