Drug & supplement interaction

Jackfruit + Diroximel Fumarate

Diroximel Fumarate brand name: Vumerity.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Jackfruit and Diroximel Fumarate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Diroximel Fumarate states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Jackfruit and Diroximel Fumarate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diroximel Fumarate and Jackfruit in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Jackfruit safety at a glance

Jackfruit overall Generally safe The ripe fruit is widely eaten and generally safe as a food for most people.
Pregnancy Use caution The fruit as food is likely fine, but concentrated supplements lack safety data and should be avoided unless approved by your doctor.
Breastfeeding Use caution Eating the fruit is likely fine, but there is not enough safety data on medicinal jackfruit products while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diroximel Fumarate and Jackfruit? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Diroximel Fumarate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Diroximel Fumarate is filed under 3 classifications — immunosuppressants, hepatotoxic drugs, oral drugs. Jackfruit has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and cns depressants (moderate) — and none of Diroximel Fumarate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Jackfruit Does Interact With Other Medications

Jackfruit has 437 moderate known drug interactions in our database — Diroximel Fumarate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 437 No known interaction 2,393 (incl. Diroximel Fumarate)
Taking anything else?

Check Another of Your Medications Against Jackfruit

Covers the 2,830 medications we’ve checked against Jackfruit. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Jackfruit and Diroximel Fumarate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A severe allergic reaction Worth acting on Additional detail

    Jackfruit

    “Orally, the fruit of jackfruit might cause serious allergic reactions, including anaphylaxis, in sensitive individuals. In one case report, a 34-year-old female developed anaphylaxis with symptoms of cough, dyspnea, facial swelling, and urticaria after eating 10 pieces of dried jackfruit. There is speculation that latex allergy might result in a cross-reactivity to jackfruit.”

    Jackfruit · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    2 sources cited
    1. 98378. Wongrakpanich S, Klaewsongkram J, Chantaphakul H, Ruxrungtham K. Jackfruit anaphylaxis in a latex allergic patient. Asian Pac J Allergy Immunol. 2015;33(1):65-8.
    2. 112050. Jalil M, Hostoffer R, Wu SS. Jackfruit Anaphylaxis in a Latex Allergic Non-Healthcare Worker. Allergy Rhinol (Providence) 2021;12:21526567211009195. PubMed

    Diroximel Fumarate

    Listed in the ADVERSE REACTIONS section of the FDA label for Diroximel Fumarate. Read the label on DailyMed ›

Reported for Jackfruit but not commonly for Diroximel Fumarate: an allergic reaction, hives, swelling and shortness of breath.

Effects for Diroximel Fumarate come from the ADVERSE REACTIONS section of its FDA label; effects for Jackfruit come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 11,848 voluntary FDA FAERS reports for Diroximel Fumarate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Diroximel Fumarate Products Have a Food Rule — Jackfruit Should Not Break It

At least one FDA label for a product containing Diroximel Fumarate says to take it with food. If you take Jackfruit on an empty stomach out of habit, keep them separate — and take Diroximel Fumarate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Diroximel Fumarate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

If taken with food, avoid a high-fat, high-calorie meal/snack; the meal/snack should contain no more than 700 calories and no more than 30 g fat [see Warnings and Precautions ( 5.6 ) and Clinical Pharmacology ( 12.3 )] .

From the Dosage and Administration section of the FDA label we read for Diroximel Fumarate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Diroximel Fumarate

This page covers Jackfruit only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diroximel Fumarate page lists 106 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Active Hexose Correlated Compound (ahcc) (moderate).

By severity: 4 major · 92 moderate · 10 minor.

From our pharmacist’s overview on the Diroximel Fumarate page

“Diroximel fumarate (Vumerity) treats relapsing multiple sclerosis by quieting an overactive immune system, and I read its interaction list with real seriousness. Four of the 106 entries rate major, and none are exotic.”

Reviewed by 2 · Jul 18, 2026

Open the Diroximel Fumarate interaction page

How much people look this up

Where Jackfruit and Diroximel Fumarate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jackfruit
Top half

#572 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diroximel Fumarate
Top 25%

#488 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jackfruit reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Jackfruit and Diroximel Fumarate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Jackfruit

What is Jackfruit?

Jackfruit
  • General nutrition
  • Blood sugar support
  • Digestive health (fiber)
  • Antioxidant support
  • Wound care (traditional, latex/leaves)

Jackfruit is a large tropical fruit that is nutritious and safe to eat as a food, offering fiber, vitamin C, potassium, and antioxidants. While its leaves, seeds, and other parts are used in traditional medicine for things like blood sugar and digestion, strong human evidence for these supplement uses is limited. Talk to your pharmacist or doctor before using concentrated jackfruit products for a health condition.

Artocarpus heterophyllus · Moraceae · Fruit, seeds, leaves, bark, roots, and latex · Fresh or canned fruit, dried fruit, flour, seeds, capsules, powder, and leaf or bark extracts

An interaction check asks whether these two react with each other — it does not ask whether Jackfruit is a good idea for someone in your situation. Here is what our Jackfruit record says about it on its own.

