Idelalisib and Finerenone: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Idelalisib
Finerenone
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased finerenone exposure and an increased risk of finerenone-related adverse effects
Interaction Deep Dive
Concomitant use of finerenone, a CYP3A4 substrate, with a strong CYP3A4 inhibitor is contraindicated as it increases finerenone exposure, which may increase the risk of finerenone adverse reactions. Concomitant use of finerenone, a CYP3A4 substrate, with itraconazole, a strong CYP3A4 inhibitor, increased finerenone AUC by greater than 400%1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of finerenone
Literature reports
1 report — tap to read
a) Concomitant use of finerenone, a CYP3A4 substrate, with itraconazole, a strong CYP3A4 inhibitor, increased finerenone AUC by greater than 400% 1.
Common questions
Can I take Idelalisib and Finerenone together?
Increased finerenone exposure and an increased risk of finerenone-related adverse effects Always confirm with your pharmacist or prescriber before making any change.
How serious is the Idelalisib and Finerenone interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Idelalisib or Finerenone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: KERENDIA(R) oral tablets, finerenone oral tablets. Bayer HealthCare Pharmaceuticals Inc (per FDA), Whippany, NJ, 2025. DailyMed
Keep reading about Idelalisib
Keep reading about Finerenone
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist