Herb & supplement monograph

Marsh Marigold Drug Interactions, Uses, Safety & More

Check Marsh Marigold against your medication

Add one medication
Marsh Marigold
+
Start typing any prescription or over-the-counter drug name.
Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Marsh Marigold

0 medications have a known interaction with Marsh Marigold, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Marsh Marigold. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Marsh Marigold combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Marsh Marigold: Uses, Safety & Side Effects

The bottom line

Marsh Marigold is a wetland plant in the buttercup family that has been used in traditional and homeopathic medicine, but there is essentially no reliable human evidence that it works for any condition. The raw plant contains irritant compounds and is considered toxic when eaten fresh, so it is generally not recommended as a supplement.

Scientific name
Caltha palustris
Family
Ranunculaceae
Part used
Flowers, leaves, and roots (mainly in folk medicine)
Common forms
Tinctures, homeopathic preparations, dried herb; rarely used today
People commonly use it for
  • Skin conditions and warts
  • Cough and bronchitis (folk use)
  • Painful or irregular menstruation (folk use)
  • Constipation (folk use)
  • Joint and rheumatic complaints (folk use)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

The fresh plant is toxic and irritating; only well-prepared or homeopathic forms are used, and evidence is very limited.

PregnancyLikely Unsafe

When the fresh above ground parts are used orally or topically. There is insufficient reliable information available about the safety of the dried abo...

Read the full pregnancy detail
BreastfeedingLikely Unsafe

When the fresh above ground parts are used orally or topically. There is insufficient reliable information available about the safety of the dried abo...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Marsh Marigold (Caltha palustris) is a low-growing perennial plant in the buttercup family (Ranunculaceae). It has glossy green leaves and bright yellow, cup-shaped flowers, and it grows in wet places like marshes, ditches, and stream banks across Europe, Asia, and North America.

Despite its cheerful appearance, the fresh plant is irritating and considered poisonous if eaten raw. In traditional folk medicine and homeopathy, small or specially prepared amounts have been used for skin problems, coughs, and other complaints. It is rarely sold as a modern dietary supplement, and you are most likely to encounter it as a homeopathic remedy or tincture.

Uses & effectiveness

People have traditionally used Marsh Marigold for skin conditions such as warts, for coughs and chest complaints, for menstrual problems, and as a mild laxative. In homeopathy it has been used for certain skin eruptions.

The scientific evidence is very weak. There are no good-quality human studies showing that Marsh Marigold treats any of these conditions. Most information comes from historical folk use and a small amount of laboratory research. Because of this, it should not be relied on to treat or cure any health problem.

How it works

Like other plants in the buttercup family, Marsh Marigold contains protoanemonin, an irritant compound formed when the fresh plant is crushed. Protoanemonin can irritate the skin, mouth, and digestive tract, which is why the raw plant is considered toxic. Drying or heating the plant changes this compound into a less harmful form.

The plant also contains flavonoids, saponins, and other plant chemicals that have been studied mostly in the laboratory. Any proposed effects are based on test-tube or animal research, not on reliable studies in people, so the way it might work in the body is not well understood.

Safety & precautions

The fresh plant is toxic and can irritate the skin and mucous membranes on contact. Eating the raw plant can cause burning of the mouth, stomach upset, vomiting, and diarrhea. For this reason, it is not considered a safe food or casual herbal remedy.

People with sensitive skin or known allergies to plants in the buttercup family should be especially careful. Children and pets should be kept away from the raw plant. Because reliable safety data are lacking, pregnant and breastfeeding people should avoid Marsh Marigold entirely. Always talk with a pharmacist or doctor before using any product containing this plant.

Side effects

Contact with the fresh plant juice can cause skin redness, burning, and blistering. Taking the raw or improperly prepared plant by mouth can cause mouth and throat irritation, nausea, vomiting, abdominal pain, and diarrhea.

In larger amounts, the irritant compounds in buttercup-family plants can be more seriously harmful. If you experience severe burning, persistent vomiting, or signs of an allergic reaction, stop use and seek medical care.

Marsh Marigold: Reported Adverse Effects

Documented safety reports on Marsh Marigold from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, ingestion of marsh marigold can cause severe irritation of the gastrointestinal tract with colic and diarrhea. Irritation of the urinary tract can also occur.

Topically, skin contact with the fresh plant can cause blisters and burns that are difficult to heal.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Reports by condition
Burns Dermatologic

Topically, skin contact with the fresh marsh marigold plant can cause blisters and burns that are difficult to heal.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Diarrhea Gastrointestinal

Orally, ingestion of marsh marigold can cause severe irritation of the gastrointestinal tract with colic and diarrhea. Irritation of the urinary tract can also occur.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established or standardized dose for Marsh Marigold, and no recognized safe amount for everyday use. Because the raw plant is toxic, it should not be self-prepared or eaten.

If you choose to use a commercial tincture or homeopathic product, follow the directions on the label exactly and check with a pharmacist first. When in doubt, it is safest not to use this plant at all.

Pregnancy & Breastfeeding

Marsh Marigold & Pregnancy

Likely Unsafe

When the fresh above ground parts are used orally or topically. There is insufficient reliable information available about the safety of the dried above ground parts during pregnancy and lactation.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Marsh Marigold & Breastfeeding

Likely Unsafe

When the fresh above ground parts are used orally or topically. There is insufficient reliable information available about the safety of the dried above ground parts during pregnancy and lactation.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 references that drive our Marsh Marigold monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Marsh Marigold: Common Questions

Does Marsh Marigold interact with prescription medications?
We do not currently list any known drug interactions for Marsh Marigold. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Marsh Marigold interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Marsh Marigold with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Marsh Marigold interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Marsh Marigold used for?
Traditionally it has been used for skin problems like warts, for coughs, for menstrual complaints, and as a mild laxative, but there is no solid scientific proof it works for any of these.
Is Marsh Marigold safe to eat?
No. The fresh plant is considered toxic and irritating, and eating it raw can cause burning of the mouth, stomach upset, and vomiting.
Can I use Marsh Marigold during pregnancy or while breastfeeding?
No. Because the plant can be toxic and there is no good safety data, it should be avoided during pregnancy and breastfeeding.
Why does handling the plant sometimes irritate the skin?
When the fresh plant is crushed it releases protoanemonin, an irritant compound that can cause skin redness, burning, or blistering on contact.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Have a question about Marsh Marigold?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist