Jackfruit - Xigduo XR (Dapagliflozin Propanediol, Metformin) Interaction
Herbal: Jackfruit
Also Known As: Artocarpus heterophyllus, Arbol Del Pan, Baramil, Bo Luo Mi, Cakki, Chakka, Derakhte Nan, Falso Albero Del Pane, Fenesi, Finesy, Fruta Del Pobre, Halasina Hannu, Halasu, Indischer Brotfruchtbaum, Jaca, Jack, Jackfrucht, Jackfrugttrae, Jackfrukt, Jacktrad, Jacquier, Jak, Jaka, J
Drug: Dapagliflozin Propanediol, Metformin
Brand names:
Xigduo XR
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Dapagliflozin Propanediol, Metformin is classified as belonging to the following category: Antidiabetes Drugs
Theoretically, jackfruit might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies show that jackfruit flour and leaf extract can reduce fasting and postprandial blood glucose. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Fernando MR, Wickramasinghe N, Thabrew MI, Ariyananda PL, Karunanayake EH. Effect of Artocarpus heterophyllus and Asteracanthus longifolia on glucose tolerance in normal human subjects and in maturity-onset diabetic patients. J Ethnopharmacol 1991;31(3):2
- Rao AG, Naik KS, Unnikrishnan AG, Joseph J. Efficacy of green jackfruit flour as a medical nutrition therapy replacing rice or wheat in patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study. Nutr Diabetes 2021;11(1):
Jackfruit Overview
Jackfruit is a tropical fruit native to India and other parts of South and Southeast Asia. It is the largest tree-borne fruit in the world. It has a thick, spiky outer skin and a yellow, juicy flesh that is both sweet and slightly musky in flavor.
Jackfruit is a rich source of nutrients, including vitamins C and B6, potassium, and dietary fiber. It is also a good source of antioxidants. Jackfruit leaves, roots, bark, and latex have all been used for medicinal purposes.
Jackfruit - More Interactions
Jackfruit interacts with 433 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
Return to the main supplement interaction checker page
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
Ask A Pharmacist About Your Herbal Questions!
Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
Ask A Pharmacist