Medication interaction hub

What Supplements Interact with Dihydroxyaluminum Sodium Carbonate?

Dihydroxyaluminum Sodium Carbonate brand name: Rolaids. Every interaction below applies to the brands too.

35 Interactions 1 Major 14 Moderate 20 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Dihydroxyaluminum Sodium Carbonate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Dihydroxyaluminum Sodium Carbonate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Rolaids (dihydroxyaluminum sodium carbonate) sits in plenty of medicine cabinets, yet its interaction list earns genuine caution rather than a shrug. Of 35 supplement and herbal ingredients on file, the lone major rating belongs to activated charcoal, which adsorbs many medications and can strip away their effect. The rest cluster into two patterns: fibers, gums, and mucilages that change how oral drugs are absorbed, and a handful, vitamin C among them, that can increase how much aluminum the body absorbs from the antacid itself.

That aluminum piece matters most for people whose kidneys cannot clear it well, where levels may climb toward toxicity. Of the remaining entries, 14 rate moderate and 20 minor, and most come down to timing, so spacing supplements well apart from a Rolaids dose covers a lot of ground. If activated charcoal is part of what you take, settle that pairing with your pharmacist before anything else.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 14 Minor 20 No known interaction 1,417

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Dihydroxyaluminum Sodium Carbonate: Top Interactions at a Glance

The Dihydroxyaluminum Sodium Carbonate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 35 interacting ingredients — plus 1,417 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Dihydroxyaluminum Sodium Carbonate Combinations Today

The Dihydroxyaluminum Sodium Carbonate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Betaine Hydrochloride + Dihydroxyaluminum Sodium Carbonatei

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.

Read the full interaction Minor Likelihood Possible Calamus + Dihydroxyaluminum Sodium Carbonatei

Theoretically, taking calamus might reduce the effectiveness of antacids.

Read the full interaction Minor Likelihood Possible Acerola + Dihydroxyaluminum Sodium Carbonatei

Theoretically, concomitant use of acerola with aluminum salts might increase the amount of aluminum absorbed.

Read the full interaction Minor Likelihood Possible Blessed Thistle + Dihydroxyaluminum Sodium Carbonatei

Theoretically, blessed thistle might decrease the effectiveness of antacids.

Read the full interaction Minor Likelihood Possible Quassia + Dihydroxyaluminum Sodium Carbonatei

Theoretically, due to reports that quassia increases stomach acid, quassia might decrease the effectiveness of antacids.

Read the full interaction Major Likelihood Probable Activated Charcoal + Dihydroxyaluminum Sodium Carbonatei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Dihydroxyaluminum Sodium Carbonate

All 1,452 ingredients in our database, ranked by severity — 35 with a Dihydroxyaluminum Sodium Carbonate interaction on file and 1,417 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Dihydroxyaluminum Sodium Carbonate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Betaine Hydrochloride with Dihydroxyaluminum Sodium Carbonate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.

Full Betaine Hydrochloride + Dihydroxyaluminum Sodium Carbonate answer

Can you take Calamus with Dihydroxyaluminum Sodium Carbonate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking calamus might reduce the effectiveness of antacids.

Full Calamus + Dihydroxyaluminum Sodium Carbonate answer

Can you take Acerola with Dihydroxyaluminum Sodium Carbonate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of acerola with aluminum salts might increase the amount of aluminum absorbed.

Full Acerola + Dihydroxyaluminum Sodium Carbonate answer

Can you take Blessed Thistle with Dihydroxyaluminum Sodium Carbonate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, blessed thistle might decrease the effectiveness of antacids.

Full Blessed Thistle + Dihydroxyaluminum Sodium Carbonate answer

Can you take Quassia with Dihydroxyaluminum Sodium Carbonate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, due to reports that quassia increases stomach acid, quassia might decrease the effectiveness of antacids.

Full Quassia + Dihydroxyaluminum Sodium Carbonate answer

Can you take Activated Charcoal with Dihydroxyaluminum Sodium Carbonate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Dihydroxyaluminum Sodium Carbonate answer

Can you take Coffee Charcoal with Dihydroxyaluminum Sodium Carbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Dihydroxyaluminum Sodium Carbonate answer

Can you take European Mandrake with Dihydroxyaluminum Sodium Carbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Dihydroxyaluminum Sodium Carbonate answer

Can you take Glucomannan with Dihydroxyaluminum Sodium Carbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Dihydroxyaluminum Sodium Carbonate answer

Can you take Rose Hip with Dihydroxyaluminum Sodium Carbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rose hip might increase the amount of aluminum absorbed from aluminum compounds.

