Calcium Carbonate

23 interactions
Also sold as: Alka-Mints Alka-Mints® Alkums Cal Gest Calcid® Calel-D® Caltrate Caltrate 600® Chooz Chooz® D-Cal Healthy Mama Miralac® Nutralox Os-Cal 500® OsCal 500 Pepto-Bismol Children's Rolaids® Titralac Titralac® Tums Tums®
About Calcium Carbonate

A dietary supplement and antacid used to replace calcium in your diet and relieve heartburn or upset stomach. Read the full Calcium Carbonate drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Octreotide Injection Cabotegravir Cefuroxime Digoxin Infigratinib Octreotide
14 Major 9 Moderate
All (23) Major (14) Moderate (9)

Major

Calcium Carbonate Acalabrutinib Calquence Reduced acalabrutinib exposure Details Calcium Carbonate Cabotegravir Apretude Reduced cabotegravir plasma concentrations Details Calcium Carbonate Cefuroxime Ceftin® Decreased cefuroxime axetil exposure Details Calcium Carbonate Digoxin Cardoxin® Reduced digoxin exposure Details Calcium Carbonate Erdafitinib Balversa Altered serum phosphate levels Details Calcium Carbonate Gefitinib Iressa Decreased exposure of gefitinib Details Calcium Carbonate Hydroxychloroquine Plaquenil Reduced hydroxychloroquine exposure Details Calcium Carbonate Infigratinib Truseltiq Decreased infigratinib plasma concentrations Details Calcium Carbonate Ketoconazole Topical Extina® Foam Reduced ketoconazole exposure and reduced efficacy of ketoconazole Details Calcium Carbonate Levothyroxine Ermeza Reduced levothyroxine absorption, reduced efficacy of levothyroxine and an increased risk of hypothyroidism Details Calcium Carbonate Mefenamic Acid Ponstel® Increased exposure to mefenamic acid Details Calcium Carbonate Neratinib Nerlynx Decreased neratinib exposure Details Calcium Carbonate Octreotide Bynfezia Decreased octreotide bioavailability Details Calcium Carbonate Octreotide Injection Bynfezia Decreased octreotide bioavailability Details

Moderate

Calcium Carbonate Bosutinib Bosulif Reduced bosutinib exposure Details Calcium Carbonate Captopril Capoten® Decreased captopril effectiveness Details Calcium Carbonate Cefpodoxime Banan® Decreased cefpodoxime effectiveness Details Calcium Carbonate Chloroquine Aralen® Decreased efficacy of chloroquine Details Calcium Carbonate Dasatinib Phyrago Reduced dasatinib exposure Details Calcium Carbonate Deflazacort Emflaza Decreased deflazacort effectiveness Details Calcium Carbonate Erlotinib Tarceva Reduced erlotinib exposure Details Calcium Carbonate Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Calcium Carbonate Gemifloxacin Factive Decreased oral gemifloxacin effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.