Drug & supplement interaction

Jackfruit + Ivosidenib

Ivosidenib brand name: Tibsovo.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Jackfruit and Ivosidenib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Jackfruit and Ivosidenib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ivosidenib and Jackfruit in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Jackfruit safety at a glance

Jackfruit overall Generally safe The ripe fruit is widely eaten and generally safe as a food for most people.
Pregnancy Use caution The fruit as food is likely fine, but concentrated supplements lack safety data and should be avoided unless approved by your doctor.
Breastfeeding Use caution Eating the fruit is likely fine, but there is not enough safety data on medicinal jackfruit products while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ivosidenib and Jackfruit? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ivosidenib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ivosidenib is filed under 5 classifications — including cytochrome p450 2c9 (cyp2c9) inducers, cytochrome p450 3a4 (cyp3a4) inducers, qt interval-prolonging drugs. Jackfruit has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and cns depressants (moderate) — and none of Ivosidenib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Jackfruit Does Interact With Other Medications

Jackfruit has 437 moderate known drug interactions in our database — Ivosidenib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 437 No known interaction 2,393 (incl. Ivosidenib)
Taking anything else?

Check Another of Your Medications Against Jackfruit

Covers the 2,830 medications we’ve checked against Jackfruit. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Jackfruit and Ivosidenib May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 3 of them are worth acting on rather than waiting out — marked below.

  • Shortness of breath / Hives / An allergic reaction Worth acting on Additional detail

    Jackfruit

    “Orally, the fruit of jackfruit might cause serious allergic reactions, including anaphylaxis, in sensitive individuals. In one case report, a 34-year-old female developed anaphylaxis with symptoms of cough, dyspnea, facial swelling, and urticaria after eating 10 pieces of dried jackfruit. There is speculation that latex allergy might result in a cross-reactivity to jackfruit.”

    Jackfruit · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    2 sources cited
    1. 98378. Wongrakpanich S, Klaewsongkram J, Chantaphakul H, Ruxrungtham K. Jackfruit anaphylaxis in a latex allergic patient. Asian Pac J Allergy Immunol. 2015;33(1):65-8.
    2. 112050. Jalil M, Hostoffer R, Wu SS. Jackfruit Anaphylaxis in a Latex Allergic Non-Healthcare Worker. Allergy Rhinol (Providence) 2021;12:21526567211009195. PubMed

    Ivosidenib

    Listed in the ADVERSE REACTIONS section of the FDA label for Ivosidenib. Read the label on DailyMed ›

  • Cough / Swelling Additional detail

    Jackfruit

    Recorded for Jackfruit in the same Natural Medicines adverse-effect record shown under Shortness of breath / Hives / An allergic reaction above.

    Ivosidenib

    Listed in the ADVERSE REACTIONS section of the FDA label for Ivosidenib. Read the label on DailyMed ›

Reported for Jackfruit but not commonly for Ivosidenib: a severe allergic reaction.

Effects for Ivosidenib come from the ADVERSE REACTIONS section of its FDA label; effects for Jackfruit come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Ivosidenib

This page covers Jackfruit only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ivosidenib page lists 162 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 115 moderate · 39 minor.

From our pharmacist’s overview on the Ivosidenib page

“Ivosidenib (Tibsovo) treats acute myeloid leukemia and bile duct cancer driven by an IDH1 mutation, and the 162 supplements on this list call for genuine vigilance, starting with the 8 rated major. Ivosidenib is cleared by the CYP3A4 enzyme, so grapefruit can drive its blood level up while St.”

Reviewed by 2 · Jul 18, 2026

Open the Ivosidenib interaction page

How much people look this up

Where Jackfruit and Ivosidenib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jackfruit
Top half

#619 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ivosidenib
Steady interest

#2,205 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jackfruit reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Jackfruit and Ivosidenib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Jackfruit

What is Jackfruit?

Jackfruit
  • General nutrition
  • Blood sugar support
  • Digestive health (fiber)
  • Antioxidant support
  • Wound care (traditional, latex/leaves)

Jackfruit is a large tropical fruit that is nutritious and safe to eat as a food, offering fiber, vitamin C, potassium, and antioxidants. While its leaves, seeds, and other parts are used in traditional medicine for things like blood sugar and digestion, strong human evidence for these supplement uses is limited. Talk to your pharmacist or doctor before using concentrated jackfruit products for a health condition.

Artocarpus heterophyllus · Moraceae · Fruit, seeds, leaves, bark, roots, and latex · Fresh or canned fruit, dried fruit, flour, seeds, capsules, powder, and leaf or bark extracts

An interaction check asks whether these two react with each other — it does not ask whether Jackfruit is a good idea for someone in your situation. Here is what our Jackfruit record says about it on its own.

