Combretum Micranthum - Jentadueto XR (Linagliptin, Metformin Hydrochloride) Interaction
Herbal: Combretum Micranthum
Also Known As: Antidote à l'Opium, Antidote d'Opium, Antídoto de Opio, Combretum, Geza, Jungle Weed, Kinkeliba, Kinkéliba, Long-Life Herbal Tea, Opium Antidote, Plant to Heal
Drug: Linagliptin, Metformin Hydrochloride
Brand names:
Jentadueto XR

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Linagliptin, Metformin Hydrochloride is classified as belonging to the following category: Antidiabetes Drugs
Theoretically, taking Combretum micranthum leaf with antidiabetes drugs might increase the risk of hypoglycemia.
Some preliminary human and animal research suggests that Combretum micranthum leaf has hypoglycemic effects.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Kpemissi M, Potârniche AV, Lawson-Evi P, et al. Nephroprotective effect of Combretum micranthum G. Don in nicotinamide-streptozotocin induced diabetic nephropathy in rats: In-vivo and in-silico experiments. J Ethnopharmacol 2020;261:113133.
- Chika A, Bello SO. Antihyperglycaemic activity of aqueous leaf extract of Combretum micranthum (Combretaceae) in normal and alloxan-induced diabetic rats. J Ethnopharmacol 2010;129(1):34-7.
- Seck SM, Doupa D, Dia DG, et al. Clinical efficacy of African traditional medicines in hypertension: A randomized controlled trial with Combretum micranthum and Hibiscus sabdariffa. J Hum Hypertens 2017;32(1):75-81.
Combretum Micranthum Overview

Combretum Micranthum - More Interactions
Combretum Micranthum interacts with 260 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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Drug descriptions are provided by MedlinePlus.