Drug & supplement interaction

Ellagic Acid + Glyburide

Glyburide brand names: Diabeta, Micronase, Glynase, Glycron, Micronized, and others.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Ellagic Acid has a moderate interaction with Glyburide. Some clinical research shows that ellagic acid reduces fasting and postprandial glucose levels in patients with type 2 diabetes who are on stable doses of hypoglycemic agents such as metformin.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Ellagic Acid and Glyburide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Glyburide

Glyburide falls under ANTIDIABETES DRUGS — the group Ellagic Acid interacts with.

Some clinical research shows that ellagic acid reduces fasting and postprandial glucose levels in patients with type 2 diabetes who are on stable doses of hypoglycemic agents such as metformin. Theoretically, taking ellagic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to keep an eye on if you pair an ellagic acid supplement with glyburide. Some clinical research suggests ellagic acid can lower fasting and after-meal blood sugar in people with type 2 diabetes. Since glyburide already pushes your pancreas to release more insulin, stacking the two could nudge your blood sugar lower than you intend.

In plain terms, that means a slightly higher chance of low blood sugar (hypoglycemia): shakiness, sweating, dizziness, a racing heart, or feeling confused or hungry. This isn't a sure thing, just a possible additive effect, and eating berries or pomegranate in normal food amounts is unlikely to cause trouble. Concentrated supplements are the bigger question. Please don't change your glyburide on your own. Check with your pharmacist or doctor first, and keep monitoring your numbers.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Ghadimi M, Foroughi F, Hashemipour S, et al. Randomized double-blind clinical trial examining the Ellagic acid effects on glycemic status, insulin resistance, antioxidant, and inflammatory factors in patients with type 2 diabetes. Phytother Res 2021;35(2) PubMed
  2. Kazemi M, Lalooha F, Nooshabadi MR, Dashti F, Kavianpour M, Haghighian HK. Randomized double blind clinical trial evaluating the Ellagic acid effects on insulin resistance, oxidative stress and sex hormones levels in women with polycystic ovarian syndrome PubMed
  3. Ghadimi M, Foroughi F, Hashemipour S, et al. Decreased insulin resistance in diabetic patients by influencing Sirtuin1 and Fetuin-A following supplementation with ellagic acid: a randomized controlled trial. Diabetol Metab Syndr 2021;13(1):16. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Ellagic Acid Also Interacts With Other Medications

Ellagic Acid has 85 moderate known drug interactions in our database — the Glyburide one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. Glyburide)
Taking anything else?

Check Another of Your Medications Against Ellagic Acid

Covers the 2,830 medications we’ve checked against Ellagic Acid. Pick one to open its full report.

From our Q&A

Questions About Ellagic Acid or Glyburide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ellagic Acid or Glyburide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Glyburide

This page covers Ellagic Acid only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glyburide page lists 331 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Beer (major), Grapefruit (major) and Siberian Cocklebur (major).

By severity: 7 major · 279 moderate · 45 minor.

Open the Glyburide interaction page

One more smart check

Taking Ellagic Acid as Part of a Dietary Supplement Product? Check It for Interactions

We hold 121 real supplement products containing Ellagic Acid, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ellagic Acid. Your product may carry other ingredients that interact with Glyburide too, on top of Ellagic Acid — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ellagic Acid and Glyburide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ellagic Acid
Steady interest

#1,202 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glyburide
Top 25%

#705 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Ellagic Acid

What is Ellagic Acid?

  • Antioxidant support
  • General anti-aging or 'cleanse' products
  • Cancer prevention interest
  • Skin and beauty products
  • Heart and metabolic health

Ellagic acid is a natural plant compound (a polyphenol) found in foods like pomegranates, raspberries, strawberries, and walnuts. It is studied mostly in laboratory and animal research for antioxidant and possible anti-cancer effects, but strong human evidence is lacking. Eating ellagic-acid-rich foods is healthy, but supplements are not proven to treat any disease, so check with a pharmacist or doctor before using them.

Read the full Ellagic Acid monograph & all interactions
Medication

About Glyburide

What Is Glyburide Used For?

Brand names: Diabeta, Micronase, Glynase, Glycron, Micronized, Glynase PresTab, Albert Glyburide

Glyburide tablets are used alongside diet and exercise to help control blood sugar in adults with type 2 diabetes. It is not for type 1 diabetes or diabetic ketoacidosis (a serious complication where the body produces dangerous levels of acids called ketones).

Glyburide may be used alone or combined with metformin when metformin alone is not enough. It can also be used to help transition patients who are moving from insulin or other diabetes pills to a new regimen, under a doctor's guidance.

See full Glyburide drug information
Keep checking

Other Drugs & Ellagic Acid

Browse every other medication we’ve checked against Ellagic Acid — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Ellagic Acid page.

No interaction 2,744 drugs checked — show the list

We also checked Ellagic Acid against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Ellagic Acid list.

See the full Ellagic Acid interactions page
See every supplement checked against Glyburide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Ellagic Acid monograph › Uses, safety, and every drug interaction in one place Glyburide supplement interactions › Every supplement checked against Glyburide, ranked by severity Glyburide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Ellagic Acid and Glyburide Together: Common Questions

Can you take Ellagic Acid with Glyburide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Ellagic Acid and Glyburide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Glyburide and Ellagic Acid?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.