Combretum Micranthum - Jentadueto XR (Linagliptin, Metformin Hydrochloride) Interaction
Herbal: Combretum Micranthum
Also Known As: Antidote à l'Opium, Antidote d'Opium, Antídoto de Opio, Combretum, Geza, Jungle Weed, Kinkeliba, Kinkéliba, Long-Life Herbal Tea, Opium Antidote, Plant to Heal
Drug: Linagliptin, Metformin Hydrochloride
Brand names:
Jentadueto XR
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Linagliptin, Metformin Hydrochloride is classified as belonging to the following category: Antidiabetes Drugs
Theoretically, taking Combretum micranthum leaf with antidiabetes drugs might increase the risk of hypoglycemia.
Some preliminary human and animal research suggests that Combretum micranthum leaf has hypoglycemic effects.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Kpemissi M, Potârniche AV, Lawson-Evi P, et al. Nephroprotective effect of Combretum micranthum G. Don in nicotinamide-streptozotocin induced diabetic nephropathy in rats: In-vivo and in-silico experiments. J Ethnopharmacol 2020;261:113133.
- Chika A, Bello SO. Antihyperglycaemic activity of aqueous leaf extract of Combretum micranthum (Combretaceae) in normal and alloxan-induced diabetic rats. J Ethnopharmacol 2010;129(1):34-7.
- Seck SM, Doupa D, Dia DG, et al. Clinical efficacy of African traditional medicines in hypertension: A randomized controlled trial with Combretum micranthum and Hibiscus sabdariffa. J Hum Hypertens 2017;32(1):75-81.
Combretum Micranthum Overview
Combretum micranthum, also known as bushwillow or small-flowered combretum, is a species of flowering plant that belongs to the family Combretaceae. It is native to sub-Saharan Africa, where it is widely distributed in a variety of habitats.
Combretum micranthum is purported to have a number of medicinal properties and has been used traditionally to treat a wide range of ailments. It is believed to have astringent, antibacterial, and anti-inflammatory properties, and it is used to treat a variety of conditions, including digestive disorders, respiratory conditions, and skin problems. The plant is also used as a natural remedy for fever, headache, and other ailments..
Combretum Micranthum - More Interactions
Combretum Micranthum interacts with 260 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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