Eluxadoline

Generic name: Pronounced as (el" ux ad' oh leen)
Brand names
  • Viberzi®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 07/15/2020

Eluxadoline is used to treat irritable bowel syndrome with diarrhea (IBS-D; a condition that causes stomach pain, cramping, or loose or watery stools) in adults. Eluxadoline is in a class of medications called mu-opioid receptor agonists. It works by decreasing bowel activity.

Eluxadoline comes as a tablet to take by mouth. It is usually taken with food twice daily. Take eluxadoline at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take eluxadoline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Eluxadoline may be habit-forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking eluxadoline,

  • tell your doctor and pharmacist if you are allergic to eluxadoline, any other medications, or any of the ingredients in eluxadoline tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: alfentanil (Alfenta); alosetron (Lotronex); antibiotics such as ciprofloxacin (Cipro) and clarithromycin (Biaxin, in Prevpac); anticholinergic medications such as benztropine (Cogentin), dicyclomine (Bentyl), diphenhydramine (Benadryl); bupropion (Forfivo XL, Wellbutrin, Zyban, others); eltrombopag (Promacta); ergot-type medications such as dihydroergotamine (D.H.E. 45, Migranal) and ergotamine tartrate (Ergomar, in Cafergot, in Migergot); fentanyl (Abstral, Actiq, Duragesic, Sublimaze, others); fluconazole (Diflucan); gemfibrozil (Lopid); medications for HIV such as atazanavir (Reyataz, in Evotaz), lopinavir (Kaletra), ritonavir (Norvir, in Kaletra, in Viekira Pak), saquinavir (Invirase), and tipranavir (Aptivus); medications that suppress the immune system such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Astagraf, Envarsus XR, Prograf); opiate (narcotic) medications for pain; paroxetine (Brisdelle, Paxil, Pexeva); pimozide (Orap); quinidine (in Nuedexta); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); and rosuvastatin (Crestor). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • you should know that you may take loperamide (Imodium AD) occasionally to treat severe diarrhea while taking eluxadoline. Stop taking loperamide immediately if you become constipated.

  • tell your doctor if you have constipation now or if you often have constipation, if you drink or have ever drunk large amounts of alcohol (more than 3 alcoholic beverages a day), or if you do not have a gallbladder. Also tell your doctor if you have or have ever had bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder and small intestine), sphincter of Oddi dysfunction (blockage of bile or digestive juices flowing into the intestine that causes pain or jaundice), blockage in your intestines, pancreatitis (swelling of the pancreas that does not go away), or liver disease. Your doctor will probably tell you not to take eluxadoline.

  • tell your doctor if you have or have ever had kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking eluxadoline, call your doctor.

  • you should know that eluxadoline may make you drowsy, especially if you have liver disease. Do not drive a car or operate machinery until you know how this medication affects you.

  • tell your doctor if you regularly drink alcohol or sometimes drink large amounts of alcohol in a short time. Ask your doctor about the safe use of alcoholic beverages while you are taking eluxadoline. Drinking alcohol may increase the risk that you will develop pancreatitis.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it with food. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Eluxadoline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

  • Some side effects can be serious. If you experience any of these symptoms, stop taking eluxadoline and call your doctor immediately or get emergency medical treatment:

    • pain that begins in the upper stomach area but may spread to the back or shoulder with or without nausea and vomiting

    • severe constipation

    • rash; hives; swollen face or throat; shortness of breath; throat tightness; chest pain or tightness; or difficulty swallowing or breathing

  • Eluxadoline may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Eluxadoline is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The excretion of Repaglinide can be decreased when combined with Eluxadoline.
Atorvastatin Atorvastatin The serum concentration of Eluxadoline can be increased when it is combined with Atorvastatin.
Dolasetron Dolasetron The risk or severity of serotonin syndrome can be increased when Dolasetron is combined with Eluxadoline.
Bisacodyl Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Eluxadoline.
Candesartan Candesartan The serum concentration of Eluxadoline can be increased when it is combined with Candesartan.
Clopidogrel Clopidogrel Eluxadoline can cause a decrease in the absorption of Clopidogrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Diphenoxylate Diphenoxylate The risk or severity of constipation can be increased when Diphenoxylate is combined with Eluxadoline.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Eluxadoline can be increased when it is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The serum concentration of Eluxadoline can be increased when it is combined with Conjugated estrogens.
Magnesium Hydroxide Magnesium Hydroxide The therapeutic efficacy of Magnesium hydroxide can be decreased when used in combination with Eluxadoline.
Magnesium Oxide Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Eluxadoline.
Naratriptan Naratriptan The risk or severity of serotonin syndrome can be increased when Naratriptan is combined with Eluxadoline.
