Drug & supplement interaction

Bridelia + Acetaminophen, Ibuprofen

Acetaminophen, Ibuprofen brand name: Combogesic.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Bridelia has a moderate interaction with Acetaminophen, Ibuprofen. In animals, orally administered extracts of Bridelia ferruginea stem bark inhibit ADP/adrenaline-induced thrombosis by approximately 62%.Theoretically, Bridelia might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Bridelia and Acetaminophen, Ibuprofen

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Acetaminophen, Ibuprofen

Acetaminophen, Ibuprofen falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Bridelia interacts with.

In animals, orally administered extracts of Bridelia ferruginea stem bark inhibit ADP/adrenaline-induced thrombosis by approximately 62%.Theoretically, Bridelia might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Some of these drugs include aspirin, clopidogrel (Plavix), nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Combogesic combines two pain relievers, and the ibuprofen half is the part that matters here. Ibuprofen is an NSAID, and like aspirin it already nudges your blood toward being a little slower to clot. In animal studies, Bridelia ferruginea seemed to reduce clot formation too. So putting the two together could, in theory, add up and raise your chance of bleeding or bruising.

Keep in mind this is theoretical, based only on animal data, not human studies. Still, watch for warning signs like easy bruising, nosebleeds, dark or bloody stools, or stomach upset, which ibuprofen can also cause on its own. If you take blood thinners or use Combogesic regularly, please check with your pharmacist or doctor before adding Bridelia.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Olajide, O. A. Investigation of the effects of selected medicinal plants on experimental thrombosis. Phytother Res 1999;13(3):231-232. DOI

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Bridelia Also Interacts With Other Medications

Bridelia has 329 moderate known drug interactions in our database — the Acetaminophen, Ibuprofen one above is one of them. If you take anything else, check it against the full list below.

Moderate 329 No known interaction 2,501 (incl. Acetaminophen, Ibuprofen)
Taking anything else?

Check Another of Your Medications Against Bridelia

Covers the 2,830 medications we’ve checked against Bridelia. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Acetaminophen, Ibuprofen

This page covers Bridelia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Ibuprofen page lists 342 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 290 moderate · 45 minor.

From our pharmacist’s overview on the Acetaminophen, Ibuprofen page

“Combogesic pairs acetaminophen with ibuprofen, so it inherits the vulnerabilities of both drugs, and its supplement list deserves real attention before you add anything to it. Of the 342 ingredients on file, 7 carry a major rating, and those are the ones to understand first.”

Reviewed by 2 · Jul 18, 2026

Open the Acetaminophen, Ibuprofen interaction page

How much people look this up

Where Bridelia and Acetaminophen, Ibuprofen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bridelia
Top half

#640 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetaminophen, Ibuprofen
Top 10%

#207 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Bridelia

What is Bridelia?

  • Blood sugar support
  • Digestive complaints and diarrhea
  • Wound care and skin conditions
  • Antimicrobial use
  • Mouth and gum care (traditional chewing stick)

Bridelia is a group of tropical plants, with Bridelia ferruginea widely used in traditional African medicine for diabetes, infections, and digestive problems. Scientific evidence is mostly limited to laboratory and animal studies, so its benefits and safety in people are not well established. Talk to a pharmacist or doctor before using it, especially if you take other medicines or have a health condition.

Read the full Bridelia monograph & all interactions
Keep checking

Other Drugs & Bridelia

Browse every other medication we’ve checked against Bridelia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
329Moderate
0Minor
2,500No known interaction
329 Moderate 2,500 No interaction
Moderate

329 interactions

Showing 60 of 329 moderate interactions — see all 329 on the Bridelia page.

No interaction 2,500 drugs checked — show the list

We also checked Bridelia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,500 medications checked with no known interaction — see the full Bridelia list.

See the full Bridelia interactions page
See every supplement checked against Acetaminophen, Ibuprofen, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Bridelia monograph › Uses, safety, and every drug interaction in one place Acetaminophen, Ibuprofen supplement interactions › Every supplement checked against Acetaminophen, Ibuprofen, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Bridelia and Acetaminophen, Ibuprofen Together: Common Questions

Can you take Bridelia with Acetaminophen, Ibuprofen?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Bridelia and Acetaminophen, Ibuprofen interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Acetaminophen, Ibuprofen and Bridelia?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.