Sitagliptin

45 interactions 2 explained in plain English
Also sold as: Brynovin Januvia Januvia® Zituvio
About Sitagliptin

Sitagliptin is a DPP-4 inhibitor medication used to lower blood sugar levels in adults with type 2 diabetes. Read the full Sitagliptin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Moxifloxacin Chloroquine Octreotide Insulin Glulisine (Rdna Origin) Injection Levofloxacin Injection Ofloxacin Otic
22 Major 22 Moderate 1 Minor
All (45) Major (22) Moderate (22) Minor (1)

Moderate

Sitagliptin Lisinopril Prinivil Explained An increased risk of hypoglycemia Details Sitagliptin Atenolol Tenormin Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Acebutolol Sectral® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Benazepril Lotensin An increased risk of hypoglycemia Details Sitagliptin Betaxolol Betoptic S Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Betaxolol Ophthalmic Betoptic® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Bisoprolol Zebeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Captopril Capoten® An increased risk of hypoglycemia Details Sitagliptin Enalapril Epaned An increased risk of hypoglycemia Details Sitagliptin Esmolol Brevibloc Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Fosinopril Monopril® An increased risk of hypoglycemia Details Sitagliptin Glimepiride Amaryl An increased risk of hypoglycemia Details Sitagliptin Glipizide Glucotrol An increased risk of hypoglycemia Details Sitagliptin Labetalol Normodyne® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Levobunolol Ophthalmic AKBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Levothyroxine Ermeza Worsening of glycemic control Details Sitagliptin Moexipril Univasc® An increased risk of hypoglycemia Details Sitagliptin Nadolol Corgard Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Nateglinide Starlix® An increased risk of hypoglycemia Details Sitagliptin Nebivolol Bystolic Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Penbutolol Levatol® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Perindopril Aceon An increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.