Glimepiride

250 interactions 384 cited references

Also sold as: Amaryl Amaryl®

About Glimepiride

Glimepiride is a diabetes medication that lowers blood sugar by helping the pancreas produce insulin and making the body use it better. Read the full Glimepiride drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abiraterone Acetate, Micronized Abiraterone Acetate Carbamazepine Apalutamide Ofloxacin Otic Moxifloxacin Ophthalmic

91 Major 156 Moderate 3 Minor

All (250) Major (91) Moderate (156) Minor (3)

Major

Glimepiride Azathioprine Azasan An increased risk of hepatotoxicity Details Glimepiride Abiraterone Abirtega An increased risk of severe hypoglycemia Details Glimepiride Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Glimepiride Chloroquine Aralen® Hypoglycemia Details Glimepiride Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Glimepiride Delafloxacin Injection Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Glimepiride Disopyramide Norpace Increased risk of hypoglycemia Details Glimepiride Dulaglutide Injection Trulicity Increased risk of hypoglycemia Details Glimepiride Entacapone Comtan Increased glimepiride exposure Details Glimepiride Fluorouracil Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Glimepiride Fluorouracil Injection Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Glimepiride Fluorouracil Topical Carac Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Glimepiride Furosemide Injection Disal An increased risk of hyperglycemia and an increased insulin requirement Details Glimepiride Gatifloxacin Ophthalmic Zymar® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Glimepiride Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Glimepiride Abiraterone Acetate Abirtega An increased risk of severe hypoglycemia Details Glimepiride Abiraterone Acetate, Micronized Abirtega An increased risk of severe hypoglycemia Details Glimepiride Apalutamide Erleada Reduced CYP2C9 substrates exposure Details Glimepiride Carbamazepine Carbatrol Reduced CYP2C9 substrate exposure and reduced efficacy of CYP2C9 substrate Details Glimepiride Chlorothiazide Diuril An increased risk of hyperglycemia and an increased insulin requirement Details Glimepiride Chlorthalidone Hemiclor An increased risk of hyperglycemia and an increased insulin requirement Details Glimepiride Ciprofloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Glimepiride Deutivacaftor Increased CYP2C9 substrate exposure Details Glimepiride Doxifluridine Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Glimepiride Dulaglutide Trulicity Increased risk of hypoglycemia Details Glimepiride Enoxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Glimepiride Fluconazole Diflucan Increased glimepiride exposure and an increased risk of glimepiride-related adverse events Details Glimepiride Furosemide Disal An increased risk of hyperglycemia and an increased insulin requirement Details Glimepiride Gatifloxacin Zymaxid Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Glimepiride Grepafloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Glimepiride Hydrochlorothiazide Inzirqo An increased risk of hyperglycemia and an increased insulin requirement Details Glimepiride Hydroflumethiazide An increased risk of hyperglycemia and an increased insulin requirement Details Glimepiride Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Glimepiride Indapamide An increased risk of hyperglycemia and an increased insulin requirement Details Glimepiride Insulin Afrezza An increased risk of hypoglycemia Details Glimepiride Insulin Aspart, Recombinant Fiasp An increased risk of hypoglycemia Details Glimepiride Insulin Bovine An increased risk of hypoglycemia Details Glimepiride Insulin Degludec Tresiba An increased risk of hypoglycemia Details Glimepiride Insulin Detemir Levemir An increased risk of hypoglycemia Details Glimepiride Insulin Glargine, Recombinant Basaglar An increased risk of hypoglycemia Details

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