Drug & supplement interaction

Dimethylhexylamine (dmha) + Bosentan

Bosentan brand name: Tracleer.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Dimethylhexylamine (dmha) and Bosentan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Dimethylhexylamine (dmha) and Bosentan

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Bosentan and Dimethylhexylamine (dmha) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Dimethylhexylamine (dmha) safety at a glance

Dimethylhexylamine... overall Avoid DMHA is an unapproved stimulant with serious safety concerns and is best avoided.
Pregnancy Avoid Avoid during pregnancy; no safety data and it is a potent stimulant.
Breastfeeding Avoid Avoid while breastfeeding; no safety data and it may pass into breast milk.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Bosentan and Dimethylhexylamine (dmha)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Bosentan

Interactions in our licensed database are recorded against drug classes, not just single drug names. Bosentan is filed under 6 classifications — including organic anion-transporting polypeptide substrates (oatp), cytochrome p450 2c9 (cyp2c9) substrates, antihypertensive drugs. Dimethylhexylamine (dmha) has documented interactions with 1 drug class — the most serious being stimulant drugs (moderate) — and none of Bosentan’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Dimethylhexylamine (dmha) Does Interact With Other Medications

Dimethylhexylamine (dmha) has 172 moderate known drug interactions in our database — Bosentan isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Bosentan)
Taking anything else?

Check Another of Your Medications Against Dimethylhexylamine (dmha)

Covers the 2,830 medications we’ve checked against Dimethylhexylamine (dmha). Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Dimethylhexylamine (dmha) and Bosentan May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on reported in 4.6% of FDA reports for Bosentan Additional detail

    Dimethylhexylamine (dmha)

    “Theoretically, DMHA might be associated with an increased risk for hypertension, tachycardia, and cardiovascular events, as have been reported with a structurally similar stimulant, dimethylamylamine (DMAA).”

    Dimethylhexylamine (dmha) · Natural Medicines adverse-effect record, reported in hypertension.

    3 sources cited
    1. 17906. McCarthy C, Farney TM, Canale RE, et al. A finished dietary supplement stimulates lipolysis and metabolic rate in young men and women. Nutr Metab Insights 2012;5:23-31. PubMed
    2. 17907. McCarthy C, Canale RE, Alleman RJ, et al. Biochemical and anthropometric effects of a weight loss dietary supplement in health men and women. Nutr Metab Insights 2012;5:13-22.
    3. 17908. Farney TM, McCarthy C, Canale RE, et al. Hemodynamic and hematologic profile of health adults ingesting dietary supplements containing 1,3-dimethylamylamine and caffeine. Nutr Metab Insights 2012;5:1-12.

    Bosentan

    Listed in the ADVERSE REACTIONS section of the FDA label for Bosentan, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Dimethylhexylamine (dmha)

    Recorded for Dimethylhexylamine (dmha) in the same Natural Medicines adverse-effect record shown under Raised blood pressure above.

    Bosentan

    Listed in the ADVERSE REACTIONS section of the FDA label for Bosentan. Read the label on DailyMed ›

Effects for Bosentan come from the ADVERSE REACTIONS section of its FDA label; effects for Dimethylhexylamine (dmha) come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 50,110 voluntary FDA FAERS reports for Bosentan that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Bosentan

This page covers Dimethylhexylamine (dmha) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bosentan page lists 266 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Apple (major) and Beer (major).

By severity: 11 major · 216 moderate · 39 minor.

Open the Bosentan interaction page

One more smart check

Taking Dimethylhexylamine (dmha) as Part of a Dietary Supplement Product? Check It for Interactions

We hold 72 real supplement products containing Dimethylhexylamine (dmha), each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dimethylhexylamine (dmha). Even though Dimethylhexylamine (dmha) itself has no known interaction with Bosentan, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dimethylhexylamine (dmha) and Bosentan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dimethylhexylamine (dmha)
Top half

#473 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bosentan
Top half

#1,161 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dimethylhexylamine (dmha) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Dimethylhexylamine (dmha) and Bosentan records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Dimethylhexylamine (dmha)

What is Dimethylhexylamine (dmha)?

  • Pre-workout energy
  • Fat loss and weight management
  • Athletic performance
  • Appetite suppression
  • Focus and stimulation

DMHA (dimethylhexylamine, also called octodrine) is a synthetic stimulant added to some pre-workout and weight-loss supplements, often falsely labeled as a natural plant extract. It has not been shown to be safe as a dietary supplement, has been flagged by the FDA as an unapproved and potentially dangerous ingredient, and is best avoided. Talk to a pharmacist or doctor before using any product that contains it.