Full Rose Hip + Dihydroxyaluminum Sodium Carbonate answer

Can you take Strontium with Dihydroxyaluminum Sodium Carbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Antacids can reduce the absorption of strontium, potentially decreasing its effectiveness.

Full Strontium + Dihydroxyaluminum Sodium Carbonate answer

Can you take Vitamin C with Dihydroxyaluminum Sodium Carbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.

Full Vitamin C + Dihydroxyaluminum Sodium Carbonate answer

Can you take Vitamin D with Dihydroxyaluminum Sodium Carbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.

Full Vitamin D + Dihydroxyaluminum Sodium Carbonate answer

Can you take Calcium with Dihydroxyaluminum Sodium Carbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Calcium citrate might increase aluminum absorption and toxicity.

Full Calcium + Dihydroxyaluminum Sodium Carbonate answer

Can you take Cinchona with Dihydroxyaluminum Sodium Carbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cinchona might decrease the effectiveness of antacids.

Full Cinchona + Dihydroxyaluminum Sodium Carbonate answer

Can you take Guar Gum with Dihydroxyaluminum Sodium Carbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Dihydroxyaluminum Sodium Carbonate answer

Can you take Gum Arabic with Dihydroxyaluminum Sodium Carbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Dihydroxyaluminum Sodium Carbonate answer

Can you take Magnesium with Dihydroxyaluminum Sodium Carbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Use of acid reducers may reduce the laxative effect of magnesium oxide.

Full Magnesium + Dihydroxyaluminum Sodium Carbonate answer

Can you take Slippery Elm with Dihydroxyaluminum Sodium Carbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Dihydroxyaluminum Sodium Carbonate answer

Can you take Tragacanth with Dihydroxyaluminum Sodium Carbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Dihydroxyaluminum Sodium Carbonate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Dihydroxyaluminum Sodium Carbonate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Dihydroxyaluminum Sodium Carbonate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Dihydroxyaluminum Sodium Carbonate sits in 3 interaction categories. Open any one to see what the group means:

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Dihydroxyaluminum Sodium Carbonate through this category.

Antacids 13 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

13 of the supplement ingredients on this page reach Dihydroxyaluminum Sodium Carbonate through this category.

Aluminum 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Dihydroxyaluminum Sodium Carbonate through this category.

About Dihydroxyaluminum Sodium Carbonate

A dietary supplement and antacid used to replace calcium in your diet and relieve heartburn or upset stomach.

Generic name: Dihydroxyaluminum Sodium Carbonate  ·  Brand name: Rolaids.

See the full Calcium Carbonate drug information

Related: does Dihydroxyaluminum Sodium Carbonate deplete any nutrients?

Dihydroxyaluminum Sodium Carbonate has 5 reported nutrient associations in the research literature — see the Dihydroxyaluminum Sodium Carbonate nutrient depletion report.

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Take a Supplement Product? Check the Whole Bottle Against Dihydroxyaluminum Sodium Carbonate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Dihydroxyaluminum Sodium Carbonate.

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Products that contain Dihydroxyaluminum Sodium Carbonate-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Dihydroxyaluminum Sodium Carbonate.

Super Greens Natural Berry Flavor by NutraChamps contains Rose Hip Special Two Multi Vitamin by Baar Nature's Blessing contains Rose Hip Cleanse Rite Advanced Colon Cleanse by NewtonEverett contains Rose Hip Calm Pressure by Dr. Gumman’s Integrative contains Rose Hip
Pharmacist Counseling Corner

Dihydroxyaluminum Sodium Carbonate & Supplements: Common Questions

What supplements interact with Dihydroxyaluminum Sodium Carbonate?
In our interaction database, 35 supplement and herbal ingredients have an interaction with Dihydroxyaluminum Sodium Carbonate on file — 1 rated major, 14 moderate, and 20 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Coffee Charcoal, European Mandrake.
Which Dihydroxyaluminum Sodium Carbonate supplement interactions are the most serious?
The 1 major-rated combination — led by Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Dihydroxyaluminum Sodium Carbonate?
That depends entirely on which supplement. The honest answer for Dihydroxyaluminum Sodium Carbonate is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Rolaids have the same supplement interactions as Dihydroxyaluminum Sodium Carbonate?
Yes — Rolaids all contain Dihydroxyaluminum Sodium Carbonate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Dihydroxyaluminum Sodium Carbonate deplete any vitamins or nutrients?
It might — Dihydroxyaluminum Sodium Carbonate has 5 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Dihydroxyaluminum Sodium Carbonate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Dihydroxyaluminum Sodium Carbonate and my other medications?
This page covers Dihydroxyaluminum Sodium Carbonate against supplements and herbal ingredients. Checking Dihydroxyaluminum Sodium Carbonate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Calcium Carbonate drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.