Paregoric Paregoric The risk or severity of constipation can be increased when Morphine is combined with Eluxadoline.
Pentazocine Pentazocine The risk or severity of constipation can be increased when Pentazocine is combined with Eluxadoline.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Eluxadoline.
Potassium Potassium The therapeutic efficacy of Potassium cation can be decreased when used in combination with Eluxadoline.
Psyllium Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Eluxadoline.
Reserpine Reserpine The serum concentration of Eluxadoline can be increased when it is combined with Reserpine.
Rizatriptan Rizatriptan The risk or severity of serotonin syndrome can be increased when Rizatriptan is combined with Eluxadoline.
Sumatriptan Sumatriptan The risk or severity of serotonin syndrome can be increased when Sumatriptan is combined with Eluxadoline.
Tacrolimus Tacrolimus The serum concentration of Eluxadoline can be increased when it is combined with Tacrolimus.
Tizanidine Tizanidine The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Tizanidine.
Zolmitriptan Zolmitriptan The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Eluxadoline.
Famotidine Injection Famotidine Injection The excretion of Eluxadoline can be decreased when combined with Famotidine.
Hydromorphone Injection Hydromorphone Injection The risk or severity of constipation can be increased when Hydromorphone is combined with Eluxadoline.
Meperidine Injection Meperidine Injection The risk or severity of constipation can be increased when Meperidine is combined with Eluxadoline.
Metoclopramide Injection Metoclopramide Injection The therapeutic efficacy of Eluxadoline can be increased when used in combination with Metoclopramide.
Morphine Injection Morphine Injection The risk or severity of constipation can be increased when Morphine is combined with Eluxadoline.
Zidovudine Injection Zidovudine Injection The excretion of Eluxadoline can be decreased when combined with Zidovudine.
Altretamine Altretamine Amphetamine may increase the analgesic activities of Eluxadoline.
Cyclosporine Cyclosporine The serum concentration of Eluxadoline can be increased when it is combined with Cyclosporine.
Ondansetron Ondansetron The risk or severity of serotonin syndrome can be increased when Ondansetron is combined with Eluxadoline.
Granisetron Granisetron The risk or severity of serotonin syndrome can be increased when Granisetron is combined with Eluxadoline.
Torsemide Torsemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Eluxadoline.
Olanzapine Olanzapine The risk or severity of constipation can be increased when Olanzapine is combined with Eluxadoline.
Alosetron Alosetron Alosetron may increase the constipating activities of Eluxadoline.
Pantoprazole Pantoprazole The serum concentration of Eluxadoline can be increased when it is combined with Pantoprazole.
Desloratadine Desloratadine The risk or severity of constipation can be increased when Desloratadine is combined with Eluxadoline.
Linezolid Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Eluxadoline.
Trimipramine Trimipramine The risk or severity of serotonin syndrome can be increased when Trimipramine is combined with Eluxadoline.
Glycopyrrolate Glycopyrrolate The risk or severity of constipation can be increased when Glycopyrronium is combined with Eluxadoline.
Sirolimus Sirolimus The serum concentration of Eluxadoline can be increased when it is combined with Sirolimus.
Eplerenone Eplerenone The therapeutic efficacy of Eplerenone can be decreased when used in combination with Eluxadoline.
Escitalopram Escitalopram The risk or severity of constipation can be increased when Escitalopram is combined with Eluxadoline.
Zonisamide Zonisamide The therapeutic efficacy of Zonisamide can be decreased when used in combination with Eluxadoline.
Aripiprazole Aripiprazole The risk or severity of constipation can be increased when Aripiprazole is combined with Eluxadoline.
Dexmethylphenidate Dexmethylphenidate The risk or severity of serotonin syndrome can be increased when Dexmethylphenidate is combined with Eluxadoline.
Ezetimibe Ezetimibe The excretion of Ezetimibe can be decreased when combined with Eluxadoline.
Atazanavir Atazanavir The serum concentration of Eluxadoline can be increased when it is combined with Atazanavir.
Almotriptan Almotriptan The risk or severity of serotonin syndrome can be increased when Almotriptan is combined with Eluxadoline.
Eletriptan Eletriptan The risk or severity of serotonin syndrome can be increased when Eletriptan is combined with Eluxadoline.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Eluxadoline.
Rosuvastatin Rosuvastatin The serum concentration of Rosuvastatin can be increased when it is combined with Eluxadoline.
Tegaserod Tegaserod The risk or severity of serotonin syndrome can be increased when Tegaserod is combined with Eluxadoline.
Frovatriptan Frovatriptan The risk or severity of serotonin syndrome can be increased when Frovatriptan is combined with Eluxadoline.
Progesterone Progesterone The serum concentration of Eluxadoline can be increased when it is combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of serotonin syndrome can be increased when Apomorphine is combined with Eluxadoline.