Jackfruit: dosing

There is no established standard dose for jackfruit as a supplement. As a food, you can simply enjoy it as part of a balanced diet.For capsules, powders, or extracts, no proven medicinal dose has been set in research, so follow the directions on the product label.

From our Jackfruit monograph — the full record covers uses, side effects and every documented interaction.

Read the full Jackfruit monograph & all interactions
Medication

About Ivosidenib

What Is Ivosidenib Used For?

Brand name: Tibsovo

Tibsovo (ivosidenib) is used to treat adults who have a susceptible IDH1 mutation, confirmed by an FDA-approved test. It treats newly diagnosed acute myeloid leukemia (AML) in adults 75 or older, or those who cannot tolerate intensive chemotherapy — either alone or combined with a medicine called azacitidine. It also treats relapsed or refractory AML (AML that has come back or stopped responding to treatment) and relapsed or refractory myelodysplastic syndromes (MDS).

Tibsovo is also approved for adults with previously treated, locally advanced or metastatic cholangiocarcinoma (bile duct cancer that has spread) who carry an IDH1 mutation.

See full Ivosidenib drug information
Keep checking

Other Drugs & Jackfruit

Browse every other medication we’ve checked against Jackfruit — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
437Moderate
0Minor
2,392No known interaction
437 Moderate 2,392 No interaction
Moderate

437 interactions

Showing 60 of 437 moderate interactions — see all 437 on the Jackfruit page.

No interaction 2,392 drugs checked — show the list

We also checked Jackfruit against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,392 medications checked with no known interaction — see the full Jackfruit list.

See the full Jackfruit interactions page
See every supplement checked against Ivosidenib, ranked by severity
Evidence & sources

Jackfruit References

The 7 references that drive our Jackfruit monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Fernando MR, Wickramasinghe N, Thabrew MI, Ariyananda PL, Karunanayake EH. Effect of Artocarpus heterophyllus and Asteracanthus longifolia on glucose tolerance in normal human subjects and in maturity-onset diabetic patients. J Ethnopharmacol 1991;31(3):2 PubMed
  2. Ratnasooriya WD, Jayakody JR. Artocarpus heterophyllus seeds inhibits sexual competence but not fertility of male rats. Indian J Exp Biol 2002;40(3):304-308.
  3. Siritapetawee J, Thammasirirak S. Purification and characterization of a heteromultimeric glycoprotein from Artocarpus heterophylluslatex with an inhibitory effect on human blood coagulation. Acta Biochim Pol. 2011;58(4):521-8.
  4. Siritapetawee J, Thumanu K, Sojikul P, Thammasirirak S. A novel serine protease with human fibrino(geno)lytic activities from Artocarpus heterophylluslatex. Biochim Biophys Acta. 2012;1824(7):907-12.
  5. Wongrakpanich S, Klaewsongkram J, Chantaphakul H, Ruxrungtham K. Jackfruit anaphylaxis in a latex allergic patient. Asian Pac J Allergy Immunol. 2015;33(1):65-8.
  6. Jalil M, Hostoffer R, Wu SS. Jackfruit Anaphylaxis in a Latex Allergic Non-Healthcare Worker. Allergy Rhinol (Providence) 2021;12:21526567211009195. PubMed
  7. Rao AG, Naik KS, Unnikrishnan AG, Joseph J. Efficacy of green jackfruit flour as a medical nutrition therapy replacing rice or wheat in patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study. Nutr Diabetes 2021;11(1): PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Jackfruit and Ivosidenib Together: Common Questions

Is it safe to take Jackfruit with Ivosidenib?
We do not list a known interaction between Jackfruit and Ivosidenib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Jackfruit and Ivosidenib have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Jackfruit and Ivosidenib combination checked?
Interactions in our licensed database are recorded against drug classes. Ivosidenib is filed under 5 classifications, and Jackfruit has documented interactions with 3 drug classes — none of Ivosidenib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Jackfruit interact with any other medications?
Yes. Jackfruit has 437 documented drug interactions in our database — Ivosidenib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ivosidenib interact with any supplements?
Yes. Ivosidenib has documented interactions with 162 supplements in our database — Jackfruit is not one of them. The Ivosidenib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Jackfruit monograph Uses, safety profile, and every drug interaction in one place Ivosidenib drug information The full plain-English guide to this medication Ivosidenib supplement interactions Every supplement checked against Ivosidenib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ivosidenib and Jackfruit?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.