Drug & supplement interaction

Mommy's Bliss Gripe Water + Risperidone

Risperidone brand names: Risperdal, Perseris.

Minor Interaction
Medically reviewed by · Updated March 2023
The bottom line Minor

Mommy's Bliss Gripe Water has a minor interaction with Risperidone. Mommy's Bliss Gripe Water contains fennel seed.

Read the full interaction report
SeverityMinor
LikelihoodUnlikely
EvidenceC
What do Severity, Likelihood & Evidence mean?
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Interaction report

Mommy's Bliss Gripe Water and Risperidone

Here is the interaction we found between these two, with the evidence behind it.

Minor

Cytochrome P450 3A4 (Cyp3A4) Substrates

Why this applies to Risperidone

Risperidone falls under Cytochrome P450 3A4 (Cyp3A4) Substrates — the group Mommy's Bliss Gripe Water interacts with.

Mommy's Bliss Gripe Water contains fennel seed. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4. However, this has only been seen in vitro (i.e., in a lab setting) and has not been reported in humans. Additionally, the amount of fennel seed contained in Mommy's Bliss Gripe water is very low, and clinically significant interactions here are thought to be unlikely.
Severity Minor Likelihood Unlikely Evidence C

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: the fennel in this gripe water can, at least in a lab dish, slow down an enzyme called CYP3A4. Your body uses that enzyme to help break down risperidone. In theory, blocking it could let risperidone build up a bit, which might mean more of its usual effects like drowsiness, dizziness, low blood pressure when standing, or restlessness.

The reassuring part is that this has only been seen in a test tube, never in real people, and the amount of fennel in gripe water is tiny. So a meaningful interaction here is considered unlikely. Since risperidone is often used in kids, I'd still loop in your pediatrician or pharmacist before combining the two, just to be safe.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Mommy's Bliss Gripe Water Also Interacts With Other Medications

Mommy's Bliss Gripe Water has 811 minor known drug interactions in our database — the Risperidone one above is one of them. If you take anything else, check it against the full list below.

Minor 811 No known interaction 2,019 (incl. Risperidone)
Taking anything else?

Check Another of Your Medications Against Mommy's Bliss Gripe Water

Covers the 2,830 medications we’ve checked against Mommy's Bliss Gripe Water. Pick one to open its full report.

From our Q&A

Questions About Mommy's Bliss Gripe Water or Risperidone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Mommy's Bliss Gripe Water or Risperidone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Risperidone

This page covers Mommy's Bliss Gripe Water only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Risperidone page lists 199 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 11 major · 147 moderate · 41 minor.

From our pharmacist’s overview on the Risperidone page

“Someone taking risperidone (Risperdal, Perseris) for schizophrenia or bipolar disorder depends on a steady blood level to stay well, and this list calls for genuine care, starting with its eleven major-rated entries. Most of the 199 ingredients can shift that level, because risperidone is cleared by liver enzymes that a long roster of…”

Reviewed by 2 · Jul 18, 2026

Open the Risperidone interaction page

How much people look this up

Where Mommy's Bliss Gripe Water and Risperidone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mommy's Bliss Gripe Water
Steady interest

#795 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Risperidone
Steady interest

#1,784 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Mommy's Bliss Gripe Water

What is Mommy's Bliss Gripe Water?

Mommy's Bliss Gripe Water
  • Infant colic
  • Gas and bloating
  • Hiccups
  • Fussiness after feeding
  • General tummy discomfort

Mommy's Bliss Gripe Water is a sugar-free, alcohol-free liquid made with fennel and ginger that parents use to soothe gassy, colicky, or fussy babies. Strong scientific proof that it works is limited, and most relief reported is anecdotal. Always talk to your pediatrician before giving any supplement to an infant.

Read the full Mommy's Bliss Gripe Water monograph & all interactions
Medication

About Risperidone

What Is Risperidone Used For?

Brand names: Risperdal, Perseris

Risperidone treats schizophrenia and bipolar I disorder. Oral risperidone (tablets, orally disintegrating tablets and oral solution) treats acute manic or mixed episodes of bipolar I disorder, alone or added to lithium or valproate.

Oral risperidone is also used for irritability linked to autistic disorder in children and adolescents. Long-acting injections (Uzedy, Perseris, Risperdal Consta, Rykindo and generic extended-release injectables) are used for schizophrenia. Uzedy, Risperdal Consta, Rykindo and the generic injectables are also used for maintenance treatment of bipolar I disorder. Perseris is labeled for schizophrenia in adults only.

See full Risperidone drug information
Keep checking

Other Drugs & Mommy's Bliss Gripe Water

Browse every other medication we’ve checked against Mommy's Bliss Gripe Water — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
811Minor
2,018No known interaction
811 Minor 2,018 No interaction
Minor

811 interactions

Showing 60 of 811 minor interactions — see all 811 on the Mommy's Bliss Gripe Water page.

No interaction 2,018 drugs checked — show the list

We also checked Mommy's Bliss Gripe Water against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,018 medications checked with no known interaction — see the full Mommy's Bliss Gripe Water list.

See the full Mommy's Bliss Gripe Water interactions page
See every supplement checked against Risperidone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Mommy's Bliss Gripe Water monograph › Uses, safety, and every drug interaction in one place Risperidone supplement interactions › Every supplement checked against Risperidone, ranked by severity Risperidone drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Mommy's Bliss Gripe Water and Risperidone Together: Common Questions

Can you take Mommy's Bliss Gripe Water with Risperidone?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Mommy's Bliss Gripe Water and Risperidone interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Risperidone and Mommy's Bliss Gripe Water?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.