Protriptyline Protriptyline The risk or severity of serotonin syndrome can be increased when Protriptyline is combined with Eluxadoline.
Duloxetine Duloxetine The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Eluxadoline.
Trospium Trospium The risk or severity of constipation can be increased when Trospium is combined with Eluxadoline.
Bosentan Bosentan The excretion of Bosentan can be decreased when combined with Eluxadoline.
Eszopiclone Eszopiclone The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Eszopiclone.
Ganciclovir Ganciclovir The excretion of Eluxadoline can be decreased when combined with Ganciclovir.
Solifenacin Solifenacin The risk or severity of constipation can be increased when Solifenacin is combined with Eluxadoline.
Dextroamphetamine Dextroamphetamine Amphetamine may increase the analgesic activities of Eluxadoline.
Isocarboxazid Isocarboxazid The risk or severity of serotonin syndrome can be increased when Isocarboxazid is combined with Eluxadoline.
Darifenacin Darifenacin The risk or severity of constipation can be increased when Darifenacin is combined with Eluxadoline.
Fentanyl Fentanyl The risk or severity of constipation can be increased when Fentanyl is combined with Eluxadoline.
Pregabalin Pregabalin The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Pregabalin.
Tipranavir Tipranavir The serum concentration of Eluxadoline can be increased when it is combined with Tipranavir.
Rasagiline Rasagiline The risk or severity of serotonin syndrome can be increased when Rasagiline is combined with Eluxadoline.
Paliperidone Paliperidone The risk or severity of serotonin syndrome can be increased when Paliperidone is combined with Eluxadoline.
Lubiprostone Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Eluxadoline.
Darunavir Darunavir The serum concentration of Eluxadoline can be increased when it is combined with Darunavir.
Lisdexamfetamine Lisdexamfetamine Lisdexamfetamine may increase the analgesic activities of Eluxadoline.
Sorafenib Sorafenib The serum concentration of Eluxadoline can be increased when it is combined with Sorafenib.
Ivermectin Ivermectin The serum concentration of Eluxadoline can be increased when it is combined with Ivermectin.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Eluxadoline.
Nilotinib Nilotinib The serum concentration of Eluxadoline can be increased when it is combined with Nilotinib.
Desmopressin Desmopressin The risk or severity of hyponatremia can be increased when Eluxadoline is combined with Desmopressin.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Botulinum Toxin Type B.
Desvenlafaxine Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Desvenlafaxine is combined with Eluxadoline.
Leucovorin Injection Leucovorin Injection The excretion of Eluxadoline can be decreased when combined with Leucovorin.
Irinotecan Injection Irinotecan Injection The serum concentration of Eluxadoline can be increased when it is combined with Irinotecan.
Alvimopan Alvimopan The risk or severity of adverse effects can be increased when Eluxadoline is combined with Alvimopan.
Methylnaltrexone Injection Methylnaltrexone Injection Eluxadoline may increase the opioid antagonism activities of Methylnaltrexone.
Midazolam Midazolam The risk or severity of adverse effects can be increased when Eluxadoline is combined with Midazolam.
Naltrexone Injection Naltrexone Injection The risk or severity of constipation can be increased when Naltrexone is combined with Eluxadoline.
Eltrombopag Eltrombopag The serum concentration of Eluxadoline can be increased when it is combined with Eltrombopag.
Milnacipran Milnacipran The risk or severity of serotonin syndrome can be increased when Milnacipran is combined with Eluxadoline.
Sodium Phosphate Sodium Phosphate The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Eluxadoline.
Fesoterodine Fesoterodine The risk or severity of constipation can be increased when Fesoterodine is combined with Eluxadoline.
Iloperidone Iloperidone The risk or severity of serotonin syndrome can be increased when Iloperidone is combined with Eluxadoline.
Everolimus Everolimus The serum concentration of Eluxadoline can be increased when it is combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Eluxadoline.
Dronedarone Dronedarone The serum concentration of Eluxadoline can be increased when it is combined with Dronedarone.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Botulinum toxin type A.
Palonosetron Injection Palonosetron Injection The risk or severity of serotonin syndrome can be increased when Palonosetron is combined with Eluxadoline.
Tapentadol Tapentadol The risk or severity of constipation can be increased when Tapentadol is combined with Eluxadoline.
Pazopanib Pazopanib The serum concentration of Eluxadoline can be increased when it is combined with Pazopanib.
Asenapine Asenapine The risk or severity of serotonin syndrome can be increased when Asenapine is combined with Eluxadoline.
Pitavastatin Pitavastatin The serum concentration of Eluxadoline can be increased when it is combined with Pitavastatin.
Oxymorphone Oxymorphone The risk or severity of constipation can be increased when Oxymorphone is combined with Eluxadoline.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Botulinum toxin type A.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Eluxadoline can be increased when it is combined with Cabazitaxel.
