Lixisenatide Injection

Generic name: Pronounced as (lix" i sen' a tide)
Brand names
  • Adlyxin®
  • Soliqua® (as a combination product containing Insulin Glargine and Lixisenatide)
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 03/15/2017

Lixisenatide injection is used along with diet and exercise to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Lixisenatide injection is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). Lixisenatide is not used instead of insulin to treat people with diabetes who need insulin. Lixisenatide injection is in a class of medications called incretin mimetics. It works by stimulating the pancreas to secrete insulin when blood sugar levels are high. Insulin helps move sugar from the blood into other body tissues where it is used for energy. Lixisenatide injection also slows the emptying of the stomach and causes a decrease in appetite.

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with lixisenatide injection and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.

Lixisenatide injection comes as a prefilled dosing pen to inject subcutaneously (under the skin). It is usually injected once a day, within one hour (60 minutes) before the first meal of the day. Use lixisenatide injection at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use lixisenatide injection exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of lixisenatide and then increase your dose after 14 days.

Lixisenatide injection controls diabetes but does not cure it. Continue to use lixisenatide injection even if you feel well. Do not stop using lixisenatide injection without talking to your doctor.

You will need to buy needles separately. Ask your doctor or pharmacist what type of needles you will need to inject your medication. Be sure to read and understand the manufacturer's instructions for injecting lixisenatide. Also make sure you know how and when to set up a new pen. If you are blind or have poor eyesight do not use this pen without help. Ask your doctor or pharmacist to show you how to use the pen. Follow the directions carefully.

Always look at the lixisenatide solution before you inject it. It should be clear, colorless, and free of particles. Do not use lixisenatide if it is colored, cloudy, thickened, or contains solid particles, or if the expiration date on the pen has passed.

Lixisenatide injection can be administered in the thigh (upper leg), abdomen (stomach area), or upper arm. Use a different site for each injection. Allow the pen to warm to room temperature before using it if stored in the refrigerator.

Never reuse needles and never share needles or pens. Always remove the needle right after you inject your dose. Throw away needles in a puncture-resistant container. Ask your doctor or pharmacist how to dispose of the puncture resistant container.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking lixisenatide injection,

  • tell your doctor and pharmacist if you are allergic to lixisenatide, exenatide (Bydureon, Byetta), liraglutide (Saxenda, Victoza), any other medications, or any of the ingredients in lixisenatide injection. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. It is especially important to tell your doctor about all the medications you take by mouth because lixisenatide may change the way your body absorbs these medications. If you are taking pain medications such as acetaminophen (Tylenol), or antibiotics, take them at least one hour before lixisenatide injection. If you are taking oral contraceptives (birth control pills) take them at least 1 hour before, or 11 hours after using lixisenatide injection. Also, be sure to mention any of the following medications: chlorpropamide (Diabinese), digoxin (Lanoxin), glimepiride (Amaryl, in Duetact), glipizide (Glucotrol), glyburide (DiaBeta, Glynase, in Glucovance), insulin, tolazamide, and tolbutamide. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you drink or have ever drunk large amounts of alcohol, or if you have or have ever had severe stomach problems, including gastroparesis (slowed movement of food from the stomach to the small intestine), or problems digesting food; pancreatitis (swelling of the pancreas); gallstones (solid deposits that form in the gallbladder); or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking lixisenatide injection, call your doctor.

  • ask your doctor what to do if there is a large change in your diet, exercise, or weight; or if you get sick, develop an infection or fever, experience unusual stress, or are injured. These changes and conditions can affect your blood sugar and the amount of lixisenatide injection you may need.

Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. It is important to eat a healthy diet.

Inject the missed dose within 1 hour (60 minutes) before your next meal. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not inject a double dose to make up for a missed one.

  • This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.

