Drug & supplement interaction

Rupturewort + Glyburide, Metformin

Glyburide, Metformin brand name: Glucovance.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Rupturewort and Glyburide, Metformin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Glyburide, Metformin states a food rule worth keeping to.

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Interaction report

Rupturewort and Glyburide, Metformin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Glyburide, Metformin and Rupturewort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rupturewort safety at a glance

Rupturewort overall Use caution Limited safety data exist, so use carefully and under professional guidance.
Pregnancy Avoid Not enough safety information; traditional diuretic use makes it best avoided in pregnancy.
Breastfeeding Avoid No reliable safety data, so it is best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Glyburide, Metformin and Rupturewort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Glyburide, Metformin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Glyburide, Metformin is filed under 10 classifications — including sulfonylureas, organic cation transporter 2 (oct2) substrates, organic anion-transporting polypeptide substrates (oatp). Rupturewort has documented interactions with 1 drug class — the most serious being lithium (moderate) — and none of Glyburide, Metformin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Rupturewort Does Interact With Other Medications

Rupturewort has 1 moderate known drug interaction in our database — Glyburide, Metformin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 No known interaction 2,829 (incl. Glyburide, Metformin)
Taking anything else?

Check Another of Your Medications Against Rupturewort

Covers the 2,830 medications we’ve checked against Rupturewort. Pick one to open its full report.

What to actually watch for

What Glyburide, Metformin’s Own FDA Label Lists

This is not an interaction — none of it involves Rupturewort. These are the most notable effects listed in the ADVERSE REACTIONS section of Glyburide, Metformin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Low blood sugar Worth acting on
  • A higher chance of infection Worth acting on
  • Weight gain
  • Tremor or shakiness
  • Sweating
  • Swelling
  • Stomach pain
  • Dizziness
  • Diarrhea
  • Vomiting

Showing the 10 most notable of 12 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Glyburide, Metformin. Read the label on DailyMed › Rupturewort’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Rupturewort side to compare — that is a limit of the record, not a statement that Rupturewort has no side effects.

How to take them

Some Glyburide, Metformin Products Have a Food Rule — Rupturewort Should Not Break It

At least one FDA label for a product containing Glyburide, Metformin says to take it with food. If you take Rupturewort on an empty stomach out of habit, keep them separate — and take Glyburide, Metformin with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Glyburide, Metformin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

For patients with type 2 diabetes whose hyperglycemia cannot be satisfactorily managed with diet and exercise alone, the recommended starting dose is 1.25 mg glyburide and 250 mg metformin hydrochloride once a day with a meal.

From the Dosage and Administration section of the FDA label we read for Glyburide, Metformin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Glyburide, Metformin

This page covers Rupturewort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glyburide, Metformin page lists 332 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Beer (major), Grapefruit (major) and Siberian Cocklebur (major).

By severity: 7 major · 281 moderate · 44 minor.

From our pharmacist’s overview on the Glyburide, Metformin page

“Glucovance combines glyburide and metformin to lower blood sugar, and its list of 332 interacting supplements deserves real care, starting with the seven rated major. Most entries, 239 of them, lower blood sugar on their own, so stacking one on top of a drug built to do exactly that can drop your glucose into dangerous territory.”

Reviewed by 2 · Jul 18, 2026

Open the Glyburide, Metformin interaction page

One more smart check

Taking Rupturewort as Part of a Dietary Supplement Product? Check It for Interactions

We hold 19 real supplement products containing Rupturewort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rupturewort. Even though Rupturewort itself has no known interaction with Glyburide, Metformin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Rupturewort and Glyburide, Metformin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rupturewort
Steady interest

#915 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glyburide, Metformin
Top half

#980 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rupturewort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Rupturewort and Glyburide, Metformin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rupturewort

What is Rupturewort?

  • Urinary tract complaints
  • Mild fluid retention (as a diuretic)
  • Kidney and bladder support
  • Wound healing and inflammation (topical, traditional)
  • Spasms or cramping (traditional)

Rupturewort is a traditional European herb mainly used as a mild diuretic and for urinary complaints. Solid human research is very limited, so its true benefits and long-term safety are not well established. Talk to a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Herniaria glabra · Caryophyllaceae · Aerial parts (the above-ground flowering herb) · Tea, dried herb, tincture, capsules

An interaction check asks whether these two react with each other — it does not ask whether Rupturewort is a good idea for someone in your situation. Here is what our Rupturewort record says about it on its own.

Rupturewort: dosing

There is no well-established or standardized dose for rupturewort. Traditional use involves brewing the dried herb as a tea, but reliable dosing guidance from clinical research does not exist.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Rupturewort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rupturewort monograph & all interactions
Keep checking

Other Drugs & Rupturewort

Browse every other medication we’ve checked against Rupturewort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
0Minor
2,828No known interaction
1 Moderate 2,828 No interaction
Moderate

1 interaction

No interaction 2,828 drugs checked — show the list

We also checked Rupturewort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Rupturewort list.

See the full Rupturewort interactions page
See every supplement checked against Glyburide, Metformin, ranked by severity
Evidence & sources

Rupturewort References

The 1 references that drive our Rupturewort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hakim EM, Sivak KV, Kaukhova IE. Evaluation of the diuretic effect of crude ethanol and saponin-rich extracts of Herniaria glabra L. in rats. J Ethnopharmacol. 2021 Jun 12;273:113942. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rupturewort and Glyburide, Metformin Together: Common Questions

Is it safe to take Rupturewort with Glyburide, Metformin?
We do not list a known interaction between Rupturewort and Glyburide, Metformin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Rupturewort and Glyburide, Metformin at the same time of day?
At least one FDA label for a product containing Glyburide, Metformin says to take it with food. If you take Rupturewort on an empty stomach out of habit, keep them separate and take Glyburide, Metformin with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Glyburide, Metformin products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Rupturewort and Glyburide, Metformin combination checked?
Interactions in our licensed database are recorded against drug classes. Glyburide, Metformin is filed under 10 classifications, and Rupturewort has documented interactions with 1 drug class — none of Glyburide, Metformin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Rupturewort interact with any other medications?
Yes. Rupturewort has 1 documented drug interaction in our database — Glyburide, Metformin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Glyburide, Metformin interact with any supplements?
Yes. Glyburide, Metformin has documented interactions with 332 supplements in our database — Rupturewort is not one of them. The Glyburide, Metformin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rupturewort monograph Uses, safety profile, and every drug interaction in one place Glyburide, Metformin supplement interactions Every supplement checked against Glyburide, Metformin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Glyburide, Metformin and Rupturewort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.