Marsh Marigold Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Marsh Marigold interacts with medications. The heart of this page is the interaction list — every drug Marsh Marigold is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Marsh Marigold is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Marsh Marigold against your medication
Add one medicationDrugs that interact with Marsh Marigold
0 medications have a known interaction with Marsh Marigold, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Marsh Marigold. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Marsh Marigold combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Marsh Marigold: Uses, Safety & Side Effects
Marsh Marigold is a wetland plant in the buttercup family that has been used in traditional and homeopathic medicine, but there is essentially no reliable human evidence that it works for any condition. The raw plant contains irritant compounds and is considered toxic when eaten fresh, so it is generally not recommended as a supplement.
- Scientific name
- Caltha palustris
- Family
- Ranunculaceae
- Part used
- Flowers, leaves, and roots (mainly in folk medicine)
- Common forms
- Tinctures, homeopathic preparations, dried herb; rarely used today
- Skin conditions and warts
- Cough and bronchitis (folk use)
- Painful or irregular menstruation (folk use)
- Constipation (folk use)
- Joint and rheumatic complaints (folk use)
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
The fresh plant is toxic and irritating; only well-prepared or homeopathic forms are used, and evidence is very limited.
When the fresh above ground parts are used orally or topically. There is insufficient reliable information available about the safety of the dried abo...
Read the full pregnancy detailWhen the fresh above ground parts are used orally or topically. There is insufficient reliable information available about the safety of the dried abo...
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Marsh Marigold (Caltha palustris) is a low-growing perennial plant in the buttercup family (Ranunculaceae). It has glossy green leaves and bright yellow, cup-shaped flowers, and it grows in wet places like marshes, ditches, and stream banks across Europe, Asia, and North America.
Despite its cheerful appearance, the fresh plant is irritating and considered poisonous if eaten raw. In traditional folk medicine and homeopathy, small or specially prepared amounts have been used for skin problems, coughs, and other complaints. It is rarely sold as a modern dietary supplement, and you are most likely to encounter it as a homeopathic remedy or tincture.
Uses & effectiveness
People have traditionally used Marsh Marigold for skin conditions such as warts, for coughs and chest complaints, for menstrual problems, and as a mild laxative. In homeopathy it has been used for certain skin eruptions.
The scientific evidence is very weak. There are no good-quality human studies showing that Marsh Marigold treats any of these conditions. Most information comes from historical folk use and a small amount of laboratory research. Because of this, it should not be relied on to treat or cure any health problem.
How it works
Like other plants in the buttercup family, Marsh Marigold contains protoanemonin, an irritant compound formed when the fresh plant is crushed. Protoanemonin can irritate the skin, mouth, and digestive tract, which is why the raw plant is considered toxic. Drying or heating the plant changes this compound into a less harmful form.
The plant also contains flavonoids, saponins, and other plant chemicals that have been studied mostly in the laboratory. Any proposed effects are based on test-tube or animal research, not on reliable studies in people, so the way it might work in the body is not well understood.
Safety & precautions
The fresh plant is toxic and can irritate the skin and mucous membranes on contact. Eating the raw plant can cause burning of the mouth, stomach upset, vomiting, and diarrhea. For this reason, it is not considered a safe food or casual herbal remedy.
People with sensitive skin or known allergies to plants in the buttercup family should be especially careful. Children and pets should be kept away from the raw plant. Because reliable safety data are lacking, pregnant and breastfeeding people should avoid Marsh Marigold entirely. Always talk with a pharmacist or doctor before using any product containing this plant.
Side effects
Contact with the fresh plant juice can cause skin redness, burning, and blistering. Taking the raw or improperly prepared plant by mouth can cause mouth and throat irritation, nausea, vomiting, abdominal pain, and diarrhea.
In larger amounts, the irritant compounds in buttercup-family plants can be more seriously harmful. If you experience severe burning, persistent vomiting, or signs of an allergic reaction, stop use and seek medical care.
Marsh Marigold: Reported Adverse Effects
Documented safety reports on Marsh Marigold from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, ingestion of marsh marigold can cause severe irritation of the gastrointestinal tract with colic and diarrhea. Irritation of the urinary tract can also occur.
Topically, skin contact with the fresh plant can cause blisters and burns that are difficult to heal.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Burns Dermatologic
Topically, skin contact with the fresh marsh marigold plant can cause blisters and burns that are difficult to heal.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Diarrhea Gastrointestinal
Orally, ingestion of marsh marigold can cause severe irritation of the gastrointestinal tract with colic and diarrhea. Irritation of the urinary tract can also occur.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no established or standardized dose for Marsh Marigold, and no recognized safe amount for everyday use. Because the raw plant is toxic, it should not be self-prepared or eaten.
If you choose to use a commercial tincture or homeopathic product, follow the directions on the label exactly and check with a pharmacist first. When in doubt, it is safest not to use this plant at all.
Marsh Marigold & Pregnancy
Marsh Marigold & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 1 references that drive our Marsh Marigold monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Marsh Marigold: Common Questions
Does Marsh Marigold interact with prescription medications?
How are Marsh Marigold interactions rated?
Is it safe to take Marsh Marigold with my medications?
Where does this Marsh Marigold interaction information come from?
What is Marsh Marigold used for?
Is Marsh Marigold safe to eat?
Can I use Marsh Marigold during pregnancy or while breastfeeding?
Why does handling the plant sometimes irritate the skin?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Have a question about Marsh Marigold?
Our pharmacists answer your medication & supplement questions — free.