Jackfruit: dosing

There is no established standard dose for jackfruit as a supplement. As a food, you can simply enjoy it as part of a balanced diet.For capsules, powders, or extracts, no proven medicinal dose has been set in research, so follow the directions on the product label.

From our Jackfruit monograph — the full record covers uses, side effects and every documented interaction.

Read the full Jackfruit monograph & all interactions
Medication

About Diroximel Fumarate

What Is Diroximel Fumarate Used For?

Brand name: Vumerity

Vumerity (diroximel fumarate) is used to treat relapsing forms of multiple sclerosis (MS) in adults. This includes three specific types: clinically isolated syndrome (a first MS episode), relapsing-remitting MS (the most common pattern of flares and recovery), and active secondary progressive MS (a later stage where disability gradually worsens but relapses still occur).

Most-Reported Side Effects for Diroximel Fumarate

From FAERS, the FDA’s public side-effect reporting system (11,848 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Flushing 1,611 reports
Multiple sclerosis 1,099 reports
Multiple sclerosis relapse 973 reports
Diarrhea 873 reports
Fatigue 781 reports
See full Diroximel Fumarate drug information
Keep checking

Other Drugs & Jackfruit

Browse every other medication we’ve checked against Jackfruit — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
437Moderate
0Minor
2,392No known interaction
437 Moderate 2,392 No interaction
Moderate

437 interactions

Showing 60 of 437 moderate interactions — see all 437 on the Jackfruit page.

No interaction 2,392 drugs checked — show the list

We also checked Jackfruit against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,392 medications checked with no known interaction — see the full Jackfruit list.

See the full Jackfruit interactions page
See every supplement checked against Diroximel Fumarate, ranked by severity
Evidence & sources

Jackfruit References

The 7 references that drive our Jackfruit monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Fernando MR, Wickramasinghe N, Thabrew MI, Ariyananda PL, Karunanayake EH. Effect of Artocarpus heterophyllus and Asteracanthus longifolia on glucose tolerance in normal human subjects and in maturity-onset diabetic patients. J Ethnopharmacol 1991;31(3):2 PubMed
  2. Ratnasooriya WD, Jayakody JR. Artocarpus heterophyllus seeds inhibits sexual competence but not fertility of male rats. Indian J Exp Biol 2002;40(3):304-308.
  3. Siritapetawee J, Thammasirirak S. Purification and characterization of a heteromultimeric glycoprotein from Artocarpus heterophylluslatex with an inhibitory effect on human blood coagulation. Acta Biochim Pol. 2011;58(4):521-8.
  4. Siritapetawee J, Thumanu K, Sojikul P, Thammasirirak S. A novel serine protease with human fibrino(geno)lytic activities from Artocarpus heterophylluslatex. Biochim Biophys Acta. 2012;1824(7):907-12.
  5. Wongrakpanich S, Klaewsongkram J, Chantaphakul H, Ruxrungtham K. Jackfruit anaphylaxis in a latex allergic patient. Asian Pac J Allergy Immunol. 2015;33(1):65-8.
  6. Jalil M, Hostoffer R, Wu SS. Jackfruit Anaphylaxis in a Latex Allergic Non-Healthcare Worker. Allergy Rhinol (Providence) 2021;12:21526567211009195. PubMed
  7. Rao AG, Naik KS, Unnikrishnan AG, Joseph J. Efficacy of green jackfruit flour as a medical nutrition therapy replacing rice or wheat in patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study. Nutr Diabetes 2021;11(1): PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Jackfruit and Diroximel Fumarate Together: Common Questions

Is it safe to take Jackfruit with Diroximel Fumarate?
We do not list a known interaction between Jackfruit and Diroximel Fumarate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Jackfruit and Diroximel Fumarate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Jackfruit and Diroximel Fumarate at the same time of day?
At least one FDA label for a product containing Diroximel Fumarate says to take it with food. If you take Jackfruit on an empty stomach out of habit, keep them separate and take Diroximel Fumarate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Diroximel Fumarate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Jackfruit and Diroximel Fumarate combination checked?
Interactions in our licensed database are recorded against drug classes. Diroximel Fumarate is filed under 3 classifications, and Jackfruit has documented interactions with 3 drug classes — none of Diroximel Fumarate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Jackfruit interact with any other medications?
Yes. Jackfruit has 437 documented drug interactions in our database — Diroximel Fumarate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Diroximel Fumarate interact with any supplements?
Yes. Diroximel Fumarate has documented interactions with 106 supplements in our database — Jackfruit is not one of them. The Diroximel Fumarate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Jackfruit monograph Uses, safety profile, and every drug interaction in one place Diroximel Fumarate drug information The full plain-English guide to this medication Diroximel Fumarate supplement interactions Every supplement checked against Diroximel Fumarate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diroximel Fumarate and Jackfruit?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.