  • Lixisenatide injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • diarrhea

    • constipation

    • indigestion

    • bloating

    • headache

    • pain, itching, or redness at the injection site

  • Some side effects can be serious. If you experience any of these symptoms, stop taking lixisenatide injection and call your doctor immediately or get emergency medical treatment:

    • ongoing pain that begins in the upper left or middle of the stomach but may spread to the back, with or without vomiting

    • hives

    • rash

    • itching

    • pounding heartbeat

    • fainting or feeling dizzy

    • swelling of the eyes, face, mouth, tongue, throat, feet, ankles, or lower legs

    • difficulty swallowing or breathing

    • hoarseness

    • decreased urination,

    • very dry mouth or skin or extreme thirst

  • Lixisenatide injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it away from light, heat, dust and dirt. Store unused lixisenatide pens in the refrigerator (36°F to 46°F [2°C to 8°C]). Once a lixisenatide pen is in use, store it at room temperature (below 86°F [30°C]) with its cap on. Do not freeze. Do not use lixisenatide if it has been frozen. Dispose of lixisenatide pens in a puncture-resistant container after 14 days from its first use, even if there is some solution left in the pen.

When traveling, be sure to keep lixisenatide pens dry. Unused pens should be refrigerated or kept at a cold temperature between 36°F to 46°F (2°C to 8°C). Pens that are in use can be stored at room temperature up to 86°F [30°C] (not in a car glove compartment or other hot place).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • nausea

