Mommy's Bliss Gripe Water - Xarelto (Rivaroxaban) Interaction

Interaction Details

Rivaroxaban is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs

Mommy's Bliss Gripe Water contains fennel seed and ginger. Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs as animal research suggests that fennel oil has antithrombotic and antiplatelet effects. Ginger is also thought to have mild blood-thinning effects but this has not been demonstrated conclusively in humans, with mixed results from clinical trials. It is important to note that Mommy's Bliss Gripe Water contains only very small quantities of fennel seed and ginger, and clinically significant interactions with blood-thinning drugs are thought to be quite low.

Interaction Rating

Likelihood of Occurrence

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Pharmacist Analysis

Depending on the dose of Mommy's Bliss Gripe Water given (which depends on age), the amount of ginger and fennel seed ingested by the infant will be between 1mg and 5mg of both.

This small amount is very unlikely to cause a clinically significant interaction with any other drug that thins the blood, but it is important to be aware of it regardless.

References

• Effect of onion and ginger consumption on platelet thromboxane production in humans. PubMed
• The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. PubMed
• [Oral anticoagulants and medicinal plants. An emerging interaction]. PubMed
• Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. PubMed
  

Interaction Details

Rivaroxaban is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates

Mommy's Bliss Gripe Water contains fennel seed. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4. However, this has only been seen in vitro (i.e., in a lab setting) and has not been reported in humans. Additionally, the amount of fennel seed contained in Mommy's Bliss Gripe water is very low, and clinically significant interactions here are thought to be unlikely.

Interaction Rating

Likelihood of Occurrence

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Pharmacist Analysis

Depending on the dose of Mommy's Bliss Gripe Water given (which depends on age), the amount of fennel seed ingested by the infant will be between 1mg and 5mg.

This small amount is very unlikely to cause a clinically significant interaction with any other drug that is metabolized via CYP3A4.

Nevertheless, the theoretical interaction is that fennel, by decreasing the activity of this enzyme, could increase the concentrations of drugs metabolized by it.

The interaction is important to be aware of but will likely not cause any issues.

References

• Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. PubMed
• Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator. PubMed

Rivaroxaban Overview

• Rivaroxaban is used to treat deep vein thrombosis (DVT; a blood clot, usually in the leg) and pulmonary embolism (PE; a blood clot in the lung) in adults. Rivaroxaban is also used to prevent DVT and PE from happening again after initial treatment is completed in adults. It is also used to help prevent strokes or serious blood clots in adults who have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in the body, and possibly causing strokes) that is not caused by heart valve disease. Rivaroxaban is also used to prevent DVT and PE in adults who are having hip replacement or knee replacement surgery or in people who are hospitalized for serious illnesses and are at risk of developing a clot due to decreased ability to move around or other risk factors. It is also used along with aspirin to lower the risk of a heart attack, stroke, or death in adults with coronary artery disease (narrowing of the blood vessels that supply blood to the heart) or peripheral arterial disease (poor circulation in the blood vessels that supply blood to the arms and legs). Rivaroxaban is also used to treat and prevent DVT and PE from happening again in children and certain infants who have received at least 5 days of initial anticoagulation (blood thinner) treatment. It is also used to prevent DVT and PE after heart surgery in children 2 years of age or older who have congenital heart disease (abnormality in the heart that develops before birth). Rivaroxaban is in a class of medications called factor Xa inhibitors. It works by blocking the action of a certain natural substance that helps blood clots to form.

Mommy's Bliss Gripe Water - More Interactions

Mommy's Bliss Gripe Water interacts with 788 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.