Drug & supplement interaction

Brewer's Yeast + Linagliptin, Metformin Hydrochloride

Linagliptin, Metformin Hydrochloride brand name: Jentadueto XR.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Brewer's Yeast has a moderate interaction with Linagliptin, Metformin Hydrochloride. Taking brewer's yeast with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Brewer's Yeast and Linagliptin, Metformin Hydrochloride

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Linagliptin, Metformin Hydrochloride

Linagliptin, Metformin Hydrochloride falls under ANTIDIABETES DRUGS — the group Brewer's Yeast interacts with.

Taking brewer's yeast with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking chromium-containing brewer's yeast can decrease levels of blood glucose in diabetic patients being treated with antidiabetes drugs.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with Jentadueto XR (which combines linagliptin and metformin to lower your blood sugar). Brewer's yeast naturally contains chromium, and some research suggests chromium can help nudge blood sugar down on its own. So if you take a brewer's yeast supplement regularly along with your diabetes medicine, the two could add up and push your sugar a little lower than expected.

In real life, that mostly matters as a higher chance of low blood sugar (hypoglycemia), with signs like shakiness, sweating, dizziness, hunger, or feeling foggy. This isn't a reason to panic, and small food amounts of yeast usually won't do much. Still, before starting a daily supplement, check with your pharmacist or doctor and keep an eye on your readings.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Bahijiri, S. M., Mira, S. A., Mufti, A. M., and Ajabnoor, M. A. The effects of inorganic chromium and brewer's yeast supplementation on glucose tolerance, serum lipids and drug dosage in individuals with type 2 diabetes. Saudi.Med.J. 2000;21(9):831-837. DOI

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Brewer's Yeast Also Interacts With Other Medications

Brewer's Yeast has 9 major, 86 moderate, 40 minor known drug interactions in our database — the Linagliptin, Metformin Hydrochloride one above is one of them. If you take anything else, check it against the full list below.

Major 9 Moderate 86 Minor 40 No known interaction 2,695 (incl. Linagliptin, Metformin Hydrochloride)
Taking anything else?

Check Another of Your Medications Against Brewer's Yeast

Covers the 2,830 medications we’ve checked against Brewer's Yeast. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Linagliptin, Metformin Hydrochloride

This page covers Brewer's Yeast only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Linagliptin, Metformin Hydrochloride page lists 285 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), St. John's Wort (major), Acai (moderate) and Adrafinil (moderate).

By severity: 3 major · 242 moderate · 40 minor.

From our pharmacist’s overview on the Linagliptin, Metformin Hydrochloride page

“Someone taking Jentadueto XR (linagliptin and metformin) for type 2 diabetes is often the same person eyeing fenugreek, bitter melon, or gymnema, and that overlap is why this page deserves real caution. Of its 285 ingredients, 239 can lower blood sugar on their own, so stacking them on a drug already doing that job risks pushing glucos…”

Reviewed by 2 · Jul 18, 2026

Open the Linagliptin, Metformin Hydrochloride interaction page

One more smart check

Taking Brewer's Yeast as Part of a Dietary Supplement Product? Check It for Interactions

We hold 126 real supplement products containing Brewer's Yeast, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Brewer's Yeast. Your product may carry other ingredients that interact with Linagliptin, Metformin Hydrochloride too, on top of Brewer's Yeast — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Brewer's Yeast and Linagliptin, Metformin Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Brewer's Yeast
Top half

#450 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Linagliptin, Metformin Hydrochloride
Top 10%

#229 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Brewer's Yeast

What is Brewer's Yeast?

Brewer's Yeast
  • Source of B vitamins
  • Diarrhea (certain types)
  • Cold and flu support
  • Digestive health
  • Acne and skin health
  • Blood sugar support

Brewer's yeast is a nutrient-rich fungus that provides B vitamins, protein, and minerals, and a related yeast product (S. boulardii) is used for some types of diarrhea. Most other health claims have limited or weak evidence. It is generally well tolerated as a food or supplement, but talk to your pharmacist or doctor before using it regularly, especially if you have a weakened immune system.

Read the full Brewer's Yeast monograph & all interactions
Keep checking

Other Drugs & Brewer's Yeast

Browse every other medication we’ve checked against Brewer's Yeast — both the ones with a known interaction and the ones without. Select any drug for the full detail.

9Major
86Moderate
40Minor
2,694No known interaction
9 Major 86 Moderate 40 Minor 2,694 No interaction
Major

9 interactions

Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Brewer's Yeast page.

Minor

40 interactions

No interaction 2,694 drugs checked — show the list

We also checked Brewer's Yeast against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,694 medications checked with no known interaction — see the full Brewer's Yeast list.

See the full Brewer's Yeast interactions page
See every supplement checked against Linagliptin, Metformin Hydrochloride, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Brewer's Yeast monograph › Uses, safety, and every drug interaction in one place Linagliptin, Metformin Hydrochloride supplement interactions › Every supplement checked against Linagliptin, Metformin Hydrochloride, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Brewer's Yeast and Linagliptin, Metformin Hydrochloride Together: Common Questions

Can you take Brewer's Yeast with Linagliptin, Metformin Hydrochloride?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Brewer's Yeast and Linagliptin, Metformin Hydrochloride interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Linagliptin, Metformin Hydrochloride and Brewer's Yeast?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.