  • vomiting

  • diarrhea

  • abdominal pain or bloating

  • indigestion

  • constipation

Keep all appointments with your doctor and the laboratory. Your blood sugar and glycosylated hemoglobin (HbA1c) should be checked regularly to determine your response to lixisenatide injection. Your doctor will tell you how to check your response to this medication by measuring your blood or urine sugar levels at home. Follow these instructions carefully.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The therapeutic efficacy of Lixisenatide can be increased when used in combination with Moxifloxacin.
Repaglinide Repaglinide The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Lixisenatide.
Cilostazol Cilostazol Cilostazol may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Fenofibrate Fenofibrate Fenofibrate may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Guanfacine Guanfacine Guanfacine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Magnesium Hydroxide Magnesium Hydroxide Magnesium hydroxide may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Miglitol Miglitol The risk or severity of hypoglycemia can be increased when Miglitol is combined with Lixisenatide.
Mycophenolate Mycophenolate Mycophenolic acid may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Olsalazine Olsalazine Olsalazine may increase the hypoglycemic activities of Lixisenatide.
Penbutolol Penbutolol The therapeutic efficacy of Lixisenatide can be increased when used in combination with Acebutolol.
Potassium Potassium Potassium cation may increase the excretion rate of Lixisenatide which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone The risk or severity of hyperglycemia can be increased when Prednisone is combined with Lixisenatide.
Ranitidine Ranitidine Ranitidine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Reserpine Reserpine Reserpine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Rizatriptan Rizatriptan Rizatriptan may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Sumatriptan Sumatriptan The therapeutic efficacy of Lixisenatide can be increased when used in combination with Sumatriptan.
Tacrolimus Tacrolimus The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Tacrolimus.
Triamcinolone Triamcinolone The risk or severity of hyperglycemia can be increased when Triamcinolone is combined with Lixisenatide.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection The risk or severity of hypoglycemia can be increased when Lixisenatide is combined with Fluconazole.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection Hydromorphone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Levofloxacin Injection Levofloxacin Injection The therapeutic efficacy of Lixisenatide can be increased when used in combination with Levofloxacin.
Meperidine Injection Meperidine Injection Meperidine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of hyperglycemia can be increased when Methylprednisolone is combined with Lixisenatide.
Metoclopramide Injection Metoclopramide Injection Metoclopramide may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Lixisenatide may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine Altretamine Amphetamine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Cyclosporine Cyclosporine Cyclosporine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Torsemide Torsemide The therapeutic efficacy of Lixisenatide can be increased when used in combination with Torasemide.
Olanzapine Olanzapine The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Olanzapine.
Hydroxychloroquine Hydroxychloroquine The therapeutic efficacy of Lixisenatide can be increased when used in combination with Hydroxychloroquine.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Temozolomide Temozolomide Temozolomide may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Zaleplon Zaleplon Zaleplon may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Linezolid Linezolid Linezolid may increase the hypoglycemic activities of Lixisenatide.
Trimipramine Trimipramine Trimipramine may decrease the hypoglycemic activities of Lixisenatide.
Perindopril Perindopril Perindopril may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Sirolimus Sirolimus The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Sirolimus.
Epinephrine Injection Epinephrine Injection The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Epinephrine.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Lixisenatide which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The risk or severity of hypoglycemia can be increased when Escitalopram is combined with Lixisenatide.
Zonisamide Zonisamide The therapeutic efficacy of Lixisenatide can be increased when used in combination with Zonisamide.
Aripiprazole Aripiprazole The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Aripiprazole.
Atomoxetine Atomoxetine Atomoxetine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Atazanavir Atazanavir The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Atazanavir.
Almotriptan Almotriptan Almotriptan may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Rosuvastatin Rosuvastatin The therapeutic efficacy of Lixisenatide can be increased when used in combination with Rosuvastatin.
Emtricitabine Emtricitabine Emtricitabine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Memantine Memantine Memantine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Tadalafil Tadalafil Tadalafil may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Fosamprenavir Fosamprenavir The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Fosamprenavir.
Gemifloxacin Gemifloxacin The therapeutic efficacy of Lixisenatide can be increased when used in combination with Gemifloxacin.
Progesterone Progesterone The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Progesterone.
Oxandrolone Oxandrolone Oxandrolone may increase the hypoglycemic activities of Lixisenatide.
Protriptyline Protriptyline Protriptyline may decrease the hypoglycemic activities of Lixisenatide.
Duloxetine Duloxetine The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Lixisenatide.