Lurasidone Lurasidone The risk or severity of serotonin syndrome can be increased when Lurasidone is combined with Eluxadoline.
Vilazodone Vilazodone The risk or severity of serotonin syndrome can be increased when Vilazodone is combined with Eluxadoline.
Rilpivirine Rilpivirine The serum concentration of Eluxadoline can be increased when it is combined with Rilpivirine.
Telaprevir Telaprevir The serum concentration of Eluxadoline can be increased when it is combined with Glecaprevir.
Ticagrelor Ticagrelor Eluxadoline can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Clobazam Clobazam The risk or severity of adverse effects can be increased when Eluxadoline is combined with Clobazam.
Axitinib Axitinib The serum concentration of Eluxadoline can be increased when it is combined with Axitinib.
Cabergoline Cabergoline The risk or severity of serotonin syndrome can be increased when Cabergoline is combined with Eluxadoline.
Naloxone Injection Naloxone Injection The therapeutic efficacy of Eluxadoline can be decreased when used in combination with Naloxone.
Ambrisentan Ambrisentan The excretion of Ambrisentan can be decreased when combined with Eluxadoline.
Linaclotide Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Eluxadoline.
Teriflunomide Teriflunomide The serum concentration of Eluxadoline can be increased when it is combined with Teriflunomide.
Canagliflozin Canagliflozin The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Eluxadoline.
Methazolamide Methazolamide The therapeutic efficacy of Methazolamide can be decreased when used in combination with Eluxadoline.
Dabrafenib Dabrafenib The serum concentration of Eluxadoline can be increased when it is combined with Dabrafenib.
Dolutegravir Dolutegravir The excretion of Eluxadoline can be decreased when combined with Dolutegravir.
Levomilnacipran Levomilnacipran The risk or severity of serotonin syndrome can be increased when Levomilnacipran is combined with Eluxadoline.
Vortioxetine Vortioxetine The risk or severity of serotonin syndrome can be increased when Vortioxetine is combined with Eluxadoline.
Simeprevir Simeprevir The serum concentration of Eluxadoline can be increased when it is combined with Simeprevir.
Dapagliflozin Dapagliflozin The therapeutic efficacy of Dapagliflozin can be decreased when used in combination with Eluxadoline.
Idelalisib Idelalisib The serum concentration of Eluxadoline can be increased when it is combined with Idelalisib.
Testosterone Injection Testosterone Injection The excretion of Eluxadoline can be increased when combined with Testosterone.
Hydrocodone Hydrocodone The risk or severity of constipation can be increased when Hydrocodone is combined with Eluxadoline.
Caspofungin Injection Caspofungin Injection The serum concentration of Eluxadoline can be increased when it is combined with Caspofungin.
Methamphetamine Methamphetamine Metamfetamine may increase the analgesic activities of Eluxadoline.
Risperidone Injection Risperidone Injection The risk or severity of serotonin syndrome can be increased when Risperidone is combined with Eluxadoline.
Lenvatinib Lenvatinib The serum concentration of Eluxadoline can be increased when it is combined with Lenvatinib.
Naloxegol Naloxegol Eluxadoline may increase the opioid antagonism activities of Naloxegol.
Amiloride Amiloride The therapeutic efficacy of Amiloride can be decreased when used in combination with Eluxadoline.
Flibanserin Flibanserin The risk or severity of serotonin syndrome can be increased when Flibanserin is combined with Eluxadoline.
Daclatasvir Daclatasvir The serum concentration of Eluxadoline can be increased when it is combined with Daclatasvir.
Brexpiprazole Brexpiprazole The risk or severity of serotonin syndrome can be increased when Brexpiprazole is combined with Eluxadoline.
Ziprasidone Injection Ziprasidone Injection The risk or severity of constipation can be increased when Ziprasidone is combined with Eluxadoline.
Cariprazine Cariprazine The risk or severity of serotonin syndrome can be increased when Cariprazine is combined with Eluxadoline.
Cobimetinib Cobimetinib The excretion of Cobimetinib can be decreased when combined with Eluxadoline.
Venetoclax Venetoclax The serum concentration of Eluxadoline can be increased when it is combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Eluxadoline can be increased when it is combined with Cobicistat.
Selexipag Selexipag The excretion of Selexipag can be decreased when combined with Eluxadoline.
Pimavanserin Pimavanserin The risk or severity of serotonin syndrome can be increased when Pimavanserin is combined with Eluxadoline.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of constipation can be increased when Diphenhydramine is combined with Eluxadoline.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Furosemide can be decreased when used in combination with Eluxadoline.
Rucaparib Rucaparib The serum concentration of Eluxadoline can be increased when it is combined with Rucaparib.
