Idelalisib and Lovastatin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Idelalisib
Lovastatin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased lovastatin exposure and an increased risk of myopathy and rhabdomyolysis
Interaction Deep Dive
Using lovastatin with a strong CYP3A4 inhibitor such as idelalisib is contraindicated due to the potential for serious reactions such as myopathy and rhabdomyolysis. If short-term coadministration is unavoidable, lovastatin therapy should be suspended during the course of idelalisib treatment21.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated lovastatin metabolism by idelalisib
Common questions
Can I take Idelalisib and Lovastatin together?
Increased lovastatin exposure and an increased risk of myopathy and rhabdomyolysis Always confirm with your pharmacist or prescriber before making any change.
How serious is the Idelalisib and Lovastatin interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Idelalisib or Lovastatin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: ALTOPREV(R) oral extended-release tablets, lovastatin oral extended-release tablets. Covis Pharma (per FDA), King of Prussia, PA, 2024. DailyMed
- Product Information: MEVACOR(R) oral tablets, lovastatin oral tablets. Merck & Co, Inc. (Per FDA), Whitehouse Station, NJ, 2012. DailyMed
Keep reading about Idelalisib
Keep reading about Lovastatin
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
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