Norethindrone Norethindrone The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Norethisterone.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Bosentan Bosentan The therapeutic efficacy of Lixisenatide can be increased when used in combination with Bosentan.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Eszopiclone Eszopiclone Eszopiclone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ganciclovir Ganciclovir Ganciclovir may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection Lixisenatide may increase the hypoglycemic activities of Insulin aspart.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Valganciclovir Valganciclovir Valganciclovir may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Adefovir Adefovir Adefovir may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Pramlintide Injection Pramlintide Injection The risk or severity of hypoglycemia can be increased when Pramlintide is combined with Lixisenatide.
Exenatide Injection Exenatide Injection The risk or severity of hypoglycemia can be increased when Exenatide is combined with Lixisenatide.
Isocarboxazid Isocarboxazid Isocarboxazid may increase the hypoglycemic activities of Lixisenatide.
Ramelteon Ramelteon Ramelteon may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Fentanyl Fentanyl Fentanyl may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Pregabalin Pregabalin The risk or severity of hypoglycemia can be increased when Pregabalin is combined with Lixisenatide.
Tipranavir Tipranavir The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Tipranavir.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection Lixisenatide may increase the hypoglycemic activities of Insulin detemir.
Ranolazine Ranolazine Ranolazine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Rasagiline Rasagiline Rasagiline may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Sitagliptin Sitagliptin The risk or severity of hypoglycemia can be increased when Sitagliptin is combined with Lixisenatide.
Varenicline Varenicline Varenicline may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Albuterol Albuterol Salbutamol may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Paliperidone Paliperidone The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Paliperidone.
Clofarabine Injection Clofarabine Injection Clofarabine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection Lixisenatide may increase the hypoglycemic activities of Insulin glulisine.
Lubiprostone Lubiprostone Lubiprostone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Bismuth Subsalicylate Bismuth Subsalicylate Bismuth subsalicylate may increase the hypoglycemic activities of Lixisenatide.
Darunavir Darunavir The therapeutic efficacy of Lixisenatide can be increased when used in combination with Darunavir.
Pemetrexed Injection Pemetrexed Injection Lixisenatide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Vorinostat Vorinostat The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Vorinostat.
Sorafenib Sorafenib Sorafenib may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Sunitinib Sunitinib The risk or severity of hypoglycemia can be increased when Sunitinib is combined with Lixisenatide.
Levocetirizine Levocetirizine Levocetirizine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Pegaptanib may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Temsirolimus Temsirolimus The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Temsirolimus.
Lenalidomide Lenalidomide Lenalidomide may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Nilotinib Nilotinib The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Nilotinib.
Budesonide Budesonide The risk or severity of hyperglycemia can be increased when Budesonide is combined with Lixisenatide.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Doripenem Injection Doripenem Injection Doripenem may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Arsenic trioxide.
Desvenlafaxine Desvenlafaxine The risk or severity of hypoglycemia can be increased when Desvenlafaxine is combined with Lixisenatide.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Nebivolol Nebivolol The therapeutic efficacy of Lixisenatide can be increased when used in combination with Nebivolol.
Certolizumab Injection Certolizumab Injection Certolizumab pegol may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Methylnaltrexone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Midazolam Midazolam Midazolam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Milnacipran Milnacipran The risk or severity of hypoglycemia can be increased when Milnacipran is combined with Lixisenatide.
Plerixafor Injection Plerixafor Injection Plerixafor may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Fesoterodine Fesoterodine Fesoterodine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Betaxolol Betaxolol The therapeutic efficacy of Lixisenatide can be increased when used in combination with Betaxolol.
Iloperidone Iloperidone The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Iloperidone.
Prasugrel Prasugrel Prasugrel may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Everolimus Everolimus The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Lixisenatide which could result in a lower serum level and potentially a reduction in efficacy.
Pralatrexate Injection Pralatrexate Injection Pralatrexate may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Palonosetron may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Saxagliptin Saxagliptin The risk or severity of hypoglycemia can be increased when Saxagliptin is combined with Lixisenatide.
Telavancin Injection Telavancin Injection Telavancin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Topotecan Topotecan Topotecan may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Asenapine Asenapine The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Asenapine.
Levonorgestrel Levonorgestrel The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Levonorgestrel.
Liraglutide Injection Liraglutide Injection The risk or severity of hypoglycemia can be increased when Liraglutide is combined with Lixisenatide.