Doxepin (Insomnia) Doxepin (Insomnia) The risk or severity of constipation can be increased when Doxepin is combined with Eluxadoline.
Plecanatide Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Eluxadoline.
Safinamide Safinamide The risk or severity of serotonin syndrome can be increased when Safinamide is combined with Eluxadoline.
Naldemedine Naldemedine The therapeutic efficacy of Eluxadoline can be decreased when used in combination with Naldemedine.
Enasidenib Enasidenib The serum concentration of Eluxadoline can be increased when it is combined with Enasidenib.
Letermovir Letermovir The excretion of Eluxadoline can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin The therapeutic efficacy of Ertugliflozin can be decreased when used in combination with Eluxadoline.
Buprenorphine Injection Buprenorphine Injection The risk or severity of constipation can be increased when Buprenorphine is combined with Eluxadoline.
Apalutamide Apalutamide The excretion of Eluxadoline can be decreased when combined with Apalutamide.
Penicillamine Penicillamine The excretion of Penicillamine can be decreased when combined with Eluxadoline.
Avatrombopag Avatrombopag The excretion of Eluxadoline can be decreased when combined with Avatrombopag.
Baricitinib Baricitinib The excretion of Eluxadoline can be decreased when combined with Baricitinib.
Lofexidine Lofexidine The risk or severity of serotonin syndrome can be increased when Lofexidine is combined with Eluxadoline.
Ivosidenib Ivosidenib The excretion of Eluxadoline can be decreased when combined with Ivosidenib.
Elagolix Elagolix The excretion of Elagolix can be decreased when combined with Eluxadoline.
Cannabidiol Cannabidiol The risk or severity of serotonin syndrome can be increased when Cannabidiol is combined with Eluxadoline.
Rifamycin Rifamycin The serum concentration of Eluxadoline can be increased when it is combined with Rifamycin.
Prucalopride Prucalopride The therapeutic efficacy of Prucalopride can be decreased when used in combination with Eluxadoline.
Magnesium Citrate Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Eluxadoline.
Acyclovir Ophthalmic Acyclovir Ophthalmic The excretion of Eluxadoline can be decreased when combined with Acyclovir.
Esomeprazole Injection Esomeprazole Injection The excretion of Eluxadoline can be decreased when combined with Esomeprazole.
Pexidartinib Pexidartinib The serum concentration of Eluxadoline can be increased when it is combined with Pexidartinib.
Istradefylline Istradefylline The serum concentration of Eluxadoline can be increased when it is combined with Istradefylline.
Fedratinib Fedratinib The serum concentration of Eluxadoline can be increased when it is combined with Fedratinib.
Lasmiditan Lasmiditan The risk or severity of serotonin syndrome can be increased when Eluxadoline is combined with Lasmiditan.
Bempedoic Acid Bempedoic Acid The serum concentration of Eluxadoline can be increased when it is combined with Bempedoic acid.
Remdesivir Injection Remdesivir Injection The serum concentration of Eluxadoline can be increased when it is combined with Remdesivir.
Fenfluramine Fenfluramine The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with Eluxadoline.
Fostemsavir Fostemsavir The serum concentration of Eluxadoline can be increased when it is combined with Fostemsavir.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The excretion of Belantamab mafodotin can be decreased when combined with Eluxadoline.
Pralsetinib Pralsetinib The serum concentration of Eluxadoline can be increased when it is combined with Pralsetinib.
Cabotegravir Cabotegravir The excretion of Eluxadoline can be decreased when combined with Cabotegravir.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Drospirenone can be decreased when used in combination with Eluxadoline.
Indomethacin Indomethacin The serum concentration of Eluxadoline can be increased when it is combined with Indomethacin.
Trazodone Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Eluxadoline.
Phenobarbital Phenobarbital The risk or severity of constipation can be increased when Phenobarbital is combined with Eluxadoline.
Metaxalone Metaxalone The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Metaxalone.
Methotrexate Injection Methotrexate Injection The excretion of Eluxadoline can be decreased when combined with Methotrexate.
Levorphanol Levorphanol The risk or severity of constipation can be increased when Levorphanol is combined with Eluxadoline.
Primidone Primidone The risk or severity of constipation can be increased when Primidone is combined with Eluxadoline.
Diethylpropion Diethylpropion Diethylpropion may increase the analgesic activities of Eluxadoline.
Chlorpromazine Chlorpromazine The risk or severity of constipation can be increased when Chlorpromazine is combined with Eluxadoline.
Diazepam Diazepam The risk or severity of adverse effects can be increased when Eluxadoline is combined with Diazepam.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Eluxadoline is combined with Oxazepam.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Eluxadoline is combined with Flurazepam.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Eluxadoline is combined with Clorazepic acid.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Eluxadoline is combined with Lorazepam.
