Drug & supplement interaction

Tormentil + Glyburide

Glyburide brand names: Diabeta, Micronase, Glynase, Glycron, Micronized, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Tormentil and Glyburide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Tormentil and Glyburide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Glyburide and Tormentil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Tormentil at all — not against Glyburide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tormentil safety at a glance

Tormentil overall Use caution Generally considered low-risk for short-term use, but human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety has not been studied, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Glyburide and Tormentil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Tormentil and Glyburide May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Heartburn Additional detail

    Tormentil

    “Orally, tormentil has been reported to cause mild abdominal pain, heartburn, and feelings of fullness in one clinical trial. These adverse effects occurred at the same frequency for doses ranging from 1.2 grams daily to 3 grams daily.”

    Tormentil · Natural Medicines adverse-effect record, reported in dyspepsia.

    1 source cited
    1. 78590. Huber, R., Ditfurth, A. V., Amann, F., Guthlin, C., Rostock, M., Trittler, R., Kummerer, K., and Merfort, I. Tormentil for active ulcerative colitis: an open-label, dose-escalating study. J.Clin.Gastroenterol. 2007;41(9):834-838. PubMed

    Glyburide

    Listed in the ADVERSE REACTIONS section of the FDA label for Glyburide. Read the label on DailyMed ›

Reported for Tormentil but not commonly for Glyburide: stomach pain.

Effects for Glyburide come from the ADVERSE REACTIONS section of its FDA label; effects for Tormentil come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 24,289 voluntary FDA FAERS reports for Glyburide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Tormentil or Glyburide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Tormentil or Glyburide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Glyburide

This page covers Tormentil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glyburide page lists 331 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Beer (major), Grapefruit (major) and Siberian Cocklebur (major).

By severity: 7 major · 279 moderate · 45 minor.

Open the Glyburide interaction page

How much people look this up

Where Tormentil and Glyburide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tormentil
Steady interest

#825 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glyburide
Top half

#987 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tormentil reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Tormentil and Glyburide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tormentil

What is Tormentil?

  • Diarrhea
  • Mouth and throat inflammation
  • Mild digestive upset
  • Sore throat (gargle)
  • Minor wounds and skin irritation

Tormentil is a traditional herb whose root is rich in tannins and has long been used for diarrhea and as a mouth rinse for sore gums or throat. Some small studies suggest it may help shorten diarrhea, but overall evidence is limited and quality is low. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding because safety is not established.

Potentilla erecta · Rosaceae · Root and rhizome (underground stem) · Tincture, liquid extract, tea, capsules, mouth rinse

An interaction check asks whether these two react with each other — it does not ask whether Tormentil is a good idea for someone in your situation. Here is what our Tormentil record says about it on its own.

Tormentil: dosing

There is no official, standardized dose for tormentil, and products vary widely in strength. Tinctures, extracts, teas, and capsules will each have different recommended amounts.The safest approach is to follow the directions on the product label and not exceed them. If you are using it as a mouth rinse, do not swallow large amounts.

From our Tormentil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tormentil monograph & all interactions
Medication

About Glyburide

What Is Glyburide Used For?

Brand names: Diabeta, Micronase, Glynase, Glycron, Micronized, Glynase PresTab, Albert Glyburide

Glyburide tablets are used alongside diet and exercise to help control blood sugar in adults with type 2 diabetes. It is not for type 1 diabetes or diabetic ketoacidosis (a serious complication where the body produces dangerous levels of acids called ketones).

Glyburide may be used alone or combined with metformin when metformin alone is not enough. It can also be used to help transition patients who are moving from insulin or other diabetes pills to a new regimen, under a doctor's guidance.

Most-Reported Side Effects for Glyburide

From FAERS, the FDA’s public side-effect reporting system (24,289 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Blood glucose increased 3,062 reports
Nausea 2,050 reports
Weight decreased 1,547 reports
Diarrhea 1,319 reports
Dizziness 1,219 reports
See full Glyburide drug information
Keep checking

Other Drugs & Tormentil

Browse every other medication we’ve checked against Tormentil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Tormentil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Tormentil list.

See the full Tormentil interactions page
See every supplement checked against Glyburide, ranked by severity
Evidence & sources

Tormentil References

The 1 references that drive our Tormentil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Huber, R., Ditfurth, A. V., Amann, F., Guthlin, C., Rostock, M., Trittler, R., Kummerer, K., and Merfort, I. Tormentil for active ulcerative colitis: an open-label, dose-escalating study. J.Clin.Gastroenterol. 2007;41(9):834-838. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tormentil and Glyburide Together: Common Questions

Is it safe to take Tormentil with Glyburide?
We do not list a known interaction between Tormentil and Glyburide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tormentil and Glyburide have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Glyburide interact with any supplements?
Yes. Glyburide has documented interactions with 331 supplements in our database — Tormentil is not one of them. The Glyburide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tormentil monograph Uses, safety profile, and every drug interaction in one place Glyburide drug information The full plain-English guide to this medication Glyburide supplement interactions Every supplement checked against Glyburide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Glyburide and Tormentil?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.