Dalfampridine Dalfampridine Dalfampridine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Lurasidone Lurasidone The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Lurasidone.
Acetaminophen Injection Acetaminophen Injection Acetaminophen may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ipilimumab Injection Ipilimumab Injection Ipilimumab may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Roflumilast Roflumilast Roflumilast may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Linagliptin Linagliptin The risk or severity of hypoglycemia can be increased when Linagliptin is combined with Lixisenatide.
Triptorelin Injection Triptorelin Injection The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Triptorelin.
Rivaroxaban Rivaroxaban Rivaroxaban may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ruxolitinib Ruxolitinib Ruxolitinib may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Clobazam Clobazam Clobazam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Vemurafenib Vemurafenib The therapeutic efficacy of Lixisenatide can be increased when used in combination with Vemurafenib.
Deferiprone Deferiprone Deferiprone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Naloxone Injection Naloxone Injection Naloxone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Enzalutamide Enzalutamide Enzalutamide may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Mirabegron Mirabegron Mirabegron may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of hyperglycemia can be increased when Corticotropin is combined with Lixisenatide.
Lorcaserin Lorcaserin The risk or severity of hypoglycemia can be increased when Mecasermin is combined with Lixisenatide.
Teduglutide Injection Teduglutide Injection Teduglutide may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Alogliptin Alogliptin The risk or severity of hypoglycemia can be increased when Alogliptin is combined with Lixisenatide.
Pomalidomide Pomalidomide Pomalidomide may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Canagliflozin Canagliflozin Canagliflozin may increase the hypoglycemic activities of Lixisenatide.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Lixisenatide which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Dabrafenib.
Trametinib Trametinib Trametinib may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Levomilnacipran Levomilnacipran The risk or severity of hypoglycemia can be increased when Levomilnacipran is combined with Lixisenatide.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Vortioxetine Vortioxetine Vortioxetine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Simeprevir Simeprevir The therapeutic efficacy of Lixisenatide can be increased when used in combination with Simeprevir.
Sofosbuvir Sofosbuvir Sofosbuvir may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the hypoglycemic activities of Lixisenatide.
Apremilast Apremilast Apremilast may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Droxidopa Droxidopa Droxidopa may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ceritinib Ceritinib The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Ceritinib.
Albiglutide Injection Albiglutide Injection The risk or severity of hypoglycemia can be increased when Albiglutide is combined with Lixisenatide.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Empagliflozin Empagliflozin The risk or severity of hypoglycemia can be increased when Empagliflozin is combined with Lixisenatide.
Dulaglutide Injection Dulaglutide Injection The risk or severity of hypoglycemia can be increased when Dulaglutide is combined with Lixisenatide.
Edoxaban Edoxaban Edoxaban may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Methamphetamine Methamphetamine Metamfetamine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Tasimelteon Tasimelteon Tasimelteon may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Lanreotide Injection Lanreotide Injection The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Lanreotide.
Risperidone Injection Risperidone Injection The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Risperidone.
Insulin Human Inhalation Insulin Human Inhalation Lixisenatide may increase the hypoglycemic activities of Insulin human.
Haloperidol Injection Haloperidol Injection The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Haloperidol.
Amiloride Amiloride Amiloride may increase the excretion rate of Lixisenatide which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan Macitentan Macitentan may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Prednisolone Prednisolone The risk or severity of hyperglycemia can be increased when Prednisolone is combined with Lixisenatide.
Brexpiprazole Brexpiprazole The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Ziprasidone.
Penicillin G Procaine Injection Penicillin G Procaine Injection Lixisenatide may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection Lixisenatide may increase the hypoglycemic activities of Insulin degludec.
Ixazomib Ixazomib Lixisenatide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad Lixisenatide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The risk or severity of hyperglycemia can be increased when Dexamethasone is combined with Lixisenatide.
Brivaracetam Injection Brivaracetam Injection Brivaracetam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Lixisenatide can be increased when used in combination with Furosemide.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin may decrease the hypoglycemic activities of Lixisenatide.
Deutetrabenazine Deutetrabenazine Lixisenatide may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Lixisenatide may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The risk or severity of hyperglycemia can be increased when Deflazacort is combined with Lixisenatide.
Safinamide Safinamide Safinamide may increase the hypoglycemic activities of Lixisenatide.
Naldemedine Naldemedine Lixisenatide may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Benznidazole Benznidazole Lixisenatide may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin The therapeutic efficacy of Lixisenatide can be increased when used in combination with Delafloxacin.
