Clofibrate

15 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colchicine Simvastatin Atorvastatin Cyclosporine Injection Cyclosporine Ophthalmic Ezetimibe
8 Major 7 Moderate
All (15) Major (8) Moderate (7)

Major

Clofibrate Colchicine Colcrys Explained An increased risk of myopathy, including rhabdomyolysis Details Clofibrate Simvastatin Flolipid Explained An increased risk of myopathy or rhabdomyolysis Details Clofibrate Atorvastatin Atorvaliq An increased risk of myopathy and rhabdomyolysis Details Clofibrate Cyclosporine Injection Atopica Increased risk of renal dysfunction Details Clofibrate Cyclosporine Ophthalmic Cequa Increased risk of renal dysfunction Details Clofibrate Ezetimibe Zetia Increased ezetimibe exposure and an increased risk of cholelithiasis, myopathy and rhabdomyolysis Details Clofibrate Fluvastatin Lescol An increased risk of myopathy and rhabdomyolysis Details Clofibrate Lovastatin Altocor® An increased risk of myopathy or rhabdomyolysis Details

Moderate

Clofibrate Bempedoic Acid Nexletol An increased triglycerides and reduced high-density lipoprotein cholesterol (HDL-C) Details Clofibrate Furosemide Injection Disal Muscle pain and stiffness, accentuation of diuretic effects, and elevations in serum transaminases and creatine phosphokinase Details Clofibrate Glimepiride Amaryl Increased glimepiride exposure and increased blood glucose lowering effect and risk of hypoglycemia Details Clofibrate Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Clofibrate Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Clofibrate Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details Clofibrate Levothyroxine Ermeza Decreased levothyroxine exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.