Triclabendazole
Triclabendazole is an antiparasitic medication used to treat fascioliasis, a liver fluke infection, in patients 6 years of age and older.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 1 clinical label set within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
📖 Triclabendazole: Patient Information Guide
A plain-language walkthrough of Triclabendazole — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.
🎯What it's used for▾
Triclabendazole is an antiparasitic medicine approved for one specific infection:
- Fascioliasis: Egaten tablets are approved to treat this liver fluke infection — caused by Fasciola hepatica or Fasciola gigantica parasites — in patients 6 years of age and older. It works against both immature and mature worms.
⚙️How it works▾
Triclabendazole and its active breakdown products (metabolites called sulfoxide and sulfone) are absorbed directly through the outer skin-like surface of the Fasciola worm. Once inside the parasite, they disrupt the worm's ability to move, interfere with critical proteins (tubulin) needed for cell structure, and block the synthesis of proteins the worm needs to survive and reproduce. The result is paralysis and destruction of the parasite.
Resistance to triclabendazole has been reported, meaning the drug may not work in all cases. If your symptoms do not improve, let your doctor know.
💊How it's taken▾
Egaten is taken by mouth as two doses given 12 hours apart. Always take it with food — a meal dramatically increases how much of the drug your body absorbs (up to 3 times more). Tablets can be swallowed whole, cut in half with water, or crushed and stirred into applesauce (use within 4 hours if crushed).
- Two doses, 12 hours apart — not a long course of treatment
- Must be taken with a meal, not on an empty stomach
- Dose is based on body weight — your prescriber will calculate the right amount for you
🤒Side effects — in detail▾
The most common side effects seen in clinical trials include:
- Abdominal (belly) pain — very common; may also be related to the dying parasites
- Excessive sweating
- Dizziness or vertigo
- Nausea and vomiting
- Hives (urticaria) or itching
- Headache
- Decreased appetite
- Shortness of breath
- Temporary increases in liver enzyme levels
Contact your doctor right away if you develop an irregular heartbeat, fainting, yellowing of the skin or eyes (jaundice), or signs of a severe allergic reaction — these require prompt medical attention.
⚠️Warnings & precautions▾
- Heart rhythm (QT prolongation): Egaten lengthens the QTc interval — an electrical measurement in the heart — in a dose-related way. Taking it longer than recommended, combining it with other QT-prolonging drugs, having low potassium, using CYP1A2-inhibiting drugs, or having liver disease can all increase this risk. Your doctor may monitor your heart with an ECG. Stop taking Egaten and seek care immediately if you feel palpitations, rapid or irregular heartbeat, or faintness.
- Liver enzyme elevations: Temporary increases in liver enzymes and bilirubin have been observed after treatment. Some effects may also reflect the underlying infection resolving.
- Allergic reactions: Egaten is contraindicated (must not be used) in people with a known allergy to triclabendazole or related benzimidazole-class drugs.
🔀What it interacts with▾
Triclabendazole has not been studied in formal clinical drug interaction trials, but lab data point to several important concerns:
- CYP1A2 inhibitors (such as certain antibiotics and other drugs that slow this liver enzyme) — may raise triclabendazole levels, increasing the risk of heart rhythm problems
- QT-prolonging drugs — combining with other medications that affect heart rhythm raises the risk of a dangerous arrhythmia; tell your doctor about all medications
- CYP2C19 substrate drugs (which can include certain blood thinners, antidepressants, antifungals, and anti-seizure medications) — triclabendazole may temporarily increase their blood levels; your doctor may need to monitor and re-check levels after Egaten is finished
This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.
📋Before taking it▾
- Allergy: Do not take Egaten if you are allergic to triclabendazole, other benzimidazole medicines, or any ingredient in Egaten
- Heart rhythm problems: Tell your doctor if you have a history of long QT syndrome, abnormal ECGs, or if you take any medications that affect heart rhythm
- Low potassium (hypokalemia): This increases the risk of heart rhythm problems with Egaten — tell your doctor
- Liver disease: Egaten has not been studied in patients with liver impairment; use with extra caution and closer monitoring
- Kidney disease: Egaten has not been studied in patients with kidney impairment; discuss with your doctor
- Pregnancy: No human data exist; animal studies did not show birth defects, but the risks are not fully known — discuss with your doctor
- Breastfeeding: Triclabendazole may be present in breast milk; weigh the benefits and risks with your doctor
- Children under 6: Safety and effectiveness have not been established in children younger than 6 years old
- Older adults (65+): Use with caution — older patients are more likely to have heart, liver, or kidney conditions that may require closer monitoring
🚑If you take too much▾
One reported case of overdose (about 2.7 times the recommended dose) caused nausea; the patient recovered with treatment. If you or someone else takes too much Egaten, seek emergency medical care right away. The label advises monitoring the heart with an ECG and providing supportive treatment.