Semaglutide Injection Semaglutide Injection The risk or severity of hypoglycemia can be increased when Lixisenatide is combined with Semaglutide.
Ertugliflozin Ertugliflozin The therapeutic efficacy of Lixisenatide can be increased when used in combination with Ertugliflozin.
Apalutamide Apalutamide Lixisenatide may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Baricitinib Baricitinib Lixisenatide may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine Lofexidine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Plazomicin Injection Plazomicin Injection Lixisenatide may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Stiripentol Stiripentol Stiripentol may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Prucalopride Prucalopride Prucalopride may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Solriamfetol Solriamfetol Lixisenatide may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Pitolisant Pitolisant Lixisenatide may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Teprotumumab-trbw Injection Teprotumumab-trbw Injection The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Teprotumumab.
Octreotide Octreotide The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Octreotide.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Drospirenone.
Viloxazine Viloxazine Viloxazine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Naproxen Naproxen Naproxen may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Isotretinoin Isotretinoin Isotretinoin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Floxuridine Floxuridine Floxuridine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Metaxalone Metaxalone Metaxalone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection Methotrexate may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Methsuximide Methsuximide The risk or severity of hypoglycemia can be increased when Methsuximide is combined with Lixisenatide.
Chlorpromazine Chlorpromazine The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Chlorpromazine.
Diazepam Diazepam Diazepam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Oxazepam Oxazepam Oxazepam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Flurazepam Flurazepam Flurazepam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Clorazepate Clorazepate Clorazepic acid may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Lorazepam Lorazepam Lorazepam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Carmustine Carmustine Carmustine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Amantadine Amantadine Amantadine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Codeine Codeine Codeine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Bromocriptine Bromocriptine The risk or severity of hypoglycemia can be increased when Bromocriptine is combined with Lixisenatide.
Tranylcypromine Tranylcypromine Tranylcypromine may increase the hypoglycemic activities of Lixisenatide.
Phenelzine Phenelzine Phenelzine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Procarbazine Procarbazine Procarbazine may increase the hypoglycemic activities of Lixisenatide.
Tetracycline Tetracycline Tetracycline may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Sulfadiazine Sulfadiazine The therapeutic efficacy of Lixisenatide can be increased when used in combination with Sulfadiazine.
Methadone Methadone Methadone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Maprotiline Maprotiline Maprotiline may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Azathioprine Azathioprine Azathioprine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Phentermine Phentermine The therapeutic efficacy of Lixisenatide can be increased when used in combination with Phentermine.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Amoxapine Amoxapine Amoxapine may decrease the hypoglycemic activities of Lixisenatide.
Sulfasalazine Sulfasalazine Sulfasalazine may increase the hypoglycemic activities of Lixisenatide.
Hydrocortisone Hydrocortisone The risk or severity of hyperglycemia can be increased when Hydrocortisone is combined with Lixisenatide.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Carbamazepine Carbamazepine Lixisenatide may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Methyldopa Methyldopa Methyldopa may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Hydralazine Hydralazine Hydralazine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Cimetidine Cimetidine Cimetidine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Warfarin Warfarin Lixisenatide can cause a decrease in the absorption of Warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Clonazepam Clonazepam Clonazepam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Loperamide Loperamide The risk or severity of hypoglycemia can be increased when Loperamide is combined with Lixisenatide.
Promethazine Promethazine Promethazine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Digoxin Digoxin Lixisenatide may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine Chloroquine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Quinine Quinine The risk or severity of hypoglycemia can be increased when Quinine is combined with Lixisenatide.
Ethosuximide Ethosuximide The risk or severity of hypoglycemia can be increased when Ethosuximide is combined with Lixisenatide.
Triamterene Triamterene Triamterene may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Chlorothiazide.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Chlorthalidone.
Metolazone Metolazone The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Metolazone.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Lixisenatide which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital Secobarbital may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Desipramine Desipramine Desipramine may decrease the hypoglycemic activities of Lixisenatide.
Amitriptyline Amitriptyline Amitriptyline may decrease the hypoglycemic activities of Lixisenatide.
Imipramine Imipramine Imipramine may decrease the hypoglycemic activities of Lixisenatide.
Probenecid Probenecid The therapeutic efficacy of Lixisenatide can be increased when used in combination with Probenecid.
