Drug & supplement interaction

Rupturewort + Medroxyprogesterone Acetate

Medroxyprogesterone Acetate brand names: Proclim, Cycrin, Curretab, Depo-Provera CI.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Rupturewort and Medroxyprogesterone Acetate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Rupturewort and Medroxyprogesterone Acetate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Medroxyprogesterone Acetate and Rupturewort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rupturewort safety at a glance

Rupturewort overall Use caution Limited safety data exist, so use carefully and under professional guidance.
Pregnancy Avoid Not enough safety information; traditional diuretic use makes it best avoided in pregnancy.
Breastfeeding Avoid No reliable safety data, so it is best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Medroxyprogesterone Acetate and Rupturewort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Medroxyprogesterone Acetate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Medroxyprogesterone Acetate is filed under 3 classifications — progestin, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Rupturewort has documented interactions with 1 drug class — the most serious being lithium (moderate) — and none of Medroxyprogesterone Acetate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Rupturewort Does Interact With Other Medications

Rupturewort has 1 moderate known drug interaction in our database — Medroxyprogesterone Acetate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 No known interaction 2,829 (incl. Medroxyprogesterone Acetate)
Taking anything else?

Check Another of Your Medications Against Rupturewort

Covers the 2,830 medications we’ve checked against Rupturewort. Pick one to open its full report.

What to actually watch for

What Medroxyprogesterone Acetate’s Own FDA Label Lists

This is not an interaction — none of it involves Rupturewort. These are the most notable effects listed in the ADVERSE REACTIONS section of Medroxyprogesterone Acetate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • Bone thinning Worth acting on
  • Low mood Worth acting on
  • A severe allergic reaction Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on
  • Changes to your period
  • A change in sex drive
  • Breast tenderness
  • Acne
  • Weight gain

Showing the 10 most notable of 19 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Medroxyprogesterone Acetate. Read the label on DailyMed › Where a percentage is shown, it is the share of 60,491 voluntary FDA FAERS reports for Medroxyprogesterone Acetate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Rupturewort’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Rupturewort side to compare — that is a limit of the record, not a statement that Rupturewort has no side effects.

From our Q&A

Questions About Rupturewort or Medroxyprogesterone Acetate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Rupturewort or Medroxyprogesterone Acetate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Medroxyprogesterone Acetate

This page covers Rupturewort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Medroxyprogesterone Acetate page lists 139 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

Open the Medroxyprogesterone Acetate interaction page

One more smart check

Taking Rupturewort as Part of a Dietary Supplement Product? Check It for Interactions

We hold 19 real supplement products containing Rupturewort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rupturewort. Even though Rupturewort itself has no known interaction with Medroxyprogesterone Acetate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Rupturewort and Medroxyprogesterone Acetate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rupturewort
Steady interest

#786 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Medroxyprogesterone Acetate
Steady interest

#2,322 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rupturewort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Rupturewort and Medroxyprogesterone Acetate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rupturewort

What is Rupturewort?

  • Urinary tract complaints
  • Mild fluid retention (as a diuretic)
  • Kidney and bladder support
  • Wound healing and inflammation (topical, traditional)
  • Spasms or cramping (traditional)

Rupturewort is a traditional European herb mainly used as a mild diuretic and for urinary complaints. Solid human research is very limited, so its true benefits and long-term safety are not well established. Talk to a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Herniaria glabra · Caryophyllaceae · Aerial parts (the above-ground flowering herb) · Tea, dried herb, tincture, capsules

An interaction check asks whether these two react with each other — it does not ask whether Rupturewort is a good idea for someone in your situation. Here is what our Rupturewort record says about it on its own.

Rupturewort: dosing

There is no well-established or standardized dose for rupturewort. Traditional use involves brewing the dried herb as a tea, but reliable dosing guidance from clinical research does not exist.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Rupturewort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rupturewort monograph & all interactions
Medication

About Medroxyprogesterone

What Is Medroxyprogesterone Used For?

Brand names: Proclim, Cycrin, Curretab, Depo-Provera CI

Medroxyprogesterone is a progestin (a form of the hormone progesterone). The injections and tablets are used for different things.

  • Injections (Depo-Provera CI and medroxyprogesterone acetate injectable suspension): prevent pregnancy in females of reproductive potential.
  • Depo-SubQ Provera 104 (subcutaneous): prevents pregnancy and manages endometriosis-associated pain in females of reproductive age.
  • Tablets (Provera and medroxyprogesterone acetate tablets): treat secondary amenorrhea (missed periods) and abnormal uterine bleeding due to hormonal imbalance when there is no underlying problem such as fibroids or uterine cancer. They also help prevent endometrial hyperplasia (overgrowth of the uterine lining) in postmenopausal women with a uterus who take daily oral conjugated estrogens.

The injections are not recommended for more than 2 years unless other options are considered inadequate.

See full Medroxyprogesterone drug information
Keep checking

Other Drugs & Rupturewort

Browse every other medication we’ve checked against Rupturewort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
0Minor
2,828No known interaction
1 Moderate 2,828 No interaction
Moderate

1 interaction

No interaction 2,828 drugs checked — show the list

We also checked Rupturewort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Rupturewort list.

See the full Rupturewort interactions page
See every supplement checked against Medroxyprogesterone Acetate, ranked by severity
Evidence & sources

Rupturewort References

The 1 references that drive our Rupturewort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hakim EM, Sivak KV, Kaukhova IE. Evaluation of the diuretic effect of crude ethanol and saponin-rich extracts of Herniaria glabra L. in rats. J Ethnopharmacol. 2021 Jun 12;273:113942. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rupturewort and Medroxyprogesterone Acetate Together: Common Questions

Is it safe to take Rupturewort with Medroxyprogesterone Acetate?
We do not list a known interaction between Rupturewort and Medroxyprogesterone Acetate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Rupturewort and Medroxyprogesterone Acetate combination checked?
Interactions in our licensed database are recorded against drug classes. Medroxyprogesterone Acetate is filed under 3 classifications, and Rupturewort has documented interactions with 1 drug class — none of Medroxyprogesterone Acetate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Rupturewort interact with any other medications?
Yes. Rupturewort has 1 documented drug interaction in our database — Medroxyprogesterone Acetate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Medroxyprogesterone Acetate interact with any supplements?
Yes. Medroxyprogesterone Acetate has documented interactions with 139 supplements in our database — Rupturewort is not one of them. The Medroxyprogesterone Acetate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rupturewort monograph Uses, safety profile, and every drug interaction in one place Medroxyprogesterone drug information The full plain-English guide to this medication Medroxyprogesterone Acetate supplement interactions Every supplement checked against Medroxyprogesterone Acetate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Medroxyprogesterone Acetate and Rupturewort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.