Amantadine Amantadine The risk or severity of constipation can be increased when Amantadine is combined with Eluxadoline.
Codeine Codeine The risk or severity of constipation can be increased when Codeine is combined with Eluxadoline.
Meprobamate Meprobamate The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Meprobamate.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Eluxadoline is combined with Chlordiazepoxide.
Tranylcypromine Tranylcypromine The risk or severity of serotonin syndrome can be increased when Tranylcypromine is combined with Eluxadoline.
Phenelzine Phenelzine The risk or severity of serotonin syndrome can be increased when Phenelzine is combined with Eluxadoline.
Procarbazine Procarbazine The risk or severity of serotonin syndrome can be increased when Procarbazine is combined with Eluxadoline.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of serotonin syndrome can be increased when Ergoloid mesylate is combined with Eluxadoline.
Tetracycline Tetracycline The excretion of Eluxadoline can be decreased when combined with Tetracycline.
Minocycline Minocycline The excretion of Eluxadoline can be decreased when combined with Minocycline.
Prochlorperazine Prochlorperazine The risk or severity of hypotension and CNS depression can be increased when Prochlorperazine is combined with Eluxadoline.
Thioridazine Thioridazine The risk or severity of hypotension and CNS depression can be increased when Thioridazine is combined with Eluxadoline.
Trifluoperazine Trifluoperazine The risk or severity of hypotension and CNS depression can be increased when Trifluoperazine is combined with Eluxadoline.
Oxycodone Oxycodone The risk or severity of constipation can be increased when Oxycodone is combined with Eluxadoline.
Methadone Methadone The risk or severity of constipation can be increased when Methadone is combined with Eluxadoline.
Oxybutynin Oxybutynin The risk or severity of constipation can be increased when Oxybutynin is combined with Eluxadoline.
Benztropine Benztropine The risk or severity of constipation can be increased when Benzatropine is combined with Eluxadoline.
Maprotiline Maprotiline The risk or severity of constipation can be increased when Maprotiline is combined with Eluxadoline.
Ibuprofen Ibuprofen The excretion of Eluxadoline can be decreased when combined with Ibuprofen.
Trihexyphenidyl Trihexyphenidyl The risk or severity of constipation can be increased when Trihexyphenidyl is combined with Eluxadoline.
Orphenadrine Orphenadrine The risk or severity of constipation can be increased when Orphenadrine is combined with Eluxadoline.
Perphenazine Perphenazine The risk or severity of hypotension and CNS depression can be increased when Perphenazine is combined with Eluxadoline.
Fluphenazine Fluphenazine The risk or severity of hypotension and CNS depression can be increased when Fluphenazine is combined with Eluxadoline.
Phentermine Phentermine Phentermine may increase the analgesic activities of Eluxadoline.
Amoxapine Amoxapine The risk or severity of constipation can be increased when Amoxapine is combined with Eluxadoline.
Sulfasalazine Sulfasalazine The serum concentration of Eluxadoline can be increased when it is combined with Sulfasalazine.
Carbamazepine Carbamazepine The risk or severity of serotonin syndrome can be increased when Carbamazepine is combined with Eluxadoline.
Clonidine Clonidine The risk or severity of hypotension can be increased when Eluxadoline is combined with Clonidine.
Cimetidine Cimetidine The excretion of Eluxadoline can be decreased when combined with Cimetidine.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Eluxadoline is combined with Clonazepam.
Promethazine Promethazine The risk or severity of constipation can be increased when Promethazine is combined with Eluxadoline.
Digoxin Digoxin The serum concentration of Eluxadoline can be increased when it is combined with Digoxin.
Loxapine Loxapine The risk or severity of serotonin syndrome can be increased when Loxapine is combined with Eluxadoline.
Quinine Quinine The serum concentration of Eluxadoline can be increased when it is combined with Quinine.
Triamterene Triamterene The therapeutic efficacy of Triamterene can be decreased when used in combination with Eluxadoline.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Eluxadoline.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Eluxadoline.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Eluxadoline.
Metolazone Metolazone The therapeutic efficacy of Metolazone can be decreased when used in combination with Eluxadoline.
Isosorbide Isosorbide The therapeutic efficacy of Isosorbide can be decreased when used in combination with Eluxadoline.
Secobarbital Secobarbital The risk or severity of constipation can be increased when Secobarbital is combined with Eluxadoline.
Desipramine Desipramine The risk or severity of constipation can be increased when Desipramine is combined with Eluxadoline.
Amitriptyline Amitriptyline The risk or severity of constipation can be increased when Amitriptyline is combined with Eluxadoline.
Imipramine Imipramine The risk or severity of constipation can be increased when Imipramine is combined with Eluxadoline.
Probenecid Probenecid The excretion of Eluxadoline can be decreased when combined with Probenecid.
