Drug & supplement interaction

Canadian Fleabane + Acetaminophen, Ibuprofen

Acetaminophen, Ibuprofen brand name: Combogesic.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Canadian Fleabane has a moderate interaction with Acetaminophen, Ibuprofen. Theoretically, Canadian fleabane might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Canadian Fleabane and Acetaminophen, Ibuprofen

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Acetaminophen, Ibuprofen

Acetaminophen, Ibuprofen falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Canadian Fleabane interacts with.

Theoretically, Canadian fleabane might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs. Canadian fleabane has been shown to inhibit platelet aggregation in vitro.
Some anticoagulant/antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to know about Combogesic: the ibuprofen part already has a mild blood-thinning effect of its own because it dampens how your platelets stick together. Canadian Fleabane, at least in lab dish studies, seems to do something similar. So in theory, pairing them could add up and make it a little easier to bruise or bleed, think nosebleeds, bleeding gums, or stomach upset that lingers.

I'll be honest, this is a theoretical concern, based on how these things behave in test tubes rather than real people. The acetaminophen side isn't really part of this. Still, if you take Combogesic regularly or have any bleeding risk, it's worth a quick chat with your pharmacist or doctor before adding the supplement.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Saluk-Juszczak J, Olas B, Pawlaczyk I, Gancarz R, Wachowicz B. Effects of the extract from Conyza canadensis on human blood platelet aggregation. Gen Physiol Biophys 2007;26(2):150-2.
  2. Olas B, Saluk-Juszczak J, Pawlaczyk I, et al. Antioxidant and antiaggregatory effects of an extract from Conyza canadensis on blood platelets in vitro. Platelets 2006;17(6):354-60.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Canadian Fleabane Also Interacts With Other Medications

Canadian Fleabane has 121 moderate known drug interactions in our database — the Acetaminophen, Ibuprofen one above is one of them. If you take anything else, check it against the full list below.

Moderate 121 No known interaction 2,709 (incl. Acetaminophen, Ibuprofen)
Taking anything else?

Check Another of Your Medications Against Canadian Fleabane

Covers the 2,830 medications we’ve checked against Canadian Fleabane. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Acetaminophen, Ibuprofen

This page covers Canadian Fleabane only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Ibuprofen page lists 342 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 290 moderate · 45 minor.

From our pharmacist’s overview on the Acetaminophen, Ibuprofen page

“Combogesic pairs acetaminophen with ibuprofen, so it inherits the vulnerabilities of both drugs, and its supplement list deserves real attention before you add anything to it. Of the 342 ingredients on file, 7 carry a major rating, and those are the ones to understand first.”

Reviewed by 2 · Jul 18, 2026

Open the Acetaminophen, Ibuprofen interaction page

How much people look this up

Where Canadian Fleabane and Acetaminophen, Ibuprofen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Canadian Fleabane
Steady interest

#731 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetaminophen, Ibuprofen
Top 10%

#207 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Canadian Fleabane

What is Canadian Fleabane?

  • Diarrhea
  • Minor bleeding
  • Urinary complaints
  • Digestive upset
  • Sore throat and inflammation

Canadian Fleabane is a common North American weed used in traditional medicine for diarrhea, minor bleeding, and urinary issues, but high-quality human studies are lacking. Because its safety has not been well studied, it is best to talk with your pharmacist or doctor before using it, and to avoid it during pregnancy and breastfeeding.

Read the full Canadian Fleabane monograph & all interactions
Keep checking

Other Drugs & Canadian Fleabane

Browse every other medication we’ve checked against Canadian Fleabane — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
121Moderate
0Minor
2,708No known interaction
121 Moderate 2,708 No interaction
Moderate

121 interactions

Showing 60 of 121 moderate interactions — see all 121 on the Canadian Fleabane page.

No interaction 2,708 drugs checked — show the list

We also checked Canadian Fleabane against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,708 medications checked with no known interaction — see the full Canadian Fleabane list.

See the full Canadian Fleabane interactions page
See every supplement checked against Acetaminophen, Ibuprofen, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Canadian Fleabane monograph › Uses, safety, and every drug interaction in one place Acetaminophen, Ibuprofen supplement interactions › Every supplement checked against Acetaminophen, Ibuprofen, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Canadian Fleabane and Acetaminophen, Ibuprofen Together: Common Questions

Can you take Canadian Fleabane with Acetaminophen, Ibuprofen?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Canadian Fleabane and Acetaminophen, Ibuprofen interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Acetaminophen, Ibuprofen and Canadian Fleabane?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.