Drug & supplement interaction

Combretum Micranthum + Spironolactone

Spironolactone brand names: Aldactone, Spiroton, Carospir.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Spironolactone falls into 2 drug categories that Combretum Micranthum can interact with; the most serious is rated moderate. Theoretically, taking Combretum micranthum leaf with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Combretum Micranthum and Spironolactone

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Combretum Micranthum interacts with whole categories of medication. Spironolactone falls into 2 of those categories, so it can interact with Combretum Micranthum in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTIHYPERTENSIVE DRUGS

1 of 2

Why this applies to Spironolactone

Spironolactone falls under ANTIHYPERTENSIVE DRUGS — the group Combretum Micranthum interacts with.

Theoretically, taking Combretum micranthum leaf with antihypertensive drugs might increase the risk of hypotension.
Clinical research suggests that Combretum micranthum leaf reduces blood pressure.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: kinkeliba tea (Combretum micranthum) seems to gently lower blood pressure on its own. Spironolactone is already working to bring your pressure and fluid down, so stacking the two could push your blood pressure a little lower than you'd want. That can leave you feeling dizzy, lightheaded, or tired, especially when you stand up quickly.

The evidence here is on the softer side and mostly theoretical, so I don't want you to panic. There's also a separate point worth mentioning: spironolactone holds onto potassium, and some herbal products can affect potassium too, so it's smart to keep an eye on that. Before adding this tea, check in with your pharmacist or doctor, and let them know if you notice dizziness or fatigue.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Bourqui A, Niang EAB, Graz B, et al. Hypertension treatment with Combretum micranthum or Hibiscus sabdariffa, as decoction or tablet: a randomized clinical trial. J Hum Hypertens 2020. PubMed
  2. Seck SM, Doupa D, Dia DG, et al. Clinical efficacy of African traditional medicines in hypertension: A randomized controlled trial with Combretum micranthum and Hibiscus sabdariffa. J Hum Hypertens 2017;32(1):75-81. PubMed
Moderate

DIURETIC DRUGS

2 of 2

Spironolactone also falls under DIURETIC DRUGS.

Theoretically, taking Combretum micranthum leaf with diuretic drugs might increase the risk of hyponatremia.
Combretum micranthum leaf has shown natriuretic effects in preliminary clinical research.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: kinkeliba tea may act a little like a water pill itself, helping your body flush out sodium. Spironolactone (Aldactone) already does that job, so drinking the tea on top of it could push your sodium too low. We call low sodium hyponatremia, and it can leave you feeling dizzy, tired, headachy, nauseous, or even confused if it drops far enough.

Now, the honest part: this is mostly theoretical, based on early, lower quality research showing the leaf increases urine sodium. It's not a strong red flag, but since spironolactone also affects your salt and potassium balance, it's worth a quick chat with your pharmacist or doctor before pairing the two, especially if you already get your electrolytes checked.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Seck SM, Doupa D, Dia DG, et al. Clinical efficacy of African traditional medicines in hypertension: A randomized controlled trial with Combretum micranthum and Hibiscus sabdariffa. J Hum Hypertens 2017;32(1):75-81. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Combretum Micranthum Also Interacts With Other Medications

Combretum Micranthum has 264 moderate known drug interactions in our database — the Spironolactone one above is among them. If you take anything else, check it against the full list below.

Moderate 264 No known interaction 2,566 (incl. Spironolactone)
Taking anything else?

Check Another of Your Medications Against Combretum Micranthum

Covers the 2,830 medications we’ve checked against Combretum Micranthum. Pick one to open its full report.

From our Q&A

Questions About Combretum Micranthum or Spironolactone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Combretum Micranthum or Spironolactone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Spironolactone

This page covers Combretum Micranthum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Spironolactone page lists 206 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Lithium (major) and Oleander (major).

By severity: 7 major · 174 moderate · 25 minor.

From our pharmacist’s overview on the Spironolactone page

“Potassium is the supplement I check first for anyone on spironolactone (Aldactone, Carospir), because this water pill works by holding potassium in the body, and supplementing more on top of that can push blood levels too high. It is one of 206 supplement and herbal ingredients with documented interactions here, and the list warrants g…”

Reviewed by 2 · Jul 18, 2026

Open the Spironolactone interaction page

How much people look this up

Where Combretum Micranthum and Spironolactone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Combretum Micranthum
Steady interest

#1,449 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Spironolactone
Top 10%

#278 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Combretum Micranthum

What is Combretum Micranthum?

Combretum Micranthum
  • Digestive upset
  • Liver and gallbladder support
  • Fever
  • Weight management
  • Mild urinary or fluid retention
  • Traditional opium withdrawal aid

Combretum micranthum (kinkeliba) is a West African shrub whose leaves are brewed into a traditional tea for digestion, liver complaints, and fever. Solid human studies are lacking, so its benefits remain unproven, and people who are pregnant, breastfeeding, or have liver or kidney problems should be cautious and talk to a healthcare professional first.

Read the full Combretum Micranthum monograph & all interactions
Medication

About Spironolactone

What Is Spironolactone Used For?

Brand names: Aldactone, Spiroton, Carospir

Spironolactone tablets (including Aldactone) are used to treat moderate-to-severe heart failure, high blood pressure, and fluid retention (edema) caused by liver cirrhosis or nephrotic syndrome. They are also used to diagnose and manage primary hyperaldosteronism — a condition where the adrenal glands produce too much of the hormone aldosterone.

Spironolactone oral suspension shares several of these uses — heart failure, high blood pressure, and edema from liver cirrhosis — but is not the same as Aldactone and is not therapeutically interchangeable with it. Your prescriber will choose the right form for your situation.

See full Spironolactone drug information
Keep checking

Other Drugs & Combretum Micranthum

Browse every other medication we’ve checked against Combretum Micranthum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
264Moderate
0Minor
2,565No known interaction
264 Moderate 2,565 No interaction
Moderate

264 interactions

Showing 60 of 264 moderate interactions — see all 264 on the Combretum Micranthum page.

No interaction 2,565 drugs checked — show the list

We also checked Combretum Micranthum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,565 medications checked with no known interaction — see the full Combretum Micranthum list.

See the full Combretum Micranthum interactions page
See every supplement checked against Spironolactone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Combretum Micranthum monograph › Uses, safety, and every drug interaction in one place Spironolactone supplement interactions › Every supplement checked against Spironolactone, ranked by severity Spironolactone drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Combretum Micranthum and Spironolactone Together: Common Questions

Can you take Combretum Micranthum with Spironolactone?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Combretum Micranthum and Spironolactone?
Spironolactone belongs to more than one drug category, and Combretum Micranthum interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Combretum Micranthum and Spironolactone interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.