Interaction Question: Omeprazole, Spironolactone And Phentermine
In our latest question and answer, the pharmacist discusses a reader's concern about drug interactions.
Can I take omeprazole and spironolactone in the early morning, around 7:00a, followed by phentermine at 9:00a, and then Cellcore supplements at 11:00a?
Mar 17, 2024- There is no known interaction between phentermine, spironolactone, and omeprazole.
- Omeprazole should be taken 30-60 minutes before meals and other medications for best effectiveness.
- Phentermine can increase blood pressure and heart rate, which may work against spironolactone if it is being used to lower blood pressure.
Answer
Thank you for your question! I'm glad to help.
There is no known interaction between phentermine, spironolactone, and omeprazole. However, there are a few important things to consider:
- Omeprazole has specific administration instructions for optimal effects.
- Phentermine and spironolactone may have opposing actions on blood pressure.
Details
First and foremost, it is important to take omeprazole correctly to get the best effects from it.
Generally, it should be taken 30-60 minutes before a meal and other medications. This allows it to get into your system and inhibit the proton pumps before food or other medications enter your system.
Secondly, I don't know why you are taking spironolactone, but if it is for blood pressure, it is important to note that phentermine, being a stimulant and similar to amphetamines, can increase blood pressure. Amphetamines are known to cause modest increases in average blood pressure (BP) and heart rate (HR).
For example, one review of amphetamines in adults noted that amphetamines increased systolic blood pressure (the top number on a blood pressure reading) by 8.4 mm Hg and diastolic blood pressure (the lower number) by 4.9 mm Hg. Additionally, the study found that heart rate increased an average of 10.6 beats per minute.
If you are taking spironolactone for something else, like acne, this opposing effect on blood pressure likely isn't a clinically significant concern for you.
I looked up 'Cellcore' supplements and it looks like there are quite a few available. I am unsure of which you are referring to, so feel free to submit another question with specifics. Additionally, you can take a look at the ingredients in these supplements and look them up individually on our interaction checker (Drug-Herb Interactions).
Final Words
Thanks again for reaching out, and please feel free to do so again anytime!
References & sources
Glossary — Terms in This Answer
- Proton pumps
- Proteins in the stomach that produce acid, which omeprazole blocks to reduce stomach acid.
- Stimulant
- A substance that increases activity in the brain and body, causing effects like increased heart rate and alertness.
- Amphetamines
- A class of powerful stimulant drugs that increase energy and alertness but can raise blood pressure and heart rate.
- Systolic blood pressure
- The higher number in a blood pressure reading, which measures pressure in your arteries when your heart beats.
- Diastolic blood pressure
- The lower number in a blood pressure reading, which measures pressure in your arteries when your heart is resting between beats.
- Heart rate
- The number of times your heart beats per minute.
- Clinically significant
- Important enough to have a meaningful effect on a person's health or treatment.
Dr. Brian Staiger, PharmD
Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified
Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...
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