Can You Split Losartan?
In our latest question and answer, the pharmacist discusses whether or not it is safe to cut/split losartan tablets.

Question
Can I cut losartan potassium 25mg in half?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 16, 2025
Key points
- Losartan is a blood pressure medication. It is safe to cut in half.
- In general, unless it’s an extended-release, delayed-release, or specially coated medication, it’s usually safe to cut in half.
- Losartan tablets are not scored and some may have an odd teardrop shape. Use a very sharp and thin blade like a razor to minimize loss and ensure an even cut.
- Losartan 12.5mg is an unusually low dose. Only do this if prescribed by your physician.
Answer
Hi Gigi and thanks for reaching out to us. I appreciate you asking. I sometimes find out after the fact that my patients have cut medication in half, which can potentially be unsafe. It depends on the medication.
Splitting Losartan?
Losartan is a medication usually taken once daily to treat high blood pressure. It is perfectly safe to cut your losartan tablet in half.
In general, as long as the tablet doesn’t say extended release, delayed release, or specifically not to cut them, it’s usually safe to cut these medications in half. However, exceptions do exist, so please continue to double-check for each individual medication. Losartan tablets do not have any sort of extended-release mechanism or exception and are safe to split.
However, I want to point out that I don’t believe that I have ever seen a losartan tablet that was scored (an imprint halfway through the tablet to allow it to be broken in half easier). Some manufacturers, including the brand, produce these tablets in a teardrop shape which would be extremely difficult to split evenly.
Therefore, I would recommend using a very thin and sharp blade to cut through them such as a tablet splitter or a new razor blade. If you were to use a regular knife from your kitchen, you might end up with two uneven portions and some unusable powder.
Lastly, losartan 12.5mg is a very low dose. I have seen it once or twice throughout my career as a pharmacist, but it’s rare. While it’s safe to split the medication, this might not be an effective dose to treat your blood pressure. Please only split these if your physician advised you to cut these in half.
Final Words
I hope this helps! Feel free to write us again in the future.
References
- Cozaar Prescribing Information, FDA
- Do not crush list 2020, ISMP (subscription required)
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Dr. Brian Staiger, PharmD
- 33359 views