Eurycoma Longifolia - Letairis (Ambrisentan) Interaction
Herbal: Eurycoma Longifolia
Also Known As: Akar Pasak Bumi, Ali's Umbrella, Ali's Walking Stick, Bedara Pahit, Canne d'Ali, Cay ba binh, Eurycoma, Eurycoma Longifolia Jack, Ian-don, Jelaih, Long Jack, Longjack, Malaysian Ginseng, Pasak Bumi, Payung Ali, Pokok Jelas, Pokok Syurga, Setunjang Bumi, Tho Nan, Tongkat Ali
Drug: Ambrisentan
Brand names:
Letairis, Volibris
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 18, 2025
Interaction Details
There were no interactions found between Ambrisentan and Eurycoma Longifolia. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Pharmacist Analysis
Although there is no known interaction in this case, Eurycoma longifolia, most commonly known as Tongkat Ali, does have some potential interactions that are important to be aware of.
For example, it may interact with the following:
- CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
- CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES
- CYTOCHROME P450 2A6 (CYP2A6) SUBSTRATES
- Propranolol
- Testosterone
Tongkat Ali has been reported to inhibit certain metabolizing enzymes in the liver (the ones mentioned above) and therefore, may increase the levels of substances metabolized by those enzymes. This could potentially affect the way these substances work or how long they stay in your system.
In regard to propranolol, some studies show that Tongkat Ali decreases how well propranolol is absorbed in the gut and could reduce its effects. It is not known if separating administration will prevent this interaction/
Lastly, testosterone, Tongkat Ali may theoretically further increase levels of testosterone, a hormone responsible for various functions in the body. You should be cautious combining the two.
- Dr. Brian Staiger, PharmDEurycoma Longifolia Overview
Eurycoma longifolia, also known as tongkat ali or "Malaysian ginseng," is a plant native to Southeast Asia. It is a member of the Simaroubaceae family and is known for its small, yellow flowers and elongated, slender leaves.
It has a long history of use in traditional medicine and is thought to have anti-inflammatory and pain-relieving effects.
Eurycoma longifolia is also purported to have a number of other medicinal properties, including the ability to improve immune function, reduce the risk of heart disease, and lower cholesterol levels.
Additionally, Eurycoma longifolia is commonly used as a natural treatment for male infertility and as a natural performance-enhancing supplement as it may have a mild androgenic effect. When used for male enhancement, it is most often marketed under other common names for the plant (e.g., tongkat ali, longjack).
Ambrisentan Overview
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Ambrisentan is used alone or in combination with tadalafil (Adcirca, Cialis) to treat pulmonary arterial hypertension (PAH, high blood pressure in the vessels that carry blood to the lungs). Ambrisentan may improve the ability to exercise and slow the worsening of symptoms in people with PAH. Ambrisentan is in a class of medications called endothelin receptor antagonists. It works by stopping the action of endothelin, a natural substance that causes blood vessels to narrow and prevents normal blood flow in people who have PAH.
Eurycoma Longifolia - More Interactions
Eurycoma Longifolia interacts with 247 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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