Drug & supplement interaction

Jackfruit + Fostemsavir Tromethamine

Fostemsavir Tromethamine brand name: Rukobia.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Jackfruit and Fostemsavir Tromethamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Jackfruit and Fostemsavir Tromethamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fostemsavir Tromethamine and Jackfruit in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Jackfruit safety at a glance

Jackfruit overall Generally safe The ripe fruit is widely eaten and generally safe as a food for most people.
Pregnancy Use caution The fruit as food is likely fine, but concentrated supplements lack safety data and should be avoided unless approved by your doctor.
Breastfeeding Use caution Eating the fruit is likely fine, but there is not enough safety data on medicinal jackfruit products while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fostemsavir Tromethamine and Jackfruit? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Fostemsavir Tromethamine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Fostemsavir Tromethamine is filed under 3 classifications — qt interval-prolonging drugs, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Jackfruit has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and cns depressants (moderate) — and none of Fostemsavir Tromethamine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Jackfruit Does Interact With Other Medications

Jackfruit has 437 moderate known drug interactions in our database — Fostemsavir Tromethamine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 437 No known interaction 2,393 (incl. Fostemsavir Tromethamine)
Taking anything else?

Check Another of Your Medications Against Jackfruit

Covers the 2,830 medications we’ve checked against Jackfruit. Pick one to open its full report.

What to actually watch for

What Jackfruit Itself Has Been Linked To

This is not an interaction — nothing below involves Fostemsavir Tromethamine. It is the side-effect record for Jackfruit on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Jackfruit, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Shortness of breath / A severe allergic reaction / Hives / An allergic reaction Worth acting on Additional detail

    “Orally, the fruit of jackfruit might cause serious allergic reactions, including anaphylaxis, in sensitive individuals. In one case report, a 34-year-old female developed anaphylaxis with symptoms of cough, dyspnea, facial swelling, and urticaria after eating 10 pieces of dried jackfruit. There is speculation that latex allergy might result in a cross-reactivity to jackfruit.”

    Jackfruit · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    2 sources cited
    1. 98378. Wongrakpanich S, Klaewsongkram J, Chantaphakul H, Ruxrungtham K. Jackfruit anaphylaxis in a latex allergic patient. Asian Pac J Allergy Immunol. 2015;33(1):65-8.
    2. 112050. Jalil M, Hostoffer R, Wu SS. Jackfruit Anaphylaxis in a Latex Allergic Non-Healthcare Worker. Allergy Rhinol (Providence) 2021;12:21526567211009195. PubMed
  • Cough / Swelling Additional detail

    Recorded for Jackfruit in the same Natural Medicines adverse-effect record shown under Shortness of breath / A severe allergic reaction / Hives / An allergic reaction above.

Everything above comes from the Natural Medicines adverse-effect record for Jackfruit — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Fostemsavir Tromethamine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Fostemsavir Tromethamine column appears here.

Everything else you take

See Every Supplement That Interacts With Fostemsavir Tromethamine

This page covers Jackfruit only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fostemsavir Tromethamine page lists 146 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 98 moderate · 40 minor.

Open the Fostemsavir Tromethamine interaction page

How much people look this up

Where Jackfruit and Fostemsavir Tromethamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jackfruit
Steady interest

#743 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fostemsavir Tromethamine
Steady interest

#2,772 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jackfruit reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Jackfruit and Fostemsavir Tromethamine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Jackfruit

What is Jackfruit?

Jackfruit
  • General nutrition
  • Blood sugar support
  • Digestive health (fiber)
  • Antioxidant support
  • Wound care (traditional, latex/leaves)

Jackfruit is a large tropical fruit that is nutritious and safe to eat as a food, offering fiber, vitamin C, potassium, and antioxidants. While its leaves, seeds, and other parts are used in traditional medicine for things like blood sugar and digestion, strong human evidence for these supplement uses is limited. Talk to your pharmacist or doctor before using concentrated jackfruit products for a health condition.

Artocarpus heterophyllus · Moraceae · Fruit, seeds, leaves, bark, roots, and latex · Fresh or canned fruit, dried fruit, flour, seeds, capsules, powder, and leaf or bark extracts

An interaction check asks whether these two react with each other — it does not ask whether Jackfruit is a good idea for someone in your situation. Here is what our Jackfruit record says about it on its own.

Jackfruit: dosing

There is no established standard dose for jackfruit as a supplement. As a food, you can simply enjoy it as part of a balanced diet.For capsules, powders, or extracts, no proven medicinal dose has been set in research, so follow the directions on the product label.

