Glimepiride and Clofibrate: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Glimepiride
Clofibrate
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased glimepiride exposure and increased blood glucose lowering effect and risk of hypoglycemia
Interaction Deep Dive
Concomitant use of glimepiride and gemfibrozil (an OATP1B1 transporter inhibitor) has resulted in an increase in the glimepiride exposure2. If concomitant use is required, monitor more closely for hypoglycemia. Monitor for worsening of glycemic control following discontinuation of a fibrate 1.
Why it happens (mechanism)
Unknown
Literature reports
1 report — tap to read
a) Concomitant use of glimepiride and gemfibrozil resulted in a 1.2-fold increase in the AUC of glimepiride related to gemfibrozil inhibition of the OATP1B1 transporter 2.
Common questions
Can I take Glimepiride and Clofibrate together?
Increased glimepiride exposure and increased blood glucose lowering effect and risk of hypoglycemia Always confirm with your pharmacist or prescriber before making any change.
How serious is the Glimepiride and Clofibrate interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Glimepiride or Clofibrate need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (2)
- Product Information: DUETACT oral tablets, pioglitazone glimepiride oral tablets. Takeda Pharmaceuticals America, Inc. (per FDA), Deerfield, IL, 2015. DailyMed
- Tornio A, Neuvonen PJ, Niemi M, et al: Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters. Expert Opin Drug Metab Toxicol 2017; 13(1):83-95. PubMed
Keep reading about Glimepiride
Keep reading about Clofibrate
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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