How Long To Separate Benadryl And Dramamine

In our latest question and answer, the pharmacist discusses how long you should separate doses of Benadryl and Dramamine.


Can you take Benadryl and Dramamine in one day at separate times? About 4-6 hours apart? Thank you!

Asked by Ryan On Mar 15, 2024

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Mar 17, 2024
Last updated Apr 07, 2024

Key points

  • In general, doses of Benadryl and Dramamine should be separated by at least four to six hours.


Thank you for reaching out, and I appreciate your question.

Benadryl (diphenhydramine) and Dramamine (dimenhydrinate) are very similar drugs based on the fact that Dramamine (dimenhydrinate) is the chlorotheophylline salt of Benadryl (diphenhydramine).

The active moiety in Dramamine (dimenhydrinate) is Benadryl (diphenhydramine). In fact, Dramamine (dimenhydrinate) contains about 55% Benadryl (diphenhydramine), and about 45% 8-chlorotheophylline. 8-chlorotheophylline has mild stimulating properties, which is why Dramamine tends to cause a little less drowsiness compared to Benadryl.

I answered a similar question to yours about two years ago and dove deep into how the two drugs compare. You can find more information here.

How Long To Separate The Drugs

I want to point out a couple of assumptions I'm making here. Firstly, that you are an adult, and secondly, that you are referring to the original Dramamine, not Dramamine Less Drowsy, which contains a different active ingredient (meclizine).

The duration of action of both Benadryl and Dramamine is essentially the same, about 4-6 hours per dose.

Therefore, yes, you can take both Benadryl and Dramamine the same day, and you should separate doses of each by at least 4 to 6 hours. Doing so will be your best bet to avoid having both drugs affect you at the same time and increase the risk of side effects (like dizziness, sedation, etc.).

Final Words

I hope this answer provided the information you were looking for! Feel free to reach out if there is anything else I can help with.


  • Dimenhydrinate Monograph, PubChem
  • Diphenhydramine Monograph, PubChem

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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