Quinidine Quinidine Lixisenatide may decrease the excretion rate of Quinidine which could result in a higher serum level.
Procainamide Procainamide Lixisenatide may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid Isoniazid may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Disopyramide Disopyramide The risk or severity of hypoglycemia can be increased when Disopyramide is combined with Lixisenatide.
Butabarbital Butabarbital Butabarbital may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Levothyroxine Levothyroxine The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Levothyroxine.
Liothyronine Liothyronine The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Liothyronine.
Methimazole Methimazole Methimazole may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Chlorpropamide Chlorpropamide Lixisenatide may increase the hypoglycemic activities of Chlorpropamide.
Tolbutamide Tolbutamide Lixisenatide may increase the hypoglycemic activities of Tolbutamide.
Tolazamide Tolazamide Lixisenatide may increase the hypoglycemic activities of Tolazamide.
Niacin Niacin The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Niacin.
Baclofen Baclofen The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Baclofen.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Hydrochlorothiazide.
Chlorzoxazone Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Danazol Danazol The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Danazol.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The therapeutic efficacy of Lixisenatide can be increased when used in combination with Propranolol.
Pseudoephedrine Pseudoephedrine The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Pseudoephedrine.
Nortriptyline Nortriptyline Nortriptyline may decrease the hypoglycemic activities of Lixisenatide.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Lixisenatide which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Phytonadione Phytonadione Phylloquinone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Nadolol Nadolol The therapeutic efficacy of Lixisenatide can be increased when used in combination with Nadolol.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Fluoxymesterone Fluoxymesterone Fluoxymesterone may increase the hypoglycemic activities of Lixisenatide.
Flavoxate Flavoxate Flavoxate may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Colchicine Colchicine Colchicine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Dacarbazine Dacarbazine Dacarbazine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Acetazolamide Acetazolamide The therapeutic efficacy of Lixisenatide can be increased when used in combination with Acetazolamide.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Pyrantel Pyrantel Lixisenatide may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Etacrynic acid.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Metoprolol Metoprolol The therapeutic efficacy of Lixisenatide can be increased when used in combination with Metoprolol.
Aspirin Aspirin The risk or severity of hypoglycemia can be increased when Acetylsalicylic acid is combined with Lixisenatide.
Salsalate Salsalate Salsalate may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Alprazolam Alprazolam Alprazolam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Temazepam Temazepam Temazepam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Triazolam Triazolam Triazolam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Dicyclomine Dicyclomine Dicyclomine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Propantheline Propantheline Propantheline may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Diltiazem Diltiazem The risk or severity of hypoglycemia can be increased when Diltiazem is combined with Lixisenatide.
Nifedipine Nifedipine The risk or severity of hypoglycemia can be increased when Nifedipine is combined with Lixisenatide.
Timolol Timolol The therapeutic efficacy of Lixisenatide can be increased when used in combination with Timolol.
Verapamil Verapamil The risk or severity of hypoglycemia can be increased when Verapamil is combined with Lixisenatide.
Atenolol Atenolol The therapeutic efficacy of Lixisenatide can be increased when used in combination with Atenolol.
Pindolol Pindolol The therapeutic efficacy of Lixisenatide can be increased when used in combination with Pindolol.
Cisplatin Injection Cisplatin Injection Lixisenatide may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may increase the hypoglycemic activities of Lixisenatide.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Bumetanide Bumetanide The therapeutic efficacy of Lixisenatide can be increased when used in combination with Bumetanide.
Glyburide Glyburide Lixisenatide may increase the hypoglycemic activities of Glyburide.
Glipizide Glipizide Lixisenatide may increase the hypoglycemic activities of Glipizide.
Indapamide Indapamide The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Indapamide.
Amoxicillin Amoxicillin Amoxicillin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Pentoxifylline Pentoxifylline Pentoxifylline may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Pentamidine.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Labetalol Labetalol The therapeutic efficacy of Lixisenatide can be increased when used in combination with Labetalol.
Auranofin Auranofin Auranofin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Leuprolide.
Gemfibrozil Gemfibrozil Gemfibrozil may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Amiodarone Amiodarone The risk or severity of hypoglycemia can be increased when Amiodarone is combined with Lixisenatide.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Buspirone Buspirone Buspirone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ciprofloxacin Ciprofloxacin The therapeutic efficacy of Lixisenatide can be increased when used in combination with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may increase the hypoglycemic activities of Lixisenatide.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Fluoxetine Fluoxetine The risk or severity of hypoglycemia can be increased when Fluoxetine is combined with Lixisenatide.