Quinidine Quinidine The risk or severity of constipation can be increased when Quinidine is combined with Eluxadoline.
Isoniazid Isoniazid The risk or severity of serotonin syndrome can be increased when Isoniazid is combined with Eluxadoline.
Rifampin Rifampin The serum concentration of Eluxadoline can be increased when it is combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of constipation can be increased when Disopyramide is combined with Eluxadoline.
Valproic Acid Valproic Acid The risk or severity of serotonin syndrome can be increased when Valproic acid is combined with Eluxadoline.
Butabarbital Butabarbital The risk or severity of constipation can be increased when Butabarbital is combined with Eluxadoline.
Liothyronine Liothyronine The excretion of Eluxadoline can be decreased when combined with Liothyronine.
Dextromethorphan Dextromethorphan The risk or severity of constipation can be increased when Dextromethorphan is combined with Eluxadoline.
Dinoprostone Dinoprostone The excretion of Eluxadoline can be decreased when combined with Dinoprostone.
Cyclobenzaprine Cyclobenzaprine The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Cyclobenzaprine.
Baclofen Baclofen The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Baclofen.
Doxylamine Doxylamine The risk or severity of constipation can be increased when Doxylamine is combined with Eluxadoline.
Cyproheptadine Cyproheptadine The risk or severity of constipation can be increased when Cyproheptadine is combined with Eluxadoline.
Chlorpheniramine Chlorpheniramine The risk or severity of serotonin syndrome can be increased when Chlorpheniramine is combined with Eluxadoline.
Brompheniramine Brompheniramine The risk or severity of constipation can be increased when Brompheniramine is combined with Eluxadoline.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Eluxadoline.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Eluxadoline.
Dantrolene Dantrolene The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Chlorzoxazone.
Carisoprodol Carisoprodol The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Carisoprodol.
Methocarbamol Methocarbamol The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Methocarbamol.
Pseudoephedrine Pseudoephedrine Pseudoephedrine may increase the analgesic activities of Eluxadoline.
Nortriptyline Nortriptyline The risk or severity of constipation can be increased when Nortriptyline is combined with Eluxadoline.
Spironolactone Spironolactone The therapeutic efficacy of Spironolactone can be decreased when used in combination with Eluxadoline.
Mercaptopurine Mercaptopurine The excretion of Eluxadoline can be decreased when combined with Mercaptopurine.
Butorphanol Injection Butorphanol Injection The risk or severity of constipation can be increased when Butorphanol is combined with Eluxadoline.
Nalbuphine Injection Nalbuphine Injection The risk or severity of constipation can be increased when Nalbuphine is combined with Eluxadoline.
Flavoxate Flavoxate The risk or severity of constipation can be increased when Flavoxate is combined with Eluxadoline.
Cefaclor Cefaclor The excretion of Eluxadoline can be decreased when combined with Cefaclor.
Cefadroxil Cefadroxil The excretion of Eluxadoline can be decreased when combined with Cefadroxil.
Cefazolin Injection Cefazolin Injection The excretion of Eluxadoline can be decreased when combined with Cefazolin.
Cephalexin Cephalexin The excretion of Eluxadoline can be decreased when combined with Cephalexin.
Acetazolamide Acetazolamide The therapeutic efficacy of Acetazolamide can be decreased when used in combination with Eluxadoline.
Nystatin Nystatin The serum concentration of Eluxadoline can be increased when it is combined with Nystatin.
Cefotaxime Injection Cefotaxime Injection The excretion of Eluxadoline can be decreased when combined with Cefotaxime.
Ketoconazole Ketoconazole The serum concentration of Eluxadoline can be increased when it is combined with Ketoconazole.
Vincristine Injection Vincristine Injection The serum concentration of Eluxadoline can be increased when it is combined with Vincristine.
Dipyridamole Dipyridamole The serum concentration of Eluxadoline can be increased when it is combined with Dipyridamole.
Vinblastine Vinblastine The serum concentration of Eluxadoline can be increased when it is combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Eluxadoline.
Aspirin Aspirin The excretion of Eluxadoline can be decreased when combined with Acetylsalicylic acid.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Eluxadoline is combined with Alprazolam.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Eluxadoline is combined with Temazepam.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Eluxadoline is combined with Triazolam.
Dicyclomine Dicyclomine The risk or severity of constipation can be increased when Dicyclomine is combined with Eluxadoline.
Hyoscyamine Hyoscyamine The risk or severity of constipation can be increased when Hyoscyamine is combined with Eluxadoline.
Propantheline Propantheline The risk or severity of constipation can be increased when Propantheline is combined with Eluxadoline.
Nifedipine Nifedipine The serum concentration of Eluxadoline can be increased when it is combined with Nifedipine.
