Drug & supplement interaction

Gamma-oryzanol + Ambrisentan

Ambrisentan brand names: Letairis, Volibris.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Gamma-oryzanol and Ambrisentan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Gamma-oryzanol and Ambrisentan

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ambrisentan and Gamma-oryzanol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Gamma-oryzanol at all — not against Ambrisentan, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Gamma-oryzanol safety at a glance

Gamma-oryzanol overall Use caution Generally well tolerated in studies, but long-term safety is not well established.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ambrisentan and Gamma-oryzanol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Ambrisentan’s Own FDA Label Lists

This is not an interaction — none of it involves Gamma-oryzanol. These are the most notable effects listed in the ADVERSE REACTIONS section of Ambrisentan’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

  • Heart failure Worth acting on
  • Anemia Worth acting on
  • Raised blood pressure Worth acting on
  • A severe allergic reaction Worth acting on
  • Liver problems Worth acting on
  • An allergic reaction Worth acting on
  • Flushing
  • A stuffy or runny nose
  • Cough
  • Low blood pressure

Showing the 10 most notable of 14 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Ambrisentan. Read the label on DailyMed › Gamma-oryzanol’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Gamma-oryzanol side to compare — that is a limit of the record, not a statement that Gamma-oryzanol has no side effects.

Overlapping uses

What Ambrisentan Is Prescribed For, and What Gamma-oryzanol Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Ambrisentan is a prescription medicine with approved uses on its FDA label. Gamma-oryzanol is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Ambrisentan is prescribed for: Ambrisentan tablets and Letairis tablets are both used to treat pulmonary arterial hypertension (PAH, WHO Group 1) — a condition where the blood pressure in the arteries leading to the lungs is dangerously high. Both are approved to help adults exercise better and slow the worsening of PAH. Both ambrisentan tablets and Letairis are also approved to be used together with tadalafil (another PAH medicine) to further reduce the risk of disease progression, lower the chance of hospitalization for worsening PAH, and improve exercise ability. Most of the clinical evidence was in patients with mild-to-moderate symptoms and PAH caused by unknown or inherited causes, or PAH linked to connective tissue diseases.

Gamma-oryzanol has been studied for:

  • Hypertension studied, not established Gamma-oryzanol has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Gamma-oryzanol for hypertension

    Oral gamma-oryzanol has only been evaluated in combination with sesame oil; its benefits when used alone are unclear.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Ambrisentan on your own; if you are taking Gamma-oryzanol for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Ambrisentan

This page covers Gamma-oryzanol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ambrisentan page lists 256 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Beer (major) and Grapefruit (major).

By severity: 9 major · 210 moderate · 37 minor.

Open the Ambrisentan interaction page

One more smart check

Taking Gamma-oryzanol as Part of a Dietary Supplement Product? Check It for Interactions

We hold 272 real supplement products containing Gamma-oryzanol, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Gamma-oryzanol. Even though Gamma-oryzanol itself has no known interaction with Ambrisentan, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Gamma-oryzanol and Ambrisentan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gamma-oryzanol
Top half

#663 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ambrisentan
Top half

#770 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Gamma-oryzanol and Ambrisentan records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Gamma-oryzanol

What is Gamma-oryzanol?

  • High cholesterol
  • Menopausal symptoms
  • Athletic performance and muscle building
  • Mild anxiety
  • Skin protection (topical)

Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The evidence is limited and mostly comes from small or older studies, so benefits are not well proven. It appears generally well tolerated, but talk with your pharmacist or doctor before using it.

Poaceae · Rice bran oil (derived from Oryza sativa bran) · Capsules, tablets, powder, topical creams

An interaction check asks whether these two react with each other — it does not ask whether Gamma-oryzanol is a good idea for someone in your situation. Here is what our Gamma-oryzanol record says about it on its own.

Gamma-oryzanol: dosing

There is no official or standardized dose for gamma-oryzanol. Doses used in research have varied widely, and what works for one use may not apply to another.The best approach is to follow the directions on the product label and not take more than recommended.

From our Gamma-oryzanol monograph — the full record covers uses, side effects and every documented interaction.

Read the full Gamma-oryzanol monograph & all interactions
Medication

About Ambrisentan

What Is Ambrisentan Used For?

Brand names: Letairis, Volibris

Ambrisentan tablets and Letairis tablets are both used to treat pulmonary arterial hypertension (PAH, WHO Group 1) — a condition where the blood pressure in the arteries leading to the lungs is dangerously high. Both are approved to help adults exercise better and slow the worsening of PAH.

Both ambrisentan tablets and Letairis are also approved to be used together with tadalafil (another PAH medicine) to further reduce the risk of disease progression, lower the chance of hospitalization for worsening PAH, and improve exercise ability. Most of the clinical evidence was in patients with mild-to-moderate symptoms and PAH caused by unknown or inherited causes, or PAH linked to connective tissue diseases.

See full Ambrisentan drug information
Keep checking

Other Drugs & Gamma-oryzanol

Browse every other medication we’ve checked against Gamma-oryzanol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Gamma-oryzanol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Gamma-oryzanol list.

See the full Gamma-oryzanol interactions page
See every supplement checked against Ambrisentan, ranked by severity
Sources

Sources & How We Checked

We checked Gamma-oryzanol against Ambrisentan in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Gamma-oryzanol monograph › Uses, safety, and every drug interaction in one place Ambrisentan supplement interactions › Every supplement checked against Ambrisentan, ranked by severity Ambrisentan drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Gamma-oryzanol and Ambrisentan Together: Common Questions

Is it safe to take Gamma-oryzanol with Ambrisentan?
We do not list a known interaction between Gamma-oryzanol and Ambrisentan. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Gamma-oryzanol and Ambrisentan used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Gamma-oryzanol in each. That is a conversation for your prescriber, especially if Ambrisentan is being adjusted to a target.
Does Ambrisentan interact with any supplements?
Yes. Ambrisentan has documented interactions with 256 supplements in our database — Gamma-oryzanol is not one of them. The Ambrisentan interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ambrisentan and Gamma-oryzanol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.