Interaction Question: Omeprazole, Spironolactone And Phentermine

In our latest question and answer, the pharmacist discusses a reader's concern about drug interactions.


Can I take omeprazole and spironolactone in the early morning, around 7:00a, followed by phentermine at 9:00a, and then Cellcore supplements at 11:00a?

Asked by TDC On Mar 17, 2024

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Mar 20, 2024
Last updated Apr 12, 2024


Thank you for your question! I'm glad to help.

There is no known interaction between phentermine, spironolactone, and omeprazole. However, there are a few important things to consider:

  • Omeprazole has specific administration instructions for optimal effects.
  • Phentermine and spironolactone may have opposing actions on blood pressure.


First and foremost, it is important to take omeprazole correctly to get the best effects from it.

Generally, it should be taken 30-60 minutes before a meal and other medications. This allows it to get into your system and inhibit the proton pumps before food or other medications enter your system.

Secondly, I don't know why you are taking spironolactone, but if it is for blood pressure, it is important to note that phentermine, being a stimulant and similar to amphetamines, can increase blood pressure. Amphetamines are known to cause modest increases in average blood pressure (BP) and heart rate (HR).

For example, one review of amphetamines in adults noted that amphetamines increased systolic blood pressure (the top number on a blood pressure reading) by 8.4 mm Hg and diastolic blood pressure (the lower number) by 4.9 mm Hg. Additionally, the study found that heart rate increased an average of 10.6 beats per minute.

If you are taking spironolactone for something else, like acne, this opposing effect on blood pressure likely isn't a clinically significant concern for you.

I looked up 'Cellcore' supplements and it looks like there are quite a few available. I am unsure of which you are referring to, so feel free to submit another question with specifics. Additionally, you can take a look at the ingredients in these supplements and look them up individually on our interaction checker (Drug-Herb Interactions).

Final Words

Thanks again for reaching out, and please feel free to do so again anytime!


  • Interaction Question: Omeprazole, Spironolactone And Phentermine, PubMed
  • An open-label study of the tolerability of mixed amphetamine salts in adults with attention-deficit/hyperactivity disorder and treated primary essential hypertension, PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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