Drug & supplement interaction

Jackfruit + Fenofibrate

Fenofibrate brand names: Tricor, Fenofibrate, Lipidil Micro, Lipidil Supra, Antara, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Jackfruit and Fenofibrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Jackfruit and Fenofibrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fenofibrate and Jackfruit in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Jackfruit safety at a glance

Jackfruit overall Generally safe The ripe fruit is widely eaten and generally safe as a food for most people.
Pregnancy Use caution The fruit as food is likely fine, but concentrated supplements lack safety data and should be avoided unless approved by your doctor.
Breastfeeding Use caution Eating the fruit is likely fine, but there is not enough safety data on medicinal jackfruit products while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fenofibrate and Jackfruit? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Fenofibrate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Fenofibrate is filed under 3 classifications — cytochrome p450 2c9 (cyp2c9) inhibitors, hepatotoxic drugs, oral drugs. Jackfruit has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and cns depressants (moderate) — and none of Fenofibrate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Jackfruit Does Interact With Other Medications

Jackfruit has 437 moderate known drug interactions in our database — Fenofibrate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 437 No known interaction 2,393 (incl. Fenofibrate)
Taking anything else?

Check Another of Your Medications Against Jackfruit

Covers the 2,830 medications we’ve checked against Jackfruit. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Jackfruit and Fenofibrate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Hives / An allergic reaction Worth acting on Additional detail

    Jackfruit

    “Orally, the fruit of jackfruit might cause serious allergic reactions, including anaphylaxis, in sensitive individuals. In one case report, a 34-year-old female developed anaphylaxis with symptoms of cough, dyspnea, facial swelling, and urticaria after eating 10 pieces of dried jackfruit. There is speculation that latex allergy might result in a cross-reactivity to jackfruit.”

    Jackfruit · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    2 sources cited
    1. 98378. Wongrakpanich S, Klaewsongkram J, Chantaphakul H, Ruxrungtham K. Jackfruit anaphylaxis in a latex allergic patient. Asian Pac J Allergy Immunol. 2015;33(1):65-8.
    2. 112050. Jalil M, Hostoffer R, Wu SS. Jackfruit Anaphylaxis in a Latex Allergic Non-Healthcare Worker. Allergy Rhinol (Providence) 2021;12:21526567211009195. PubMed

    Fenofibrate

    Listed in the ADVERSE REACTIONS section of the FDA label for Fenofibrate. Read the label on DailyMed ›

Reported for Jackfruit but not commonly for Fenofibrate: a severe allergic reaction, swelling, shortness of breath and cough.

Effects for Fenofibrate come from the ADVERSE REACTIONS section of its FDA label; effects for Jackfruit come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 35,249 voluntary FDA FAERS reports for Fenofibrate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Fenofibrate Is Prescribed For, and What Jackfruit Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Fenofibrate is a prescription medicine with approved uses on its FDA label. Jackfruit is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Fenofibrate is prescribed for: Fenofibrate is used alongside a cholesterol-lowering diet in adults to improve abnormal lipid levels. Tricor (tablet) and fenofibrate tablets are indicated to lower LDL cholesterol (bad cholesterol), total cholesterol, triglycerides, and apolipoprotein B, and to raise HDL cholesterol (good cholesterol) in adults with primary hypercholesterolemia (high cholesterol) or mixed dyslipidemia (mixed abnormal lipid levels). They are also used to treat severe hypertriglyceridemia (very high triglycerides). Antara and Lipofen (capsules) are indicated to reduce triglyceride levels in adults with severe hypertriglyceridemia, and to lower LDL cholesterol in adults with primary hyperlipidemia when other recommended LDL-lowering therapies cannot be used.

Read the rest of what Fenofibrate is prescribed for

Fenofibrate has not been shown to reduce heart attacks or cardiovascular deaths in patients with type 2 diabetes.

Jackfruit has been studied for:

  • Diabetes studied, not established Jackfruit has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Jackfruit for diabetes

    Small clinical studies suggest that oral jackfruit flour or leaf extract might improve glycemic control in patients with diabetes.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Fenofibrate on your own; if you are taking Jackfruit for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Fenofibrate

This page covers Jackfruit only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fenofibrate page lists 59 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Ashwagandha (moderate).

By severity: 4 major · 46 moderate · 9 minor.

From our pharmacist’s overview on the Fenofibrate page

“Fenofibrate (Tricor, Antara) is a cholesterol and triglyceride medicine that can strain the liver on its own, so this list of 59 supplements deserves genuine care rather than a shrug. Most of it, 38 ingredients, involves herbs that also stress the liver, ashwagandha among them, and stacking those effects is the risk that matters most h…”

Reviewed by 2 · Jul 18, 2026

Open the Fenofibrate interaction page

How much people look this up

Where Jackfruit and Fenofibrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jackfruit
Top half

#627 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fenofibrate
Steady interest

#1,581 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jackfruit reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Jackfruit and Fenofibrate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Jackfruit

What is Jackfruit?

Jackfruit
  • General nutrition
  • Blood sugar support
  • Digestive health (fiber)
  • Antioxidant support
  • Wound care (traditional, latex/leaves)

Jackfruit is a large tropical fruit that is nutritious and safe to eat as a food, offering fiber, vitamin C, potassium, and antioxidants. While its leaves, seeds, and other parts are used in traditional medicine for things like blood sugar and digestion, strong human evidence for these supplement uses is limited. Talk to your pharmacist or doctor before using concentrated jackfruit products for a health condition.