Verapamil Verapamil The serum concentration of Eluxadoline can be increased when it is combined with Verapamil.
Pindolol Pindolol The risk or severity of serotonin syndrome can be increased when Pindolol is combined with Eluxadoline.
Piroxicam Piroxicam The excretion of Eluxadoline can be decreased when combined with Piroxicam.
Bumetanide Bumetanide The therapeutic efficacy of Bumetanide can be decreased when used in combination with Eluxadoline.
Indapamide Indapamide The therapeutic efficacy of Indapamide can be decreased when used in combination with Eluxadoline.
Ceftriaxone Injection Ceftriaxone Injection The excretion of Eluxadoline can be decreased when combined with Ceftriaxone.
Gemfibrozil Gemfibrozil The serum concentration of Eluxadoline can be increased when it is combined with Gemfibrozil.
Ketoprofen Ketoprofen The excretion of Eluxadoline can be decreased when combined with Ketoprofen.
Enalapril Enalapril The excretion of Eluxadoline can be decreased when combined with Enalapril.
Buspirone Buspirone The risk or severity of serotonin syndrome can be increased when Buspirone is combined with Eluxadoline.
Lovastatin Lovastatin The serum concentration of Eluxadoline can be increased when it is combined with Lovastatin.
Diclofenac Diclofenac The serum concentration of Eluxadoline can be increased when it is combined with Diclofenac.
Fluoxetine Fluoxetine The risk or severity of constipation can be increased when Fluoxetine is combined with Eluxadoline.
Clozapine Clozapine The risk or severity of constipation can be increased when Clozapine is combined with Eluxadoline.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Eluxadoline is combined with Estazolam.
Pravastatin Pravastatin The excretion of Eluxadoline can be decreased when combined with Pravastatin.
Simvastatin Simvastatin The serum concentration of Eluxadoline can be increased when it is combined with Simvastatin.
Cisapride Cisapride The risk or severity of serotonin syndrome can be increased when Cisapride is combined with Eluxadoline.
Fluvastatin Fluvastatin The serum concentration of Eluxadoline can be increased when it is combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of serotonin syndrome can be increased when Venlafaxine is combined with Eluxadoline.
Fluvoxamine Fluvoxamine The risk or severity of serotonin syndrome can be increased when Fluvoxamine is combined with Eluxadoline.
Nefazodone Nefazodone The risk or severity of serotonin syndrome can be increased when Nefazodone is combined with Eluxadoline.
Lamotrigine Lamotrigine The risk or severity of constipation can be increased when Lamotrigine is combined with Eluxadoline.
Tramadol Tramadol The risk or severity of constipation can be increased when Tramadol is combined with Eluxadoline.
Lansoprazole Lansoprazole The excretion of Eluxadoline can be decreased when combined with Lansoprazole.
Nicardipine Nicardipine The risk or severity of constipation can be increased when Nicardipine is combined with Eluxadoline.
Saquinavir Saquinavir The serum concentration of Eluxadoline can be increased when it is combined with Saquinavir.
Indinavir Indinavir The serum concentration of Eluxadoline can be increased when it is combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Eluxadoline can be increased when it is combined with Ritonavir.
Clomipramine Clomipramine The risk or severity of serotonin syndrome can be increased when Clomipramine is combined with Eluxadoline.
Mirtazapine Mirtazapine Eluxadoline may increase the serotonergic activities of Mirtazapine.
Valsartan Valsartan The serum concentration of Eluxadoline can be increased when it is combined with Valsartan.
Donepezil Donepezil The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Donepezil.
Nelfinavir Nelfinavir The serum concentration of Eluxadoline can be increased when it is combined with Nelfinavir.
Fexofenadine Fexofenadine The excretion of Fexofenadine can be decreased when combined with Eluxadoline.
Selegiline Selegiline The risk or severity of serotonin syndrome can be increased when Selegiline is combined with Eluxadoline.
Sertraline Sertraline The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Eluxadoline.
Raloxifene Raloxifene The excretion of Raloxifene can be decreased when combined with Eluxadoline.
Quetiapine Quetiapine The risk or severity of constipation can be increased when Quetiapine is combined with Eluxadoline.
Paroxetine Paroxetine The risk or severity of constipation can be increased when Paroxetine is combined with Eluxadoline.
Citalopram Citalopram The risk or severity of serotonin syndrome can be increased when Citalopram is combined with Eluxadoline.
Sildenafil Sildenafil The serum concentration of Eluxadoline can be increased when it is combined with Sildenafil.
Rosiglitazone Rosiglitazone The serum concentration of Eluxadoline can be increased when it is combined with Rosiglitazone.
Tolterodine Tolterodine The risk or severity of constipation can be increased when Tolterodine is combined with Eluxadoline.

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