📡Pharmacodynamics — effects in the body▾
Egaten causes a dose-dependent lengthening of the QTc interval — a measure of the heart's electrical recharge time — even at the recommended dose. In a controlled study, the recommended dose produced an average increase in QTc of about 9 milliseconds; taking it for three times the recommended duration raised that increase to about 22 milliseconds. This is why heart monitoring may be needed in certain patients, and why taking Egaten longer than prescribed is not recommended.
🔬Pharmacokinetics — how your body processes it▾
After taking Egaten with a meal, peak levels of the drug's main active metabolite (sulfoxide) are reached in about 3 to 4 hours. Food has a major effect: taking Egaten with a meal roughly doubles to triples the amount the body absorbs compared to taking it on an empty stomach. Triclabendazole itself is rapidly converted in the liver — mainly by an enzyme called CYP1A2 — into active sulfoxide and sulfone metabolites that carry out most of its antiparasitic effect. These metabolites are highly protein-bound (over 96%) and are cleared with half-lives of roughly 8 to 14 hours. In animal studies, most of the drug is eliminated through the stool via the bile, with less than 10% going out in urine; human excretion data are not available. The drug's pharmacokinetics in patients with kidney or liver impairment have not been formally studied.
📦How to store it▾
Store in the original container. Store below 30°C (86°F).
📄 Written from Triclabendazole’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →
Supplements & herbs that interact with Triclabendazole
100 supplements and herbal products have documented interactions with Triclabendazole in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 1
- Moderate · 66
- Minor · 33
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
🩺 Pharmacist Counseling Corner
Quick, plain-English answers to the questions patients ask most about Triclabendazole — the kind of thing our pharmacy team would talk through with you at the counter.
What exactly is fascioliasis, and how did I get it? ▾
Do I really need to take this with food? What happens if I forget? ▾
My stomach is hurting after taking it. Is that normal? ▾
I heard this can affect my heart. Should I be worried? ▾
Can I take my other regular medications while on Egaten? ▾
Is this safe to take if I'm pregnant or breastfeeding? ▾
Is Triclabendazole available over the counter? ▾
When was Triclabendazole first available? ▾
Who makes Triclabendazole? ▾
💬 Answers drafted from Triclabendazole’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →
🧰 Keep exploring
💊 How Triclabendazole comes
Triclabendazole is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Tablet
How this form is used
- Egaten tablets are used to treat fascioliasis (a liver fluke infection caused by Fasciola species) in patients 6 years of age and older
- Egaten tablets must be taken by mouth with food to ensure adequate absorption
- Egaten tablets can be swallowed whole, divided in half and taken with water, or crushed and mixed with applesauce
- If Egaten tablets are crushed and mixed with applesauce, use the mixture within 4 hours
- Egaten is given as two doses taken 12 hours apart — follow your prescriber's instructions for the exact amount based on your body weight
📊 Triclabendazole across the U.S. market
How Triclabendazole appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
Also listed with the FDA, not a patient dose form: Powder (2) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
🔍 Compare Triclabendazole products
A representative set of FDA-listed product records for Triclabendazole — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Tablet | ||||
| 250 mg | Oral | Novartis Pharmaceuticals Corporation × 3 listings | NDA | View NDC → |
| 💊Bulk drug substance | ||||
| 1 kg/kg | — | Alivira Animal Health Limited | BULK INGREDIENT | View NDC → |
| 1 kg/kg | — | Rakshit Drugs Private Limited | BULK INGREDIENT | View NDC → |
Showing 5 of 5 products — FDA National Drug Code Directory. See every product, package size and price: browse all 5 Triclabendazole NDCs →
📈 What people report — real-world data (FDA FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Triclabendazole — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Triclabendazole in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
🏛️ The road to your pharmacy
How Triclabendazole went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
🚨 Recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
Source: openFDA drug enforcement (recall) reports.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 2118525 1 dose form · 1 strength
-
Dose form (SCDF) Oral Tablet RxCUI 2118605In current FDA listingsClinical drug / strength (SCD) 250 MGRxCUI 2118606
Look up RxCUI 2118525 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
📦 Supply & shortage status
Whether Triclabendazole is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
🏷️ Sold under these brand names
🏭 Manufacturers & labelers
RxNorm drug class
Triclabendazole belongs to the Anthelmintic class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
🔬 Where this comes from
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How we combine label and product data
HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 1 FDA-filed SPL label set within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.
For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Novartis Pharmaceuticals Corporation is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.
This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.