Artocarpus heterophyllus · Moraceae · Fruit, seeds, leaves, bark, roots, and latex · Fresh or canned fruit, dried fruit, flour, seeds, capsules, powder, and leaf or bark extracts

An interaction check asks whether these two react with each other — it does not ask whether Jackfruit is a good idea for someone in your situation. Here is what our Jackfruit record says about it on its own.

Jackfruit: dosing

There is no established standard dose for jackfruit as a supplement. As a food, you can simply enjoy it as part of a balanced diet.For capsules, powders, or extracts, no proven medicinal dose has been set in research, so follow the directions on the product label.

From our Jackfruit monograph — the full record covers uses, side effects and every documented interaction.

Read the full Jackfruit monograph & all interactions
Medication

About Fenofibrate

What Is Fenofibrate Used For?

Brand names: Tricor, Fenofibrate, Lipidil Micro, Lipidil Supra, Antara, Lofibra, Triglide, Lipidil EZ

Fenofibrate is used alongside a cholesterol-lowering diet in adults to improve abnormal lipid levels. Tricor (tablet) and fenofibrate tablets are indicated to lower LDL cholesterol (bad cholesterol), total cholesterol, triglycerides, and apolipoprotein B, and to raise HDL cholesterol (good cholesterol) in adults with primary hypercholesterolemia (high cholesterol) or mixed dyslipidemia (mixed abnormal lipid levels). They are also used to treat severe hypertriglyceridemia (very high triglycerides).

Antara and Lipofen (capsules) are indicated to reduce triglyceride levels in adults with severe hypertriglyceridemia, and to lower LDL cholesterol in adults with primary hyperlipidemia when other recommended LDL-lowering therapies cannot be used. Fenofibrate has not been shown to reduce heart attacks or cardiovascular deaths in patients with type 2 diabetes.

Most-Reported Side Effects for Fenofibrate

From FAERS, the FDA’s public side-effect reporting system (35,249 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 2,173 reports
Diarrhea 2,103 reports
Nausea 2,045 reports
Headache 1,571 reports
Dyspnea 1,527 reports
See full Fenofibrate drug information
Keep checking

Other Drugs & Jackfruit

Browse every other medication we’ve checked against Jackfruit — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
437Moderate
0Minor
2,392No known interaction
437 Moderate 2,392 No interaction
Moderate

437 interactions

Showing 60 of 437 moderate interactions — see all 437 on the Jackfruit page.

No interaction 2,392 drugs checked — show the list

We also checked Jackfruit against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,392 medications checked with no known interaction — see the full Jackfruit list.

See the full Jackfruit interactions page
See every supplement checked against Fenofibrate, ranked by severity
Evidence & sources

Jackfruit References

The 7 references that drive our Jackfruit monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Fernando MR, Wickramasinghe N, Thabrew MI, Ariyananda PL, Karunanayake EH. Effect of Artocarpus heterophyllus and Asteracanthus longifolia on glucose tolerance in normal human subjects and in maturity-onset diabetic patients. J Ethnopharmacol 1991;31(3):2 PubMed
  2. Ratnasooriya WD, Jayakody JR. Artocarpus heterophyllus seeds inhibits sexual competence but not fertility of male rats. Indian J Exp Biol 2002;40(3):304-308.
  3. Siritapetawee J, Thammasirirak S. Purification and characterization of a heteromultimeric glycoprotein from Artocarpus heterophylluslatex with an inhibitory effect on human blood coagulation. Acta Biochim Pol. 2011;58(4):521-8.
  4. Siritapetawee J, Thumanu K, Sojikul P, Thammasirirak S. A novel serine protease with human fibrino(geno)lytic activities from Artocarpus heterophylluslatex. Biochim Biophys Acta. 2012;1824(7):907-12.
  5. Wongrakpanich S, Klaewsongkram J, Chantaphakul H, Ruxrungtham K. Jackfruit anaphylaxis in a latex allergic patient. Asian Pac J Allergy Immunol. 2015;33(1):65-8.
  6. Jalil M, Hostoffer R, Wu SS. Jackfruit Anaphylaxis in a Latex Allergic Non-Healthcare Worker. Allergy Rhinol (Providence) 2021;12:21526567211009195. PubMed
  7. Rao AG, Naik KS, Unnikrishnan AG, Joseph J. Efficacy of green jackfruit flour as a medical nutrition therapy replacing rice or wheat in patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study. Nutr Diabetes 2021;11(1): PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Jackfruit and Fenofibrate Together: Common Questions

Is it safe to take Jackfruit with Fenofibrate?
We do not list a known interaction between Jackfruit and Fenofibrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Jackfruit and Fenofibrate have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Jackfruit and Fenofibrate used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Jackfruit in each. That is a conversation for your prescriber, especially if Fenofibrate is being adjusted to a target.
How was the Jackfruit and Fenofibrate combination checked?
Interactions in our licensed database are recorded against drug classes. Fenofibrate is filed under 3 classifications, and Jackfruit has documented interactions with 3 drug classes — none of Fenofibrate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Jackfruit interact with any other medications?
Yes. Jackfruit has 437 documented drug interactions in our database — Fenofibrate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Fenofibrate interact with any supplements?
Yes. Fenofibrate has documented interactions with 59 supplements in our database — Jackfruit is not one of them. The Fenofibrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Jackfruit monograph Uses, safety profile, and every drug interaction in one place Fenofibrate drug information The full plain-English guide to this medication Fenofibrate supplement interactions Every supplement checked against Fenofibrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fenofibrate and Jackfruit?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.