Synthetic chemical compound (not from a plant) · Capsules, tablets, powders, pre-workout blends

An interaction check asks whether these two react with each other — it does not ask whether Dimethylhexylamine (dmha) is a good idea for someone in your situation. Here is what our Dimethylhexylamine (dmha) record says about it on its own.

Dimethylhexylamine (dmha): dosing

There is no established safe or standardized dose for DMHA, and we do not recommend taking it. Do not try to guess a dose or combine it with other stimulants such as caffeine.

From our Dimethylhexylamine (dmha) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Dimethylhexylamine (dmha) monograph & all interactions
Medication

About Bosentan

What Is Bosentan Used For?

Brand name: Tracleer

Bosentan treats pulmonary arterial hypertension (PAH), which is high blood pressure in the arteries of the lungs (WHO Group 1). In adults, it helps improve exercise ability and slows clinical worsening.

In children 3 years and older with idiopathic or congenital PAH, it is used to improve pulmonary vascular resistance (the resistance blood meets in the lung vessels). This is expected to improve exercise ability. These uses appear on the Tracleer label and on the bosentan tablet and tablet for oral suspension labels.

Most-Reported Side Effects for Bosentan

From FAERS, the FDA’s public side-effect reporting system (50,110 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 6,001 reports
Pneumonia 2,698 reports
Pulmonary arterial hypertension 2,293 reports
Fatigue 2,258 reports
Headache 2,227 reports
See full Bosentan drug information
Keep checking

Other Drugs & Dimethylhexylamine (dmha)

Browse every other medication we’ve checked against Dimethylhexylamine (dmha) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
0Minor
2,657No known interaction
172 Moderate 2,657 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Dimethylhexylamine (dmha) page.

No interaction 2,657 drugs checked — show the list

We also checked Dimethylhexylamine (dmha) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Dimethylhexylamine (dmha) list.

See the full Dimethylhexylamine (dmha) interactions page
See every supplement checked against Bosentan, ranked by severity
Evidence & sources

Dimethylhexylamine (dmha) References

The 6 references that drive our Dimethylhexylamine (dmha) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McCarthy C, Farney TM, Canale RE, et al. A finished dietary supplement stimulates lipolysis and metabolic rate in young men and women. Nutr Metab Insights 2012;5:23-31. PubMed
  2. McCarthy C, Canale RE, Alleman RJ, et al. Biochemical and anthropometric effects of a weight loss dietary supplement in health men and women. Nutr Metab Insights 2012;5:13-22.
  3. Farney TM, McCarthy C, Canale RE, et al. Hemodynamic and hematologic profile of health adults ingesting dietary supplements containing 1,3-dimethylamylamine and caffeine. Nutr Metab Insights 2012;5:1-12.
  4. Rasmussen N, Keizers PH. History full circle: 'novel' sympathomimetics in supplements. Drug Test Anal 2016;8(3-4):283-6. PubMed
  5. Monroe RR, Drell HJ. Oral use of stimulants obtained from inhalers. J Am Med Assoc 1947; 135(14):909-15. PubMed
  6. Fellows EJ. The pharmacology of 2-amino-6-methylheptane. J Pharmacol Exp Ther 1947;90(4):351-8. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Dimethylhexylamine (dmha) and Bosentan Together: Common Questions

Is it safe to take Dimethylhexylamine (dmha) with Bosentan?
We do not list a known interaction between Dimethylhexylamine (dmha) and Bosentan. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Dimethylhexylamine (dmha) and Bosentan have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Dimethylhexylamine (dmha) and Bosentan combination checked?
Interactions in our licensed database are recorded against drug classes. Bosentan is filed under 6 classifications, and Dimethylhexylamine (dmha) has documented interactions with 1 drug class — none of Bosentan's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Dimethylhexylamine (dmha) interact with any other medications?
Yes. Dimethylhexylamine (dmha) has 172 documented drug interactions in our database — Bosentan is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Bosentan interact with any supplements?
Yes. Bosentan has documented interactions with 266 supplements in our database — Dimethylhexylamine (dmha) is not one of them. The Bosentan interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Dimethylhexylamine (dmha) monograph Uses, safety profile, and every drug interaction in one place Bosentan drug information The full plain-English guide to this medication Bosentan supplement interactions Every supplement checked against Bosentan, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Bosentan and Dimethylhexylamine (dmha)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.