Nimodipine Nimodipine The risk or severity of hypoglycemia can be increased when Nimodipine is combined with Lixisenatide.
Clozapine Clozapine The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Clozapine.
Estazolam Estazolam Estazolam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ofloxacin Ofloxacin The therapeutic efficacy of Lixisenatide can be increased when used in combination with Ofloxacin.
Didanosine Didanosine Didanosine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Pentostatin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Benazepril Benazepril The risk or severity of hypoglycemia can be increased when Benazepril is combined with Lixisenatide.
Etodolac Etodolac Etodolac may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Felodipine Felodipine The risk or severity of hypoglycemia can be increased when Felodipine is combined with Lixisenatide.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Amlodipine Amlodipine The risk or severity of hypoglycemia can be increased when Amlodipine is combined with Lixisenatide.
Lisinopril Lisinopril Lisinopril may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Sotalol Sotalol The risk or severity of hypoglycemia can be increased when Sotalol is combined with Lixisenatide.
Bisoprolol Bisoprolol The therapeutic efficacy of Lixisenatide can be increased when used in combination with Bisoprolol.
Isradipine Isradipine The risk or severity of hypoglycemia can be increased when Isradipine is combined with Lixisenatide.
Venlafaxine Venlafaxine The risk or severity of hypoglycemia can be increased when Venlafaxine is combined with Lixisenatide.
Fluvoxamine Fluvoxamine The risk or severity of hypoglycemia can be increased when Fluvoxamine is combined with Lixisenatide.
Nefazodone Nefazodone The risk or severity of hypoglycemia can be increased when Nefazodone is combined with Lixisenatide.
Lamotrigine Lamotrigine The risk or severity of hypoglycemia can be increased when Lamotrigine is combined with Lixisenatide.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Tramadol Tramadol Tramadol may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ifosfamide Injection Ifosfamide Injection Ifosfamide may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Nicardipine Nicardipine The risk or severity of hypoglycemia can be increased when Nicardipine is combined with Lixisenatide.
Bupropion Bupropion Bupropion may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Saquinavir Saquinavir The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Saquinavir.
Metformin Metformin The risk or severity of hypoglycemia can be increased when Metformin is combined with Lixisenatide.
Nisoldipine Nisoldipine The risk or severity of hypoglycemia can be increased when Nisoldipine is combined with Lixisenatide.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Acarbose Acarbose The risk or severity of hypoglycemia can be increased when Acarbose is combined with Lixisenatide.
Glimepiride Glimepiride Lixisenatide may increase the hypoglycemic activities of Glimepiride.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Indinavir Indinavir The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Indinavir.
Ritonavir Ritonavir The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Ritonavir.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Clomipramine Clomipramine Clomipramine may decrease the hypoglycemic activities of Lixisenatide.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Topiramate Topiramate Topiramate may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Insulin Lispro Injection Insulin Lispro Injection Lixisenatide may increase the hypoglycemic activities of Insulin lispro.
Pramipexole Pramipexole Pramipexole may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Nelfinavir Nelfinavir The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Nelfinavir.
Carvedilol Carvedilol The therapeutic efficacy of Lixisenatide can be increased when used in combination with Carvedilol.
Nilutamide Nilutamide Nilutamide may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Flutamide Flutamide Flutamide may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Selegiline Selegiline Selegiline may increase the hypoglycemic activities of Lixisenatide.
Sertraline Sertraline The risk or severity of hypoglycemia can be increased when Sertraline is combined with Lixisenatide.
Propafenone Propafenone The therapeutic efficacy of Lixisenatide can be increased when used in combination with Propafenone.
Tamsulosin Tamsulosin The therapeutic efficacy of Lixisenatide can be increased when used in combination with Tamsulosin.
Quetiapine Quetiapine The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Quetiapine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Cetirizine Cetirizine Cetirizine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Paroxetine Paroxetine The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Lixisenatide.
Tolcapone Tolcapone Tolcapone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Citalopram Citalopram The risk or severity of hypoglycemia can be increased when Citalopram is combined with Lixisenatide.
Capecitabine Capecitabine Capecitabine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Abacavir Abacavir Abacavir may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Pioglitazone Pioglitazone The risk or severity of hypoglycemia can be increased when Pioglitazone is combined with Lixisenatide.
Celecoxib Celecoxib The therapeutic efficacy of Lixisenatide can be increased when used in combination with Celecoxib.
Rosiglitazone Rosiglitazone The risk or severity of hypoglycemia can be increased when Rosiglitazone is combined with Lixisenatide.
Tolterodine Tolterodine Tolterodine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may increase the hypoglycemic activities of Lixisenatide.
Nateglinide Nateglinide The risk or severity of hypoglycemia can be increased when Nateglinide is combined with Lixisenatide.
Rabeprazole Rabeprazole Rabeprazole may decrease the excretion rate of Lixisenatide which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists