Can You Split Losartan?

In our latest question and answer, the pharmacist discusses whether or not it is safe to cut/split losartan tablets.

2 min read Updated Jun 2026 Read by 37,350 people
Can You Split Losartan?
Share
Gigi asked

Can I cut losartan potassium 25mg in half?

May 11, 2021
The quick answer
  • Losartan tablets are safe to split in half since they don't have extended-release mechanisms. You should use a tablet splitter or sharp blade to cut them evenly, as regular kitchen knives may create uneven pieces. Only split your losartan if your doctor has specifically advised you to do so.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.
Medications in this answer — tap to explore

Answer

Hi Gigi and thanks for reaching out to us. I appreciate you asking. I sometimes find out after the fact that my patients have cut medication in half, which can potentially be unsafe. It depends on the medication.

Splitting Losartan? 

Losartan is a medication usually taken once daily to treat high blood pressure. It is perfectly safe to cut your losartan tablet in half.

In general, as long as the tablet doesn’t say extended release, delayed release, or specifically not to cut them, it’s usually safe to cut these medications in half. However, exceptions do exist, so please continue to double-check for each individual medication. Losartan tablets do not have any sort of extended-release mechanism or exception and are safe to split.

However, I want to point out that I don’t believe that I have ever seen a losartan tablet that was scored (an imprint halfway through the tablet to allow it to be broken in half easier). Some manufacturers, including the brand, produce these tablets in a teardrop shape which would be extremely difficult to split evenly.

Therefore, I would recommend using a very thin and sharp blade to cut through them such as a tablet splitter or a new razor blade. If you were to use a regular knife from your kitchen, you might end up with two uneven portions and some unusable powder.  

Lastly, losartan 12.5mg is a very low dose. I have seen it once or twice throughout my career as a pharmacist, but it’s rare. While it’s safe to split the medication, this might not be an effective dose to treat your blood pressure. Please only split these if your physician advised you to cut these in half.

Final Words

I hope this helps! Feel free to write us again in the future.

References & sources
  1. Cozaar Prescribing Information — FDA
  2. Do not crush list 2020 — ISMP (subscription required)
Glossary — Terms in This Answer
Extended-release
A medication formulation designed to release the drug slowly over many hours instead of all at once.
Delayed-release
A medication formulation that is designed to release the drug at a specific location in the digestive system rather than immediately in the stomach.
Scored
A tablet that has a line or groove imprinted on it to make it easier to break into smaller pieces.
Losartan
A medication used to treat high blood pressure by relaxing blood vessels.
Tablet splitter
A small tool designed to cut tablets in half evenly and safely.
Dose
A specific amount of medication that a person takes at one time.
Did this answer your question?
Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

More answers from Brian →
Ask a Pharmacist