Can You Cut Januvia Tablets In Half?

In our latest question and answer, the pharmacist discusses whether or not Januvia tablets can be cut or split in half.

Question

I am taking Januvia. I was taking 100mg but now my doctor wants to decrease my dose and start me on the 50mg. I have an entire bottle of the 100mg tablets I recently picked up. Can I just cut those in half to get a 50mg dose?

Asked by Ashley On Oct 27, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Oct 27, 2022
Last updated May 03, 2024

Answer

Januvia (sitagliptin) tablets are not recommended to be cut, split or crushed, according to the manufacturer.

Per the prescribing information for Januvia:

The recommended dose of JANUVIA is 100 mg once daily. JANUVIA can be taken with or without food. JANUVIA should be swallowed whole. The tablets must not be split, crushed, or chewed before swallowing.
Januvia Prescribing Information

Why Can't Januvia Be Split In Half?

While the manufacturer does not give a specific reason why Januvia should not be cut in half, it is important to note that the tablets are film-coated.

Typically, a film-coating on tablets makes them easier to swallow and can protect them temporarily from the contents of the stomach, improving drug stability. If a film-coated tablet is split or crushed, this coating is destroyed.

There, unfortunately, is no information or data available to know if the drug will be negatively affected if it is crushed, cut or split, so, for this reason, it is important to not do so. The tablets should be swallowed whole.

It is also important to note that since Januvia tablets are not intended to be cut or split, they do not have a score mark, as you can see in the image below:

Januvia 25 50 and 100mg tabs next to each other

Alternatives To Splitting Januvia Tablets

Januvia is available in three different strengths:

  • Januvia 25mg
  • Januvia 50mg
  • Januvia 100mg

If your doctor has switched you from the 100mg dose to the 50mg dose, be sure to get another prescription so the pharmacy can dispense the correct medication for you.

It would be prudent to hold on to the Januvia 100mg tablets until they expire, just in case you need to increase your dose in the future.

Final Words

Thanks for contacting us and please do so again in the future!

References

  • Januvia Prescribing Information, AccessFDA
  • Stability of extemporaneously prepared sitagliptin phosphate solution, PubMed
  • Pharmaceutical Application of Tablet Film Coating, PubMed
  • A Comprehensive Review on Pharmaceutical Film Coating: Past, Present, and Future, PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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