From our Jackfruit monograph — the full record covers uses, side effects and every documented interaction.

Read the full Jackfruit monograph & all interactions
Medication

About Fostemsavir

What Is Fostemsavir Used For?

Brand name: Rukobia

Rukobia (fostemsavir) is used to treat HIV-1 infection in adults who have tried many other antiretroviral treatments and whose virus is no longer responding — due to resistance, side effects, or safety concerns. It is always used alongside other HIV medicines, not on its own.

Rukobia is specifically intended for heavily treatment-experienced patients with multidrug-resistant HIV-1 who are failing their current regimen. It is not a first-line HIV treatment.

Most-Reported Side Effects for Fostemsavir Tromethamine

From FAERS, the FDA’s public side-effect reporting system (238 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 17 reports
Rash 11 reports
Viral load increased 11 reports
Pathogen resistance 10 reports
Dizziness 9 reports
See full Fostemsavir drug information
Keep checking

Other Drugs & Jackfruit

Browse every other medication we’ve checked against Jackfruit — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
437Moderate
0Minor
2,392No known interaction
437 Moderate 2,392 No interaction
Moderate

437 interactions

Showing 60 of 437 moderate interactions — see all 437 on the Jackfruit page.

No interaction 2,392 drugs checked — show the list

We also checked Jackfruit against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,392 medications checked with no known interaction — see the full Jackfruit list.

See the full Jackfruit interactions page
See every supplement checked against Fostemsavir Tromethamine, ranked by severity
Evidence & sources

Jackfruit References

The 7 references that drive our Jackfruit monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Fernando MR, Wickramasinghe N, Thabrew MI, Ariyananda PL, Karunanayake EH. Effect of Artocarpus heterophyllus and Asteracanthus longifolia on glucose tolerance in normal human subjects and in maturity-onset diabetic patients. J Ethnopharmacol 1991;31(3):2 PubMed
  2. Ratnasooriya WD, Jayakody JR. Artocarpus heterophyllus seeds inhibits sexual competence but not fertility of male rats. Indian J Exp Biol 2002;40(3):304-308.
  3. Siritapetawee J, Thammasirirak S. Purification and characterization of a heteromultimeric glycoprotein from Artocarpus heterophylluslatex with an inhibitory effect on human blood coagulation. Acta Biochim Pol. 2011;58(4):521-8.
  4. Siritapetawee J, Thumanu K, Sojikul P, Thammasirirak S. A novel serine protease with human fibrino(geno)lytic activities from Artocarpus heterophylluslatex. Biochim Biophys Acta. 2012;1824(7):907-12.
  5. Wongrakpanich S, Klaewsongkram J, Chantaphakul H, Ruxrungtham K. Jackfruit anaphylaxis in a latex allergic patient. Asian Pac J Allergy Immunol. 2015;33(1):65-8.
  6. Jalil M, Hostoffer R, Wu SS. Jackfruit Anaphylaxis in a Latex Allergic Non-Healthcare Worker. Allergy Rhinol (Providence) 2021;12:21526567211009195. PubMed
  7. Rao AG, Naik KS, Unnikrishnan AG, Joseph J. Efficacy of green jackfruit flour as a medical nutrition therapy replacing rice or wheat in patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study. Nutr Diabetes 2021;11(1): PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Jackfruit and Fostemsavir Tromethamine Together: Common Questions

Is it safe to take Jackfruit with Fostemsavir Tromethamine?
We do not list a known interaction between Jackfruit and Fostemsavir Tromethamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Jackfruit and Fostemsavir Tromethamine combination checked?
Interactions in our licensed database are recorded against drug classes. Fostemsavir Tromethamine is filed under 3 classifications, and Jackfruit has documented interactions with 3 drug classes — none of Fostemsavir Tromethamine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Jackfruit interact with any other medications?
Yes. Jackfruit has 437 documented drug interactions in our database — Fostemsavir Tromethamine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Fostemsavir Tromethamine interact with any supplements?
Yes. Fostemsavir Tromethamine has documented interactions with 146 supplements in our database — Jackfruit is not one of them. The Fostemsavir Tromethamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Jackfruit monograph Uses, safety profile, and every drug interaction in one place Fostemsavir drug information The full plain-English guide to this medication Fostemsavir Tromethamine supplement interactions Every supplement checked against Fostemsavir Tromethamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fostemsavir Tromethamine and Jackfruit?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.